KEGG   DRUG: D08575Help
Entry
D08575                      Drug                                   

Name
Tetrabenazine (JAN/INN);
Nitoman (TN);
Xenazine (TN)
Product
Formula
C19H27NO3
Exact mass
317.1991
Mol weight
317.4226
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic [DS:H00059]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Indication: Huntington's disease
Target
Vesicular monoamine transporter 2 (VMAT2) inhibitor [HSA:6571] [KO:K08155]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07X OTHER NERVOUS SYSTEM DRUGS
    N07XX Other nervous system drugs
     N07XX06 Tetrabenazine
      D08575  Tetrabenazine (JAN/INN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Central Nervous System, Other
   Tetrabenazine
    D08575  Tetrabenazine (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D08575  Tetrabenazine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Major facilitator superfamily
   Vesicular monoamine transporter 2 (VMAT2)
    Tetrabenazine
     D08575  Tetrabenazine (INN)
BRITE hierarchy
Other DBs
CAS: 
58-46-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   C1x C    24.2200  -16.8700
            2   C1y C    24.2200  -18.2700
            3   N1y N    25.4100  -18.9700
            4   C1x C    26.6700  -18.2700
            5   C1y C    26.6700  -16.8700
            6   C5x C    25.4100  -16.1700
            7   C8y C    23.0300  -18.9700
            8   C8y C    23.0300  -20.3700
            9   C1x C    24.2200  -21.0700
            10  C1x C    25.4100  -20.3700
            11  C8y C    20.5800  -18.9700
            12  C8y C    20.5800  -20.3700
            13  C8x C    21.7700  -21.0700
            14  C8x C    21.7700  -18.2700
            15  O5x O    25.4100  -14.7700
            16  C1b C    27.8600  -16.1700
            17  C1c C    29.0500  -16.8700
            18  C1a C    30.2400  -16.1700
            19  C1a C    29.0500  -18.2700
            20  O2a O    19.3900  -18.2700
            21  O2a O    19.3900  -21.0700
            22  C1a C    18.1300  -18.9700
            23  C1a C    18.1300  -20.3700
BOND        25
            1     5   6 1
            2     6   1 1
            3    11  12 2
            4    12  13 1
            5    13   8 2
            6     7  14 2
            7    14  11 1
            8     1   2 1
            9     6  15 2
            10    2   3 1
            11    5  16 1
            12    3   4 1
            13   16  17 1
            14    7   8 1
            15   17  18 1
            16    8   9 1
            17   17  19 1
            18    9  10 1
            19   11  20 1
            20   10   3 1
            21   12  21 1
            22    2   7 1
            23   20  22 1
            24    4   5 1
            25   21  23 1

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