KEGG   DRUG: D09329Help
Entry
D09329                      Drug                                   

Name
Conatumumab (USAN/INN)
Formula
C6466H10006N1730O2024S40
Exact mass
145554.2053
Mol weight
145643.6104
Sequence
(Heavy chain) QVQLQESGPG LVKPSQTLSL TCTVSGGSIS SGDYFWSWIR
QLPGKGLEWI GHIHNSGTTY YNPSLKSRVT ISVDTSKKQF SLRLSSVTAA DTAVYYCARD
RGGDYYYGMD VWGQGTTVTV SSASTKGPSV FPLAPSSKST SGGTAALGCL VDKYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT QTYICNVNHK PSNTKVDKRV
EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF
NWYVDGVEVH NAKTKPREEQ YNSTYRVVSVLTVLHQDWLN GKEYKCKVSN KALPAPIEKT
ISKAKGQPRE PQVYTLPPSR EEMTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP
PVLDSDGSFF LYSKLTVDLS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GK
(Dimer: H231-H'231; H234-H'234,  Disulfide brige: 22-97; 49-205; 266-326; 372-430, Glycosylation site: 302)
(Light chain) EIVLTQSPGT LSLSPGERAT LSCRASQGIS RSYLAWYQQK
PGQAPSLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE PEDFAVYYCQ QFGSSPWTFG
QGTKVEIKRT VAAPSVFIFP PSDEQLKSGT ASVVCLLNNF YPREAKVQWK VDNALQSGNS
QESVTEQDSK DSTYLSSTL TLSKADYEKH KVYACEVTHQ GLSSPVTKSF NRGEC
(Disulfide brige: 23-89; 135-195; H225-L215; H'225-L'215, Dimer)
  Type
Peptide
Activity
Treatment of cancer
Comment
agonistic monoclonal antibody
Target
CD262 (TRAIL-R2) agonist [HSA:8795] [KO:K04722]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04115  p53 signaling pathway
hsa04210  Apoptosis  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  TNF receptor family
   TNFRSF10B (CD262) [HSA:8795] [KO:K04722]
    Conatumumab
     D09329  Conatumumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
896731-82-1
PubChem: 
LinkDB All DBs

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