KEGG   PATHWAY: hsa04010Help
Entry
hsa04010                    Pathway                                

Name
MAPK signaling pathway - Homo sapiens (human)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
MAPK signaling pathway
hsa04010

All organismsOrtholog table
Disease
H00078  
Frontotemporal lobar degeneration (FTLD)
H00265  
Hereditary sensory and autonomic neuropathy (HSAN)
H00484  
Other brachydactylies
H00523  
Noonan syndrome and related disorders
H00532  
RASA1-related disorders
H00539  
PTEN hamartoma tumor syndrome (PHTS)
H00540  
Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID)
H00574  
Coffin-Lowry syndrome (CLS)
H00577  
Syndromic X-linked mental retardation with epilepsy or seizures
H00595  
Myofibrillar myopathies (MFM)
H00642  
Lacrimo-auriculo-dento-digital syndrome (LADD)
H00645  
Incontinentia pigmenti
H00677  
Aplasia of lacrimal and salivary glands
H00728  
Brugada syndrome (BRS)
H00746  
Hypokalemic periodic paralysis (HypoPP)
H00749  
Episodic ataxias
H00775  
Familial or sporadic hemiplegic migraine
H00787  
Congenital stationary night blindness (CSNB)
H00800  
Loeys-Dietz syndrome (LDS)
H00801  
Familial thoracic aortic aneurysm and dissection (TAAD)
H00808  
Idiopathic generalized epilepsies (IGEs)
H00856  
Distal hereditary motor neuropathies (dHMN)
H00881  
Li-Fraumeni syndrome
H00882  
Cocoon syndrome
H00894  
FG syndrome (FGS)
H00912  
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
H00916  
Congenital central hypoventilation syndrome (CCHS)
H00997  
CATSHL syndrome
H01007  
Choroid plexus papilloma
H01193  
Familial tumoral calcinosis (FTC)
H01207  
Trigonocephaly
H01250  
Hereditary gingival fibromatosis (HGF)
H01276  
X-linked chronic idiopathic intestinal pseudo-obstruction
H01385  
Rienhoff syndrome
Drug
D00304  
Divalproex sodium (USP)
D00319  
Felodipine (JAN/USP/INN)
D00332  
Gabapentin (JAN/USAN/INN)
D00349  
Isradipine (USP/INN)
D00399  
Valproic acid (USP)
D00437  
Nifedipine (JP16/USP/INN)
D00438  
Nimodipine (USAN/INN)
D00538  
Zonisamide (JAN/USAN/INN)
D00539  
Ethosuximide (JP16/USP/INN)
D00615  
Amlodipine besilate (JP16)
D00616  
Diltiazem hydrochloride (JP16/USP)
D00617  
Nicardipine hydrochloride (JP16/USAN)
D00618  
Nisoldipine (JAN/USAN/INN)
D00619  
Verapamil hydrochloride (JP16/USP)
D00629  
Nitrendipine (JP16/USAN/INN)
D00631  
Bepridil hydrochloride hydrate (JAN)
D00710  
Sodium valproate (JP16)
D00742  
Etanercept (genetical recombination) (JAN)
D01104  
Barnidipine hydrochloride (JAN)
D01145  
Azelnidipine (JP16/INN)
D01173  
Cilnidipine (JAN/INN)
D01303  
Flunarizine hydrochloride (JAN/USAN)
D01441  
Imatinib mesilate (JAN)
D01553  
Manidipine hydrochloride (JP16)
D01562  
Aranidipine (JAN/INN)
D01604  
Efonidipine hydrochloride ethanolate (JAN)
D01908  
Nilvadipine (JP16/USAN/INN)
D01969  
Gallopamil hydrochloride (JAN)
D01977  
Gefitinib (JAN/USAN/INN)
D02045  
Benidipine hydrochloride (JP16)
D02356  
Verapamil (USAN/INN)
D02537  
Dronedarone (INN)
D02597  
Adalimumab (genetical recombination) (JAN)
D02598  
Infliximab (genetical recombination) (JAN)
D02630  
Penfluridol (USAN/INN)
D02716  
Pregabalin (JAN/USAN/INN)
D02914  
Amlodipine maleate (USAN)
D02934  
Anakinra (USAN/INN)
D03065  
Becaplermin (USAN/INN)
D03218  
Axitinib (JAN/USAN)
D03350  
Canertinib dihydrochloride (USAN)
D03441  
Certolizumab pegol (genetical recombination) (JAN)
D03455  
Cetuximab (genetical recombination) (JAN)
D03655  
Darodipine (USAN/INN)
D03658  
Dasatinib (INN)
D03736  
Doramapimod (USAN/INN)
D03830  
