KEGG   DRUG: D09319Help
Entry
D09319                      Drug                                   

Name
Indacaterol maleate (JAN/USAN);
Arcapta neohaler (TN)
Product
Formula
C24H28N2O3. C4H4O4
Exact mass
508.221
Mol weight
508.5629
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of COPD (Chronic obstructive pulmonary disease)
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
long-acting beta-adrenoceptor agonist (LABA)
Target
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Genomic biomarker: UGT1A1 [HSA:54658]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AC Selective beta-2-adrenoreceptor agonists
     R03AC18 Indacaterol
      D09319  Indacaterol maleate (JAN/USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Indacaterol
    D09319  Indacaterol maleate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D09319  Indacaterol maleate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta2-adrenergic receptor
     Indacaterol
      D09319  Indacaterol maleate (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
753498-25-8
PubChem: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        37
            1   C1c C    17.0100  -21.4200
            2   C1b C    18.2700  -22.1200
            3   C8y C    15.8200  -22.1200
            4   N1b N    19.4600  -21.4900
            5   C1y C    20.6500  -22.1200
            6   C1x C    20.7900  -23.5200
            7   C8y C    22.1200  -23.8700
            8   C8y C    22.8900  -22.6100
            9   C1x C    21.9100  -21.5600
            10  C8x C    22.8200  -25.0600
            11  C8y C    24.2900  -25.0600
            12  C8y C    24.9900  -23.8700
            13  C8x C    24.2900  -22.6100
            14  C1b C    26.3900  -23.8700
            15  C1a C    27.0900  -25.0600
            16  C1b C    24.9200  -26.2500
            17  C1a C    26.3900  -26.2500
            18  C8y C    14.6300  -21.4900
            19  C8y C    13.3700  -22.1900
            20  C8y C    13.3700  -23.5900
            21  C8x C    14.6300  -24.2900
            22  C8x C    15.8200  -23.5900
            23  C8x C    14.6300  -20.0900
            24  C8x C    13.3700  -19.3900
            25  C8y C    12.1800  -20.0900
            26  N4x N    12.1800  -21.4900
            27  O5x O    10.9900  -19.3900
            28  O1a O    12.1800  -24.2900
            29  O1a O    17.0100  -20.0200
            30  C2b C    32.3400  -22.1900
            31  C2b C    34.0900  -22.1900
            32  C6a C    31.6400  -23.3800
            33  C6a C    34.7900  -23.3800
            34  O6a O    36.1900  -23.3800
            35  O6a O    30.2400  -23.3800
            36  O6a O    32.3400  -24.5700
            37  O6a O    34.0900  -24.5700
BOND        39
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   12  14 1
            16   14  15 1
            17   11  16 1
            18   16  17 1
            19    3  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24    3  22 1
            25   18  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 1
            29   19  26 1
            30   25  27 2
            31   20  28 1
            32    1  29 1 #Up
            33   30  31 2
            34   30  32 1
            35   31  33 1
            36   33  34 2
            37   32  35 1
            38   32  36 2
            39   33  37 1

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