KEGG   DRUG: Tofogliflozin
Entry
D09978                      Drug                                   
Name
Tofogliflozin (USAN);
Tofogliflozin hydrate (JAN);
Apleway (TN);
Deberza (TN)
Formula
C22H26O6. H2O
Exact mass
404.1835
Mol weight
404.4535
Structure
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01794  SGLT2 inhibitor
Metabolizing enzyme substrate
 DG02977  CYP2C18 substrate
 DG02978  CYP4A11 substrate
 DG02979  CYP4F3 substrate
Remark
Therapeutic category: 3969
Product: D09978<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Treatment of diabetes mellitus
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Metabolism
Enzyme: CYP2C18 [HSA:1562], CYP4A11 [HSA:1579], CYP4F3 [HSA:4051]
Interaction
Structure map
map07051  Antidiabetics
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D09978  Tofogliflozin (USAN); Tofogliflozin hydrate (JAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    D09978  Tofogliflozin
 Metabolizing enzyme substrate
  DG02977  CYP2C18 substrate
   D09978  Tofogliflozin
  DG02978  CYP4A11 substrate
   D09978  Tofogliflozin
  DG02979  CYP4F3 substrate
   D09978  Tofogliflozin
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01794  SGLT2 inhibitor
   D09978  Tofogliflozin
  DG02044  Hypoglycemic agent
   D09978  Tofogliflozin
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D09978  Tofogliflozin (USAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09978
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09978
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09978
Other DBs
CAS: 1201913-82-7
PubChem: 135626699
LigandBox: D09978
LinkDB
KCF data

ATOM        29
            1   O0  O    22.8312  -19.4121
            2   C1y C    12.7429  -15.8246
            3   C1y C    12.7429  -17.2251
            4   C1y C    13.9333  -17.9253
            5   C1z C    15.1936  -17.2251
            6   O2x O    15.1936  -15.8246
            7   C1y C    13.9333  -15.1244
            8   C1b C    13.9333  -13.7240
            9   O1a O    11.5525  -17.9253
            10  O1a O    11.5525  -15.1244
            11  O1a O    13.9333  -19.3257
            12  O1a O    15.1236  -13.0237
            13  O2x O    15.1936  -18.6255
            14  C1x C    16.5241  -19.0456
            15  C8y C    17.3643  -17.9253
            16  C8y C    16.5241  -16.8049
            17  C8x C    18.7648  -17.7852
            18  C8x C    19.3249  -16.4548
            19  C8y C    18.4847  -15.3345
            20  C8x C    17.0842  -15.5445
            21  C1b C    19.6751  -14.6342
            22  C8y C    20.8654  -15.3345
            23  C8x C    20.8654  -16.7349
            24  C8x C    22.1258  -17.4351
            25  C8y C    23.3162  -16.7349
            26  C8x C    23.3162  -15.3345
            27  C8x C    22.1258  -14.6342
            28  C1b C    24.5066  -17.4351
            29  C1a C    25.6969  -16.7349
BOND        31
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     2   7 1
            7     7   8 1 #Up
            8     3   9 1 #Up
            9     2  10 1 #Down
            10    4  11 1 #Down
            11    8  12 1
            12    5  13 1 #Down
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16    5  16 1 #Up
            17   15  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   16  20 1
            22   21  22 1
            23   21  19 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   22  27 1
            30   25  28 1
            31   28  29 1

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