Diltiazem malate (USAN)
D03914  
Dronedarone hydrochloride (USAN)
D04023  
Erlotinib hydrochloride (JAN/USAN)
D04024  
Lapatinib tosilate hydrate (JAN)
D04358  
Golimumab (genetical recombination) (JAN)
D04657  
Lacidipine (USAN/INN)
D04696  
Lestaurtinib (USAN/INN)
D05024  
Mibefradil dihydrochloride (USAN)
D05029  
Midostaurin (USAN/INN)
D05146  
Nerelimomab (USAN/INN)
D05263  
Onercept (USAN/INN)
D05350  
Panitumumab (genetical recombination) (JAN)
D05380  
Pazopanib hydrochloride (JAN/USAN)
D05393  
Pegsunercept (USAN)
D05399  
Pelitinib (USAN/INN)
D06005  
Tandutinib (USAN/INN)
D06272  
Sorafenib tosilate (JAN)
D06285  
Vatalanib (USAN/INN)
D06402  
Sunitinib malate (JAN/USAN)
D06407  
Vandetanib (JAN/USAN/INN)
D06413  
Nilotinib hydrochloride hydrate (JAN)
D06414  
Dasatinib hydrate (JAN)
D06635  
Rilonacept (USAN/INN)
D06678  
Motesanib
D07185  
Fendiline (INN)
D07436  
Afelimomab (INN)
D07450  
Amlodipine (INN)
D07494  
Barnidipine (INN)
D07509  
Benidipine (INN)
D07520  
Bepridil (INN)
D07845  
Diltiazem (INN)
D07886  
Efonidipine (INN)
D07907  
Erlotinib (INN)
D07971  
Flunarizine (INN)
D08009  
Gallopamil (INN)
D08066  
Imatinib (INN)
D08108  
Lapatinib (INN)
D08155  
Manidipine (INN)
D08217  
Mibefradil (INN)
D08270  
Nicardipine (INN)
D08503  
Toceranib (USAN)
D08524  
Sorafenib (USAN/INN)
D08544  
Toceranib phosphate (USAN)
D08552  
Sunitinib (INN)
D08667  
Calcium valproate
D08878  
Brivanib alaninate (JAN/USAN/INN)
D08881  
Cediranib (USAN/INN)
D08883  
Cediranib maleate (JAN/USAN)
D08907  
Dovitinib lactate hydrate (JAN)
D08947  
Motesanib phosphate (JAN)
D08950  
Neratinib (INN/USAN)
D08953  
Nilotinib (USAN/INN)
D08963  
Pamapimod (INN/USAN)
D09315  
Canakinumab (genetical recombination) (JAN)
D09386  
Talmapimod (USAN/INN)
D09387  
Tanezumab (USAN/INN)
D09539  
Gabapentin enacarbil (JAN/USAN/INN)
D09589  
Brivanib (USAN)
D09602  
Dilmapimod (USAN/INN)
D09603  
Dilmapimod tosylate (USAN)
D09620  
Fresolimumab (USAN/INN)
D09635  
Linifanib (USAN/INN)
D09666  
Selumetinib (USAN/INN)
D09689  
Varlitinib (USAN/INN)
D09690  
Varlitinib tosylate (USAN)
D09724  
Afatinib (USAN/INN)
D09733  
Afatinib maleate (JAN)
D09907  
Fulranumab (USAN/INN)
D09911  
Gevokizumab (USAN/INN)
D09919  
Lenvatinib (USAN/INN)
D09920  
Lenvatinib mesilate (JAN)
D09939  
Olaratumab (USAN/INN)
D09944  
Ozoralizumab (USAN)
D10018  
Necitumumab (USAN/INN)
D10024  
Selumetinib sulfate (USAN)
D10031  
Zalutumumab (USAN/INN)
D10062  
Cabozantinib (USAN)
D10064  
Dabrafenib (USAN)
D10102  
Crenolanib (USAN)
D10103  
Crenolanib besylate (USAN)
D10104  
Dabrafenib mesylate (USAN)
D10137  
Regorafenib hydrate (JAN)
D10138  
Regorafenib (USAN/INN)
D10175  
Trametinib (USAN)
D10176  
Trametinib dimethyl sulfoxide (USAN)
D10405  
Cobimetinib (USAN/INN)
D10426  
Pimasertib (USAN/INN)
D10486  
Pimasertib hydrochloride (USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
773  
CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
774  
CACNA1B; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
775  
CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
776  
CACNA1D; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
777  
CACNA1E; calcium channel, voltage-dependent, R type, alpha 1E subunit [KO:K04852]
778  
CACNA1F; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
8913  
CACNA1G; calcium channel, voltage-dependent, T type, alpha 1G subunit [KO:K04854]
8912  
CACNA1H; calcium channel, voltage-dependent, T type, alpha 1H subunit [KO:K04855]
8911  
