KEGG   PATHWAY: hsa04310Help
Entry
hsa04310                    Pathway                                

Name
Wnt signaling pathway - Homo sapiens (human)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Wnt signaling pathway
hsa04310

All organismsOrtholog table
Module
SCF-BTRC complex [PATH:hsa04310]
Wnt signaling [PATH:hsa04310]
Disease
H00078  
Frontotemporal lobar degeneration (FTLD)
H00409  
Type II diabetes mellitus
H00450  
Sclerosing bone dysplasias
H00451  
Osteoporosis-pseudoglioma syndrome (OPPG)
H00589  
Familial exudative vitreoretinopathy (FEVR)
H00598  
46,XX disorders of sex development (Disorders of gonadal development)
H00600  
46,XX disorders of sex development (Other)
H00607  
46,XY disorders of sex development (Disorders of gonadal development)
H00625  
Tooth agenesis
H00636  
Tetra-amelia
H00646  
Odontoonychodermal dysplasia
H00681  
Acne inversa
H00810  
Progressive myoclonic epilepsy (PME/ EPM)
H00857  
Oligodontia-colorectal cancer syndrome
H00881  
Li-Fraumeni syndrome
H00934  
Caudal duplication anomaly
H00947  
Pilomatricoma
H00949  
Focal dermal hypoplasia
H00979  
Caudal regression syndrome and Sirenomelia
H01007  
Choroid plexus papilloma
H01023  
Juvenile polyposis syndrome
H01025  
Familial adenomatous polyposis
H01037  
Vesicoureteral reflux
H01307  
Nonsyndromic congenital nail disorder (NDNC)
H01667  
Medulloblastoma
Drug
D10094  
Blosozumab (USAN)
D10156  
Romosozumab (USAN)
D10410  
Vantictumab (USAN)
Other DBs
BSID: 
GO: 
Organism
Homo sapiens (human) [GN:hsa]
Gene
64840  
K00181 O-palmitoleoyl transferase [EC:2.3.1.250] | (RefSeq) PORCN; porcupine homolog (Drosophila) [KO:K00181] [EC:2.3.1.250]
7471  
K03209 wingless-type MMTV integration site family; Wnt family member 1 [KO:K03209]
7472  
K00182 wingless-type MMTV integration site family; Wnt family member 2 [KO:K00182]
7482  
K00182 wingless-type MMTV integration site family; Wnt family member 2B [KO:K00182]
7473  
K00312 wingless-type MMTV integration site family; Wnt family member 3 [KO:K00312]
89780  
K00312 wingless-type MMTV integration site family; Wnt family member 3A [KO:K00312]
54361  
K00408 wingless-type MMTV integration site family; Wnt family member 4 [KO:K00408]
7474  
K00444 wingless-type MMTV integration site family; Wnt family member 5A [KO:K00444]
81029  
K00444 wingless-type MMTV integration site family; Wnt family member 5B [KO:K00444]
7475  
K00445 wingless-type MMTV integration site family; Wnt family member 6 [KO:K00445]
7476  
K00572 wingless-type MMTV integration site family; Wnt family member 7A [KO:K00572]
7477  
K00572 wingless-type MMTV integration site family; Wnt family member 7B [KO:K00572]
7478  
K00714 wingless-type MMTV integration site family; Wnt family member 8A [KO:K00714]
7479  
K00714 wingless-type MMTV integration site family; Wnt family member 8B [KO:K00714]
7483  
K01064 wingless-type MMTV integration site family; Wnt family member 9A [KO:K01064]
7484  
K01064 wingless-type MMTV integration site family; Wnt family member 9B [KO:K01064]
7480  
K01357 wingless-type MMTV integration site family; Wnt family member 10B [KO:K01357]
80326  
K01357 wingless-type MMTV integration site family; Wnt family member 10A [KO:K01357]
