KEGG   DRUG: Tapentadol hydrochloride
Entry
D10199                      Drug                                   
Name
Tapentadol hydrochloride (JAN);
Nucynta (TN)
Product
NUCYNTA (Collegium Pharmaceutical), NUCYNTA (Collegium Pharmaceutical)
Formula
C14H23NO. HCl
Exact mass
257.1546
Mol weight
257.7995
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 8219
ATC code: N02AX06
Chemical structure group: DG00826
Product (DG00826): D10199<JP/US>
Efficacy
Analgesic, Opioid receptor agonist, Noradrenaline reuptake inhibitor
  Disease
Diabetic peripheral neuropathy (DPN) [DS:H01459]
Target
OPRM1 [HSA:4988] [KO:K04215]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04721  Synaptic vesicle cycle
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AX Other opioids
     N02AX06 Tapentadol
      D10199  Tapentadol hydrochloride (JAN) <JP/US>
USP drug classification [BR:br08302]
 Analgesics
  Opioid Analgesics, Long-acting
   Tapentadol
    D10199  Tapentadol hydrochloride (JAN)
  Opioid Analgesics, Short-acting
   Tapentadol
    D10199  Tapentadol hydrochloride (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
 8  Narcotics
  82  Non-alkaloidal narcotics
   821  Synthetic narcotics
    8219  Others
     D10199  Tapentadol hydrochloride (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00826  Tapentadol
     D10199  Tapentadol hydrochloride
 Analgesic
  DG01984  Opioid analgesics
   DG00826  Tapentadol
    D10199  Tapentadol hydrochloride
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00826  Tapentadol
    D10199  Tapentadol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D10199  Tapentadol hydrochloride (JAN) <JP/US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D10199  Tapentadol hydrochloride (JAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D10199
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10199
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10199
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10199
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00826  Tapentadol
 Analgesic
  DG01984  Opioid analgesics
   DG00826  Tapentadol
 Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00826  Tapentadol
Other DBs
CAS: 175591-09-0
PubChem: 163312232
LinkDB
KCF data

ATOM        17
            1   C8y C    17.4300  -17.0800
            2   C8x C    17.4300  -18.4800
            3   C8x C    18.6200  -19.1800
            4   C8x C    19.8800  -18.4800
            5   C8y C    19.8800  -17.0800
            6   C8x C    18.6200  -16.3800
            7   O1a O    16.1700  -16.3800
            8   C1c C    21.0700  -16.3800
            9   C1c C    22.2600  -17.0800
            10  C1b C    21.0700  -14.9800
            11  C1b C    23.4500  -16.3800
            12  C1a C    22.2600  -14.2800
            13  N1c N    24.6400  -17.0800
            14  C1a C    22.2600  -18.4800
            15  C1a C    25.9000  -16.3800
            16  C1a C    24.6400  -18.4800
            17  X   Cl   29.3300  -18.6200
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     5   8 1
            9     8   9 1
            10    8  10 1 #Down
            11    9  11 1
            12   10  12 1
            13   11  13 1
            14    9  14 1 #Down
            15   13  15 1
            16   13  16 1

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