CACNA1I; calcium channel, voltage-dependent, T type, alpha 1I subunit [KO:K04856]
779  
CACNA1S; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
781  
CACNA2D1; calcium channel, voltage-dependent, alpha 2/delta subunit 1 [KO:K04858]
9254  
CACNA2D2; calcium channel, voltage-dependent, alpha 2/delta subunit 2 [KO:K04859]
55799  
CACNA2D3; calcium channel, voltage-dependent, alpha 2/delta subunit 3 [KO:K04860]
93589  
CACNA2D4; calcium channel, voltage-dependent, alpha 2/delta subunit 4 [KO:K04861]
782  
CACNB1; calcium channel, voltage-dependent, beta 1 subunit [KO:K04862]
783  
CACNB2; calcium channel, voltage-dependent, beta 2 subunit [KO:K04863]
784  
CACNB3; calcium channel, voltage-dependent, beta 3 subunit [KO:K04864]
785  
CACNB4; calcium channel, voltage-dependent, beta 4 subunit [KO:K04865]
786  
CACNG1; calcium channel, voltage-dependent, gamma subunit 1 [KO:K04866]
10369  
CACNG2; calcium channel, voltage-dependent, gamma subunit 2 [KO:K04867]
10368  
CACNG3; calcium channel, voltage-dependent, gamma subunit 3 [KO:K04868]
27092  
CACNG4; calcium channel, voltage-dependent, gamma subunit 4 [KO:K04869]
27091  
CACNG5; calcium channel, voltage-dependent, gamma subunit 5 [KO:K04870]
59285  
CACNG6; calcium channel, voltage-dependent, gamma subunit 6 [KO:K04871]
59284  
CACNG7; calcium channel, voltage-dependent, gamma subunit 7 [KO:K04872]
59283  
CACNG8; calcium channel, voltage-dependent, gamma subunit 8 [KO:K04873]
5566  
PRKACA; protein kinase, cAMP-dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
5567  
PRKACB; protein kinase, cAMP-dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
5568  
PRKACG; protein kinase, cAMP-dependent, catalytic, gamma [KO:K04345] [EC:2.7.11.11]
5613  
PRKX; protein kinase, X-linked [KO:K04345] [EC:2.7.11.11]
5578  
PRKCA; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
5579  
PRKCB; protein kinase C, beta [KO:K02677] [EC:2.7.11.13]
5582  
PRKCG; protein kinase C, gamma [KO:K02677] [EC:2.7.11.13]
2768  
GNA12; guanine nucleotide binding protein (G protein) alpha 12 [KO:K04346]
55970  
GNG12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
648044  
guanine nucleotide binding protein (G protein); K04347 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
5530  
PPP3CA; protein phosphatase 3, catalytic subunit, alpha isozyme [KO:K04348] [EC:3.1.3.16]
5532  
PPP3CB; protein phosphatase 3, catalytic subunit, beta isozyme [KO:K04348] [EC:3.1.3.16]
5533  
PPP3CC; protein phosphatase 3, catalytic subunit, gamma isozyme [KO:K04348] [EC:3.1.3.16]
5534  
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
5535  
PPP3R2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
5923  
RASGRF1; Ras protein-specific guanine nucleotide-releasing factor 1 [KO:K04349]
5924  
RASGRF2; Ras protein-specific guanine nucleotide-releasing factor 2 [KO:K12326]
10125  
RASGRP1; RAS guanyl releasing protein 1 (calcium and DAG-regulated) [KO:K04350]
10235  
RASGRP2; RAS guanyl releasing protein 2 (calcium and DAG-regulated) [KO:K12361]
25780  
RASGRP3; RAS guanyl releasing protein 3 (calcium and DAG-regulated) [KO:K12362]
115727  
RASGRP4; RAS guanyl releasing protein 4 [KO:K12363]
9693  
RAPGEF2; Rap guanine nucleotide exchange factor (GEF) 2 [KO:K08018]
4763  
NF1; neurofibromin 1 [KO:K08052]
5921  
RASA1; RAS p21 protein activator (GTPase activating protein) 1 [KO:K04352]
5922  
RASA2; RAS p21 protein activator 2 [KO:K08053]
5906  
RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
5908  
RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
4803  
