KEGG   PATHWAY: bth00540Help
Entry
bth00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Bacteroides thetaiotaomicron VPI-5482
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
bth00540  Lipopolysaccharide biosynthesis
bth00540

Ortholog table
Module
bth_M00063  CMP-KDO biosynthesis [PATH:bth00540]
Other DBs
BSID: 12089
GO: 0009103
Organism
Bacteroides thetaiotaomicron VPI-5482 [GN:bth]
Gene
BT_3336  UDP-N-acetylglucosamine acyltransferase [KO:K00677] [EC:2.3.1.129]
BT_4205  UDP-N-acetylglucosamine acyltransferase [KO:K00677] [EC:2.3.1.129]
BT_4206  bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-ACP dehydratase [KO:K16363] [EC:4.2.1.59 3.5.1.108]
BT_4207  lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
BT_3697  UDP-2,3-diacylglucosamine hydrolase [KO:K03269] [EC:3.6.1.54]
BT_4004  lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
BT_1880  tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
BT_3306  sugar isomerase [KO:K06041] [EC:5.3.1.13]
BT_4321  2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
BT_1677  hydrolase [KO:K03270] [EC:3.1.3.45]
BT_0745  3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
BT_2747  3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
BT_2152  acetyltransferase [KO:K02517] [EC:2.3.1.241]
BT_0475  phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
BT_0477  phosphatase [KO:K03273] [EC:3.1.3.83 3.1.3.82]
BT_0474  D-glycero-D-manno-heptose 1-phosphate kinase [KO:K07031] [EC:2.7.1.168]
BT_0476  D-mannose-1-phosphate guanyltransferase [KO:K15669] [EC:2.7.7.71]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
ko00540   
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