KEGG   DRUG: Velaglucerase alfaHelp
Entry
D09029                      Drug                                   

Name
Velaglucerase alfa (USAN);
Velaglucerase alfa (genetical recombination) (JAN);
Vpriv (TN)
Product
Formula
C2532H3854N672O711S16
Exact mass
55562.1608
Mol weight
55596.809
Sequence
ARPCIPKSFG YSSVVCVCNA TYCDSFDPPT FPALGTFSRY ESTRSGRRME LSMGPIQANH
TGTGLLLTLQ PEQKFQKVKG FGGAMTDAAA LNILALSPPA QNLLLKSYFS EEGIGYNIIR
VPMASCDFSI RTYTYADTPD DFQLHNFSLP EEDTKLKIPL IHRALQLAQR PVSLLASPWT
SPTWLKTNGA VNGKGSLKGQ PGDIYHQTWA RYFVKFLDAY AEHKLQFWAV TAENEPSAGL
LSGYPFQCLG FTPEHQRDFI ARDLGPTLAN STHHNVRLLM LDDQRLLLPH WAKVVLTDPE
AAKYVHGIAV HWYLDFLAPA KATLGETHRL FPNTMLFASE ACVGSKFWEQ SVRLGSWDRG
MQYSHSIITN LLYHVVGWTD WNLALNPEGG PNWVRNFVDS PIIVDITKDT FYKQPMFYHL
GHFSKFIPEG SQRVGLVASQ KNDLDAVALM HPDGSAVVVV LNRSSKDVPL TIKDPAVGFL
ETISPGYSIH TYLWRRQ (Glycosylation site: 19; 59; 146; 270; 462)
  Type
Peptide
Remark
Therapeutic category: 
ATC code: 
Activity
Enzyme replenisher (glucocerebrosidase)
  Disease
Gaucher disease [DS:H00126]
Comment
human recombinant glucocerebrosidase [HSA:2629] [KO:K01201] [EC:3.2.1.45]
Treatment of patients with Gaucher disease
Interaction
Genomic biomarker: GBA [HSA:2629]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AB Enzymes
     A16AB10 Velaglucerase alfa
      D09029  Velaglucerase alfa (USAN)
USP drug classification [BR:br08302]
 Enzyme Replacement/Modifiers
  Velaglucerase alfa
   D09029  Velaglucerase alfa (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   395  Enzyme preparations
    3959  Others
     D09029  Velaglucerase alfa (USAN); Velaglucerase alfa (genetical recombination) (JAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09029
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09029
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09029
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09029
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D09029
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D09029
BRITE hierarchy
Other DBs
CAS: 
884604-91-5
PubChem: 
LinkDB All DBs

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