KEGG   DRUG: D08903Help
Entry
D08903                      Drug                                   

Name
Dexlansoprazole (INN/USAN)
Product
Formula
C16H14F3N3O2S
Exact mass
369.0759
Mol weight
369.3615
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Non-erosive GERD, healing of erosive esophagitis, and maintenance of healing of erosive esophagitis
Remark
ATC code: 
Comment
See [DR:D00355]
proton pump inhibitor
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
hsa00190  Oxidative phosphorylation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557], CYP1A2 [HSA:1544]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC06 Dexlansoprazole
      D08903  Dexlansoprazole (INN/USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Dexlansoprazole
     D08903  Dexlansoprazole (INN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
  CYP3A4
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
 Inhbitors
  CYP2C19
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
 Inducers
  CYP1A2
   Dexlansoprazole
    D08903  Dexlansoprazole (INN/USAN)
BRITE hierarchy
Other DBs
CAS: 
138530-94-6
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C     8.1200  -19.9500
            2   C8x C     8.1200  -21.3500
            3   C8x C     9.3324  -22.0500
            4   C8y C    10.5449  -21.3500
            5   C8y C    10.5449  -19.9500
            6   C8x C     9.3324  -19.2500
            7   N5x N    11.8764  -21.7826
            8   C8y C    12.6993  -20.6500
            9   N4x N    11.8764  -19.5174
            10  S4a S    14.0700  -20.6500
            11  C1b C    14.7700  -21.8624
            12  O3c O    14.7700  -19.4376
            13  C8y C    16.1698  -21.8624
            14  C8y C    16.8603  -23.0580
            15  C8y C    18.2603  -23.0578
            16  C8x C    18.9601  -21.8453
            17  C8x C    18.2697  -20.6498
            18  N5x N    16.8697  -20.6499
            19  C1a C    16.1749  -24.2452
            20  O2a O    18.9510  -24.2532
            21  C1b C    20.3696  -24.2532
            22  C1d C    21.0556  -25.4406
            23  X   F    21.7556  -26.6531
            24  X   F    22.2680  -24.7406
            25  X   F    19.8432  -26.1406
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1 #Down
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1

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