KEGG   DRUG: D09874Help
Entry
D09874                      Drug                                   

Name
Benralizumab (USAN/INN)
Formula
C6492H10060N1724O2028S42
Exact mass
145964.5332
Mol weight
146054.4048
Sequence
(Heavy chain) EVQLVQSGAE VKKPGASVKV SCKASGYTFT SYVIHWVRQR
PGQGLAWMGY INPYNDGTKY NERFKGKVTI TSDRSTSTVY MELSSLRSED TAVYLCGREG
IRYYGLLGDY WGQGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV
SWNSGALTSG VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKKVE
PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN
WYVDGVEVHN  AKTKPREEQY  300 NSTYRVVSVL  TVLHQDWLNG  KEYKCKVSNK
ALPAPIEKTI  SKAKGQPREP  QVYTLPPSRD  ELTKNQVSLT  CLVKGFYPSD
IAVEWESNGQ  PENNYKTTPP  VLDSDGSFFL  YSKLTVDKSR  WQQGNVFSCS
VMHEALHNHY  TQKSLSLSPG  K
(Disulfide bridge: 22-96; 148-204; 265-325; 371-429, Dimer: 230; 233)
(Light chain) DIQMTQSPSS LSASVGDRVT ITCGTSEDII NYLNWYQQKP
GKAPKLLIYH TSRLQSGVPS RFSGSGSGTD FTLTISSLQP EDFATYYCQQ GYTLPYTFGQ
GTKVEIKRTV AAPSVFIFPP SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ
ESVTEQDSKD STYSLSSTLT LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: 23-88; 134-194; H224-L214, Dimer)
  Type
Peptide
Activity
Treatment of asthma
Comment
Monoclonal antibody
Target
CD125 (interleukin 5 receptor, alpha) [HSA:3568] [KO:K05067]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   interleukin 5 receptor, alpha [HSA:3568] [KO:K05067]
    Benralizumab
     D09874  Benralizumab (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
1044511-01-4
PubChem: 
LinkDB All DBs

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