KEGG   DRUG: DexlansoprazoleHelp
Entry
D08903                      Drug                                   

Name
Dexlansoprazole (INN/USAN)
Product
Formula
C16H14F3N3O2S
Exact mass
369.0759
Mol weight
369.3615
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01646  Proton pump inhibitor (PPI)
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Unclassified
 DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Remark
ATC code: 
Activity
Anti-ulcerative, Proton pump inhibitor
Comment
Benzimidazole derivative
See [DR:D00355]
Non-erosive GERD, healing of erosive esophagitis, and maintenance of healing of erosive esophagitis
Target
ATP4A [HSA:495] [KO:K01542];
ATP4B [HSA:496] [KO:K01543]
  Pathway
Oxidative phosphorylation
Collecting duct acid secretion
Gastric acid secretion
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557], CYP1A2 [HSA:1544]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC06 Dexlansoprazole
      D08903  Dexlansoprazole (INN/USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Dexlansoprazole
     D08903  Dexlansoprazole (INN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
 CYP inducers
  CYP1A2
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
 CYP substrates
  CYP2C19
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
  CYP3A4
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
Gastrointestinal agents [br08371.html]
 Antiulcer agent
  D08903
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D08903
BRITE hierarchy
Other DBs
CAS: 
138530-94-6
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C     8.1200  -19.9500
            2   C8x C     8.1200  -21.3500
            3   C8x C     9.3324  -22.0500
            4   C8y C    10.5449  -21.3500
            5   C8y C    10.5449  -19.9500
            6   C8x C     9.3324  -19.2500
            7   N5x N    11.8764  -21.7826
            8   C8y C    12.6993  -20.6500
            9   N4x N    11.8764  -19.5174
            10  S4a S    14.0700  -20.6500
            11  C1b C    14.7700  -21.8624
            12  O3c O    14.7700  -19.4376
            13  C8y C    16.1698  -21.8624
            14  C8y C    16.8603  -23.0580
            15  C8y C    18.2603  -23.0578
            16  C8x C    18.9601  -21.8453
            17  C8x C    18.2697  -20.6498
            18  N5x N    16.8697  -20.6499
            19  C1a C    16.1749  -24.2452
            20  O2a O    18.9510  -24.2532
            21  C1b C    20.3696  -24.2532
            22  C1d C    21.0556  -25.4406
            23  X   F    21.7556  -26.6531
            24  X   F    22.2680  -24.7406
            25  X   F    19.8432  -26.1406
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1 #Down
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1

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