NGF; nerve growth factor (beta polypeptide) [KO:K02582]
627  
BDNF; brain-derived neurotrophic factor [KO:K04355]
4908  
NTF3; neurotrophin 3 [KO:K04356]
4909  
NTF4; neurotrophin 4 [KO:K12457]
1950  
EGF; epidermal growth factor [KO:K04357]
2246  
FGF1; fibroblast growth factor 1 (acidic) [KO:K18496]
2247  
FGF2; fibroblast growth factor 2 (basic) [KO:K18497]
2248  
FGF3; fibroblast growth factor 3 [KO:K04358]
2249  
FGF4; fibroblast growth factor 4 [KO:K04358]
8822  
FGF17; fibroblast growth factor 17 [KO:K04358]
2251  
FGF6; fibroblast growth factor 6 [KO:K04358]
2252  
FGF7; fibroblast growth factor 7 [KO:K04358]
2253  
FGF8; fibroblast growth factor 8 (androgen-induced) [KO:K04358]
2254  
FGF9; fibroblast growth factor 9 [KO:K04358]
2255  
FGF10; fibroblast growth factor 10 [KO:K04358]
2256  
FGF11; fibroblast growth factor 11 [KO:K04358]
2257  
FGF12; fibroblast growth factor 12 [KO:K04358]
2258  
FGF13; fibroblast growth factor 13 [KO:K04358]
2259  
FGF14; fibroblast growth factor 14 [KO:K04358]
8823  
FGF16; fibroblast growth factor 16 [KO:K04358]
2250  
FGF5; fibroblast growth factor 5 [KO:K04358]
8817  
FGF18; fibroblast growth factor 18 [KO:K04358]
9965  
FGF19; fibroblast growth factor 19 [KO:K04358]
26281  
FGF20; fibroblast growth factor 20 [KO:K04358]
26291  
FGF21; fibroblast growth factor 21 [KO:K04358]
27006  
FGF22; fibroblast growth factor 22 [KO:K04358]
8074  
FGF23; fibroblast growth factor 23 [KO:K04358]
5154  
PDGFA; platelet-derived growth factor alpha polypeptide [KO:K04359]
5155  
PDGFB; platelet-derived growth factor beta polypeptide [KO:K17386]
4914  
NTRK1; neurotrophic tyrosine kinase, receptor, type 1 [KO:K03176] [EC:2.7.10.1]
4915  
NTRK2; neurotrophic tyrosine kinase, receptor, type 2 [KO:K04360] [EC:2.7.10.1]
1956  
EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
2260  
FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
2263  
FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
2261  
FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
2264  
FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
5156  
PDGFRA; platelet-derived growth factor receptor, alpha polypeptide [KO:K04363] [EC:2.7.10.1]
5159  
PDGFRB; platelet-derived growth factor receptor, beta polypeptide [KO:K05089] [EC:2.7.10.1]
2885  
GRB2; growth factor receptor-bound protein 2 [KO:K04364]
6654  
SOS1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
6655  
SOS2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
3265  
HRAS; Harvey rat sarcoma viral oncogene homolog [KO:K02833]
3845  
KRAS; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
4893  
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog [KO:K07828]
6237  
RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
22800  
RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
22808  
MRAS; muscle RAS oncogene homolog [KO:K07831]
673  
BRAF; v-raf murine sarcoma viral oncogene homolog B [KO:K04365] [EC:2.7.11.1]
5894  
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [KO:K04366] [EC:2.7.11.1]
4342  
MOS; v-mos Moloney murine sarcoma viral oncogene homolog [KO:K04367] [EC:2.7.11.1]
5604  
MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
5605  
MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
8649  
LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
5594  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  
MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
8569  
MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
2872  
MKNK2; MAP kinase interacting serine/threonine kinase 2 [KO:K04372] [EC:2.7.11.1]
