KEGG   DRUG: D10187Help
Entry
D10187                      Drug                                   

Name
Pateclizumab (USAN)
Formula
C6436H9910N1710O2004S44
Exact mass
144625.3826
Mol weight
144714.6652
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGYTFT SYVIHWVRQA PGKGLEWVGY NNPYNAGTNY
NEKFKGRFTI SSDKSKNTAY LQMNSLRAED TAVYYCSRPT MLPWFAYWGQ GTLVTVSSAS
TKGPSVFPLA PSSKSTSGGT AALGCLVKDY FPEPVTVSWN SGALTSGVHT FPAVLQSSGL
YSLSSVVTVP SSSLGTQTYI CNVNHKPSNT KVDKKVEPKS CDKTHTCPPC PAPELLGGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST
YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSREEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPG
(Light chain)
DIQMTQSPSS LSASVGDRVT ITCRASQAVS SAVAWYQQKP GKAPKLLIYS ASHRYTGVPS
RFSGSGSGTD FTLTISSLQP EDFATYYCQE SYSTPWTFGQ GTKVEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(dimer; disulfide bridge:H22-H96, H145-H201, H221-L214, H227-H'227, H230-H'230, H262-H322, H368-H426, H'22-H'96, H'145-H'201, H'221-L'214, H'262-H'322, H'368-H'426, L23-L88, L134-L194, L'23-L'88, L'134-L'194)
  Type
Peptide
Activity
Immune diseases and disorders
Comment
Monoclonal antibody
Target
lymphotoxin alpha (LTA) [HSA:4049] [KO:K05468]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   LTA [HSA:4049] [KO:K05468]
    Pateclizumab
     D10187  Pateclizumab (USAN)
BRITE hierarchy
Other DBs
CAS: 
1202526-59-7
PubChem: 
LinkDB All DBs

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