KEGG   DRUG: D09575Help
Entry
D09575                      Drug                                   

Name
Ibalizumab (USAN/INN)
Sequence
(Heavy chain) QVQLQQSGPE VVKPGASVKM SCKASGYTFT SYVIHWVRQK
PGQGLDWIGY INPYNDGTDY DEKFKGKATL TSDTSTSTAY MELSSLRSED TAVYYCAREK
DNYATGAWFA YWGQGTLVTV SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT
VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV VTVPSSSLGT KTYTCNVDHK PSNTKVDKRV
ESKYGPPCPS CPAPEFLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSQ EDPEVQFNWY
VDGVEVHNAK TKPREEQFNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKGL PSSIEKTISK
AKGQPREPQV YTLPPSQEEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL
DSDGSFFLYS RLTVDKSRWQ EGNVFSCSVM HEALHNHYTQ KSLSLSLGK (Dimer)
(Light chain) DIVMTQSPDS LAVSLGERVT MNCKSSQSLL YSTNQKNYLA
WYQQKPGQSP KLLIYWASTR ESGVPDRFSG SGSGTDFTLT ISSVQAEDVA VYYCQQYYSY
RTFGGGTKLE IKRTVAAPSV FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ
SGNSQESVTE QDSKDSTYSL SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Dimer)
  Type
Peptide
Activity
Treatment of HIV/AIDS in HIV-1 infected patients [DS:H00406]
Comment
Monoclonal antibody
Target
CD4 [HSA:920] [KO:K06454]
  Pathway
hsa04514  Cell adhesion molecules (CAMs)
hsa04660  T cell receptor signaling pathway  
 
Structure map
Anti-HIV agents
Brite
Target-based classification of drugs [BR:br08310]
 Others
  Cell adhesion molecules (CAMs)
   CD4
    Ibalizumab
     D09575  Ibalizumab (USAN/INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Entry / fusion inhibitor
    CD4 antibody
     Ibalizumab
      D09575  Ibalizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
680188-33-4
PubChem: 
LinkDB All DBs

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