KEGG   DRUG: D08964Help
Entry
D08964                      Drug                                   

Name
Perampanel (USAN);
Fycompa (TN)
Product
Formula
C23H15N3O
Exact mass
349.1215
Mol weight
349.3847
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
AMPA-type glutamate receptor antagonist
Remark
ATC code: 
Target
AMPA receptor antagonist [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX22 Perampanel
      D08964  Perampanel (USAN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Glutamate Reducing Agents
   Perampanel
    D08964  Perampanel (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), non-NMDA
    AMPA receptor [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200]
     Perampanel [ATC:N03AX22]
      D08964  Perampanel (USAN)
BRITE hierarchy
Other DBs
CAS: 
380917-97-5
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        27
            1   C8x C    15.7500  -15.1200
            2   C8x C    15.7500  -16.5200
            3   C8y C    16.9624  -17.2200
            4   C8y C    18.1749  -16.5200
            5   C8x C    18.1749  -15.1200
            6   C8x C    16.9624  -14.4200
            7   C8y C    19.4060  -17.2310
            8   C8x C    19.4057  -18.6199
            9   C8y C    20.6180  -19.3202
            10  C8x C    21.8306  -18.6205
            11  N4y N    21.8309  -17.2316
            12  C8y C    20.6186  -16.5313
            13  C3b C    16.9624  -18.6198
            14  N3a N    16.9624  -20.0198
            15  C8y C    23.0553  -16.5251
            16  C8x C    24.2463  -17.2133
            17  C8x C    25.4590  -16.5137
            18  C8x C    25.4595  -15.1137
            19  C8x C    24.2686  -14.4255
            20  C8x C    23.0559  -15.1251
            21  C8y C    20.6177  -20.7196
            22  N5x N    19.4294  -21.4057
            23  C8x C    19.4294  -22.8057
            24  C8x C    20.6419  -23.5057
            25  C8x C    21.8301  -22.8196
            26  C8x C    21.8301  -21.4196
            27  O5x O    20.6187  -15.1204
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14    3  13 1
            15   13  14 3
            16   11  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   15  20 1
            23    9  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   12  27 2

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