7481  
K01384 wingless-type MMTV integration site family; Wnt family member 11 [KO:K01384]
51384  
K01558 wingless-type MMTV integration site family; Wnt family member 16 [KO:K01558]
9350  
K01645 cerberus 1 | (RefSeq) CER1; cerberus 1, DAN family BMP antagonist [KO:K01645]
147111  
K19882 O-palmitoleoyl-L-serine hydrolase [EC:3.1.1.98] | (RefSeq) NOTUM; NOTUM, palmitoleoyl-protein carboxylesterase [KO:K19882] [EC:3.1.1.98]
11197  
K01691 WNT inhibitory factor 1 | (RefSeq) WIF1; WNT inhibitory factor 1 [KO:K01691]
5176  
K19614 pigment epithelium-derived factor | (RefSeq) SERPINF1; serpin family F member 1 [KO:K19614]
50964  
K16834 sclerostin | (RefSeq) SOST; sclerostin [KO:K16834]
22943  
K02165 dickkopf | (RefSeq) DKK1; dickkopf WNT signaling pathway inhibitor 1 [KO:K02165]
27123  
K02165 dickkopf | (RefSeq) DKK2; dickkopf WNT signaling pathway inhibitor 2 [KO:K02165]
27121  
K02165 dickkopf | (RefSeq) DKK4; dickkopf WNT signaling pathway inhibitor 4 [KO:K02165]
6422  
K02166 secreted frizzled-related protein 1 | (RefSeq) SFRP1; secreted frizzled related protein 1 [KO:K02166]
6423  
K02176 secreted frizzled-related protein 2 | (RefSeq) SFRP2; secreted frizzled related protein 2 [KO:K02176]
6424  
K02185 secreted frizzled-related protein 4 | (RefSeq) SFRP4; secreted frizzled related protein 4 [KO:K02185]
6425  
K02222 secreted frizzled-related protein 5 | (RefSeq) SFRP5; secreted frizzled related protein 5 [KO:K02222]
8321  
K02432 frizzled 1/7 | (RefSeq) FZD1; frizzled class receptor 1 [KO:K02432]
8324  
K02432 frizzled 1/7 | (RefSeq) FZD7; frizzled class receptor 7 [KO:K02432]
2535  
K02235 frizzled 2 | (RefSeq) FZD2; frizzled class receptor 2 [KO:K02235]
7976  
K02329 frizzled 3 | (RefSeq) FZD3; frizzled class receptor 3 [KO:K02329]
8322  
K02354 frizzled 4 | (RefSeq) FZD4; frizzled class receptor 4 [KO:K02354]
7855  
K02375 frizzled 5/8 | (RefSeq) FZD5; frizzled class receptor 5 [KO:K02375]
8325  
K02375 frizzled 5/8 | (RefSeq) FZD8; frizzled class receptor 8 [KO:K02375]
8323  
K02376 frizzled 6 | (RefSeq) FZD6; frizzled class receptor 6 [KO:K02376]
11211  
K02842 frizzled 9/10 | (RefSeq) FZD10; frizzled class receptor 10 [KO:K02842]
8326  
K02842 frizzled 9/10 | (RefSeq) FZD9; frizzled class receptor 9 [KO:K02842]
4041  
K03068 low density lipoprotein receptor-related protein 5/6 | (RefSeq) LRP5; LDL receptor related protein 5 [KO:K03068]
4040  
K03068 low density lipoprotein receptor-related protein 5/6 | (RefSeq) LRP6; LDL receptor related protein 6 [KO:K03068]
25805  
K10162 BMP and activin membrane-bound inhibitor | (RefSeq) BAMBI; BMP and activin membrane bound inhibitor [KO:K10162]
1454  
K08960 casein kinase 1; casein kinase 1 epsilon [KO:K08960] [EC:2.7.11.1]
K08960 casein kinase 1 [KO:K08960] [EC:2.7.11.1]
1857  
K02353 segment polarity protein dishevelled | (RefSeq) DVL3; dishevelled segment polarity protein 3 [KO:K02353]
1856  
K02353 segment polarity protein dishevelled | (RefSeq) DVL2; dishevelled segment polarity protein 2 [KO:K02353]
1855  
K02353 segment polarity protein dishevelled | (RefSeq) DVL1; dishevelled segment polarity protein 1 [KO:K02353]
10023  