6197  
RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3 [KO:K04373] [EC:2.7.11.1]
6195  
RPS6KA1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 [KO:K04373] [EC:2.7.11.1]
6196  
RPS6KA2; ribosomal protein S6 kinase, 90kDa, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
27330  
RPS6KA6; ribosomal protein S6 kinase, 90kDa, polypeptide 6 [KO:K04373] [EC:2.7.11.1]
468  
ATF4; activating transcription factor 4 [KO:K04374]
2002  
ELK1; ELK1, member of ETS oncogene family [KO:K04375]
2005  
ELK4; ELK4, ETS-domain protein (SRF accessory protein 1) [KO:K04376]
4609  
MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
6722  
SRF; serum response factor (c-fos serum response element-binding transcription factor) [KO:K04378]
2353  
FOS; FBJ murine osteosarcoma viral oncogene homolog [KO:K04379]
4137  
MAPT; microtubule-associated protein tau [KO:K04380]
3925  
STMN1; stathmin 1 [KO:K04381]
123745  
PLA2G4E; phospholipase A2, group IVE [KO:K16342] [EC:3.1.1.4]
5321  
PLA2G4A; phospholipase A2, group IVA (cytosolic, calcium-dependent) [KO:K16342] [EC:3.1.1.4]
8681  
JMJD7-PLA2G4B; JMJD7-PLA2G4B readthrough [KO:K16342] [EC:3.1.1.4]
PLA2G4B; phospholipase A2, group IVB (cytosolic) [KO:K16342] [EC:3.1.1.4]
8605  
PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent) [KO:K16342] [EC:3.1.1.4]
283748  
PLA2G4D; phospholipase A2, group IVD (cytosolic) [KO:K16342] [EC:3.1.1.4]
255189  
PLA2G4F; phospholipase A2, group IVF [KO:K16342] [EC:3.1.1.4]
7124  
TNF; tumor necrosis factor [KO:K03156]
3552  
IL1A; interleukin 1, alpha [KO:K04383]
3553  
IL1B; interleukin 1, beta [KO:K04519]
7040  
TGFB1; transforming growth factor, beta 1 [KO:K13375]
7042  
TGFB2; transforming growth factor, beta 2 [KO:K13376]
7043  
TGFB3; transforming growth factor, beta 3 [KO:K13377]
7132  
TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A [KO:K03158]
3554  
IL1R1; interleukin 1 receptor, type I [KO:K04386]
7850  
IL1R2; interleukin 1 receptor, type II [KO:K04387]
7046  
TGFBR1; transforming growth factor, beta receptor 1 [KO:K04674] [EC:2.7.11.30]
7048  
TGFBR2; transforming growth factor, beta receptor II (70/80kDa) [KO:K04388] [EC:2.7.11.30]
356  
FASLG; Fas ligand (TNF superfamily, member 6) [KO:K04389]
355  
FAS; Fas cell surface death receptor [KO:K04390]
929  
CD14; CD14 molecule [KO:K04391]
5879  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5881  
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
998  
CDC42; cell division cycle 42 [KO:K04393]
836  
CASP3; caspase 3, apoptosis-related cysteine peptidase [KO:K02187] [EC:3.4.22.56]
7186  
TRAF2; TNF receptor-associated factor 2 [KO:K03173]
1616  
DAXX; death-domain associated protein [KO:K02308]
7189  
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase [KO:K03175]
1647  
GADD45A; growth arrest and DNA-damage-inducible, alpha [KO:K04402]
4616  
GADD45B; growth arrest and DNA-damage-inducible, beta [KO:K04402]
10912  
GADD45G; growth arrest and DNA-damage-inducible, gamma [KO:K04402]
10454  
TAB1; TGF-beta activated kinase 1/MAP3K7 binding protein 1 [KO:K04403]
23118  
TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
51295  
ECSIT; ECSIT signalling integrator [KO:K04405]
8491  
MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
9448  
MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
11184  
MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
5058  
PAK1; p21 protein (Cdc42/Rac)-activated kinase 1 [KO:K04409] [EC:2.7.11.1]
5062  
