KEGG   DRUG: Gabapentin enacarbilHelp
Entry
D09539                      Drug                                   

Name
Gabapentin enacarbil (JAN/USAN/INN);
Horizant (TN)
Product
Formula
C16H27NO6
Exact mass
329.1838
Mol weight
329.3887
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG02037  GABA mimetic antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01574  Calcium channel alpha-2 delta blocker
Remark
Therapeutic category: 
Chemical group: 
Efficacy
Anticonvulsant
  Disease
Restless legs syndrome [DS:H01597]
Postherpetic neuralgia [DS:H01624]
Comment
Active form of prodrug: Gabapentin [DR:D00332]
Target
CACNA2D [HSA:781 9254 55799 93589] [KO:K04858 K04859 K04860 K04861];
SLC6A1 (GAT1) [HSA:6529] [KO:K05034]
  Pathway
MAPK signaling pathway
Metabolism
Enzyme: CES [HSA:1066 8824 23491 221223]
Interaction
Drug interaction
Structure map
Anticonvulsants
Brite
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Gabapentin
    D09539  Gabapentin enacarbil (JAN/USAN/INN)
 Central Nervous System Agents
  Central Nervous System, Other
   Gabapentin enacarbil
    D09539  Gabapentin enacarbil (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D09539  Gabapentin enacarbil (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    voltage-dependent calcium channel alpha-2
     Gabapentin
      D09539  Gabapentin enacarbil (JAN/USAN/INN)
 Transporters
  Solute carrier family
   SLC6
    SLC6A1 (GABA transporter 1)
     Gabapentin
      D09539  Gabapentin enacarbil (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D09539
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09539
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09539
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D09539
BRITE hierarchy
Other DBs
PubChem: 
ChEMBL: 
LigandBox: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   C1x C    17.3600  -19.4600
            2   C1x C    17.3600  -20.8600
            3   C1z C    18.5500  -21.5600
            4   C1x C    19.8100  -20.8600
            5   C1x C    19.8100  -19.4600
            6   C1x C    18.5500  -18.7600
            7   N1b N    16.1700  -21.5600
            8   C1b C    17.3600  -22.2600
            9   C1b C    19.7400  -22.2600
            10  C6a C    20.9300  -21.5600
            11  O6a O    20.9300  -20.1600
            12  O6a O    22.1453  -22.2551
            13  C7a C    14.9576  -22.2600
            14  O7a O    13.7451  -21.5600
            15  C1c C    12.5327  -22.2600
            16  O7a O    11.3203  -21.5600
            17  C7a C    10.1078  -22.2600
            18  C1c C     8.8954  -21.5600
            19  C1a C     7.6830  -22.2600
            20  O6a O    14.9576  -23.6598
            21  C1a C    12.5327  -23.6600
            22  O6a O    10.1078  -23.6597
            23  C1a C     8.8954  -20.1600
BOND        23
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   3 1
            9     3   9 1
            10    9  10 1
            11   10  11 2
            12   10  12 1
            13    7  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   13  20 2
            21   15  21 1
            22   17  22 2
            23   18  23 1

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