KEGG   DRUG: D10094Help
Entry
D10094                      Drug                                   

Name
Blosozumab (USAN)
Formula
C6424H9852N1684O2030S46
Exact mass
144538.6608
Mol weight
144628.0165
Sequence
(Heavy chain)
QVQLVQSGAE VKKPGASVKV SCKVSGFPIK DTFQHWVRQA PGKGLEWMGW SDPEIGDTEY
ASKFQGRVTM TEDTSTDTAY MELSSLRSED TAVYYCATGD TTYKFDFWGQ GTTVTVSSAS
TKGPSVFPLA PCSRSTSEST AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTKTYT CNVDHKPSNT KVDKRVESKY GPPCPPCPAP EFLGGPSVFL
FPPKPKDTLM ISRTPEVTCV VVDVSQEDPE VQFNWYVDGV EVHNAKTKPR EEQFNSTYRV
VSVLTVLHQD WLNGKEYKCK VSNKGLPSSI EKTISKAKGQ PREPQVYTLP PSQEEMTKNQ
VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSRLTV DKSRWQEGNV
FSCSVMHEAL HNHYTQKSLS LSLG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCKASQDVH TAVAWYQQKP GKAPKLLIYW ASTRWTGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQQ YSDYPWTFGG GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge: H22-H96, H132-L214, H145-H201, H224-H'224, H227-H'227, H259-H319, H365-H423, H'22-H'96, H'132-L'214, H'145-H'201, H'259-H'319, H'365-H'423, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Activity
Treatment of osteoporosis
Comment
monoclonal antibody IgG4
Target
sclerostin (SOST) [HSA:50964] [KO:K16834]
  Pathway
hsa04310  Wnt signaling pathway  
 
Other DBs
CAS: 
1132758-87-2
PubChem: 
LinkDB All DBs

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