PAK2; p21 protein (Cdc42/Rac)-activated kinase 2 [KO:K04410] [EC:2.7.11.1]
6789  
STK4; serine/threonine kinase 4 [KO:K04411]
6788  
STK3; serine/threonine kinase 3 [KO:K04412]
5871  
MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
1326  
MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
4214  
MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase [KO:K04416] [EC:2.7.11.25]
4296  
MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
10746  
MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
4215  
MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
9175  
MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
7786  
MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
51776  
ZAK; sterile alpha motif and leucine zipper containing kinase AZK [KO:K04424] [EC:2.7.11.25]
9064  
MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
4217  
MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
6885  
MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
4216  
MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
9344  
TAOK2; TAO kinase 2 [KO:K04429] [EC:2.7.11.1]
51347  
TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
57551  
TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
6416  
MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
5609  
MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
5606  
MAP2K3; mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
5608  
MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
9479  
MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
23542  
MAPK8IP2; mitogen-activated protein kinase 8 interacting protein 2 [KO:K04435]
23162  
MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
2316  
FLNA; filamin A, alpha [KO:K04437]
2318  
FLNC; filamin C, gamma [KO:K04437]
2317  
FLNB; filamin B, beta [KO:K04437]
1398  
CRK; v-crk avian sarcoma virus CT10 oncogene homolog [KO:K04438]
1399  
CRKL; v-crk avian sarcoma virus CT10 oncogene homolog-like [KO:K04438]
408  
ARRB1; arrestin, beta 1 [KO:K04439]
409  
ARRB2; arrestin, beta 2 [KO:K04439]
5599  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
5600  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
6300  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
5603  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
1432  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
8550  
MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
9261  
MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
7867  
MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
9252  
RPS6KA5; ribosomal protein S6 kinase, 90kDa, polypeptide 5 [KO:K04445] [EC:2.7.11.1]
8986  
RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4 [KO:K16510] [EC:2.7.11.1]
994  
CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
4772  
NFATC1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 [KO:K04446]
4775  
NFATC3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [KO:K17333]
3725  
JUN; jun proto-oncogene [KO:K04448]
3727  
JUND; jun D proto-oncogene [KO:K04449]
1386  
ATF2; activating transcription factor 2 [KO:K04450]
7157  
TP53; tumor protein p53 [KO:K04451]
1649  
DDIT3; DNA-damage-inducible transcript 3 [KO:K04452]
4149  
MAX; MYC associated factor X [KO:K04453]
4208  
MEF2C; myocyte enhancer factor 2C [KO:K04454]
3315  
HSPB1; heat shock 27kDa protein 1 [KO:K04455]
207  
AKT1; v-akt murine thymoma viral oncogene homolog 1 [KO:K04456] [EC:2.7.11.1]
208  
AKT2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
10000  
AKT3; v-akt murine thymoma viral oncogene homolog 3 [KO:K04456] [EC:2.7.11.1]
5494  
PPM1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A [KO:K04457] [EC:3.1.3.16]
5801  
PTPRR; protein tyrosine phosphatase, receptor type, R [KO:K04458] [EC:3.1.3.48]
84867  
PTPN5; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) [KO:K18018] [EC:3.1.3.48]
5778  
PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
1843  
DUSP1; dual specificity phosphatase 1 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1846  
DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1844  
DUSP2; dual specificity phosphatase 2 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1849  
DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1850  
DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1847  
DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1848  
DUSP6; dual specificity phosphatase 6 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1852  
DUSP9; dual specificity phosphatase 9 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
11221  
DUSP10; dual specificity phosphatase 10 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
80824  
DUSP16; dual specificity phosphatase 16 [KO:K04459] [EC:3.1.3.48 3.1.3.16]
1845  
DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.48 3.1.3.16]
5536  
PPP5C; protein phosphatase 5, catalytic subunit [KO:K04460] [EC:3.1.3.16]
PPP5D1; PPP5 tetratricopeptide repeat domain containing 1 [KO:K04460] [EC:3.1.3.16]
5495  
PPM1B; protein phosphatase, Mg2+/Mn2+ dependent, 1B [KO:K04461] [EC:3.1.3.16]
3312  
HSPA8; heat shock 70kDa protein 8 [KO:K03283]
3303  
HSPA1A; heat shock 70kDa protein 1A [KO:K03283]
3306  
HSPA2; heat shock 70kDa protein 2 [KO:K03283]
3305  
HSPA1L; heat shock 70kDa protein 1-like [KO:K03283]
3304  
HSPA1B; heat shock 70kDa protein 1B [KO:K03283]
3310  
HSPA6; heat shock 70kDa protein 6 (HSP70B') [KO:K03283]
2122  
MECOM; MDS1 and EVI1 complex locus [KO:K04462]
5607  
MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
5598  
MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
3164  
NR4A1; nuclear receptor subfamily 4, group A, member 1 [KO:K04465]
9020  
MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
1147  
CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
3551  
IKBKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [KO:K07209] [EC:2.7.11.10]
8517  
IKBKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma [KO:K07210]
51701  
NLK; nemo-like kinase [KO:K04468] [EC:2.7.11.24]
4790  
NFKB1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [KO:K02580]
4791  
NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [KO:K04469]
5970  
RELA; v-rel avian reticuloendotheliosis viral oncogene homolog A [KO:K04735]
5971  
RELB; v-rel avian reticuloendotheliosis viral oncogene homolog B [KO:K09253]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C00338  
Lipopolysaccharide
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
Reference
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
Reference
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
Reference
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
Reference
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
Reference
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
Reference
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
Reference
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
Reference
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
Reference
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
KO pathway
 
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