K03069 frequently rearranged in advanced T-cell lymphomas 1 | (RefSeq) FRAT1; frequently rearranged in advanced T-cell lymphomas 1 [KO:K03069]
23401  
K03096 frequently rearranged in advanced T-cell lymphomas 2 | (RefSeq) FRAT2; frequently rearranged in advanced T-cell lymphomas 2 [KO:K03096]
1457  
K03097 casein kinase II subunit alpha [EC:2.7.11.1] | (RefSeq) CSNK2A1; casein kinase 2 alpha 1 [KO:K03097] [EC:2.7.11.1]
1459  
K03097 casein kinase II subunit alpha [EC:2.7.11.1] | (RefSeq) CSNK2A2; casein kinase 2 alpha 2 [KO:K03097] [EC:2.7.11.1]
283106  
K03097 casein kinase II subunit alpha [EC:2.7.11.1] | (RefSeq) CSNK2A3; casein kinase 2 alpha 3 [KO:K03097] [EC:2.7.11.1]
1460  
K03115 casein kinase II subunit beta | (RefSeq) CSNK2B; casein kinase 2 beta [KO:K03115]
85407  
K03213 naked cuticle | (RefSeq) NKD1; naked cuticle homolog 1 [KO:K03213]
85409  
K03213 naked cuticle | (RefSeq) NKD2; naked cuticle homolog 2 [KO:K03213]
80319  
K03344 Dvl-binding protein IDAX | (RefSeq) CXXC4; CXXC finger protein 4 [KO:K03344]
59343  
K03345 sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68] | (RefSeq) SENP2; SUMO1/sentrin/SMT3 specific peptidase 2 [KO:K03345] [EC:3.4.22.68]
2932  
K03083 glycogen synthase kinase 3 beta [EC:2.7.11.26] | (RefSeq) GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
1499  
K02105 catenin beta 1 | (RefSeq) CTNNB1; catenin beta 1 [KO:K02105]
8312  
K02157 axin 1 | (RefSeq) AXIN1; axin 1 [KO:K02157]
8313  
K04385 axin 2 | (RefSeq) AXIN2; axin 2 [KO:K04385]
324  
K02085 adenomatosis polyposis coli protein | (RefSeq) APC; APC, WNT signaling pathway regulator [KO:K02085]
10297  
K02085 adenomatosis polyposis coli protein | (RefSeq) APC2; APC2, WNT signaling pathway regulator [KO:K02085]
122011  
K08957 casein kinase 1; casein kinase 1 alpha 1 like [KO:K08957] [EC:2.7.11.1]
1452  
K08957 casein kinase 1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
6932  
K02620 transcription factor 7 | (RefSeq) TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
83439  
K04490 transcription factor 7-like 1 | (RefSeq) TCF7L1; transcription factor 7 like 1 [KO:K04490]
6934  
K04491 transcription factor 7-like 2 | (RefSeq) TCF7L2; transcription factor 7 like 2 [KO:K04491]
51176  
K04492 lymphoid enhancer-binding factor 1 | (RefSeq) LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
56998  
K04493 Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4) | (RefSeq) CTNNBIP1; catenin beta interacting protein 1 [KO:K04493]
57680  
K04494 chromodomain helicase DNA binding protein 8 [EC:3.6.4.12] | (RefSeq) CHD8; chromodomain helicase DNA binding protein 8 [KO:K04494] [EC:3.6.4.12]
64321  
K04495 transcription factor SOX17 (SOX group F) | (RefSeq) SOX17; SRY-box 17 [KO:K04495]
1487  
K04496 C-terminal binding protein | (RefSeq) CTBP1; C-terminal binding protein 1 [KO:K04496]
1488  
K04496 C-terminal binding protein | (RefSeq) CTBP2; C-terminal binding protein 2 [KO:K04496]
1387  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
2033  
K04498 E1A/CREB-binding protein [EC:2.3.1.48] | (RefSeq) EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
8607  
K04499 RuvB-like protein 1 (pontin 52) | (RefSeq) RUVBL1; RuvB like AAA ATPase 1 [KO:K04499]
4089  
K04501 mothers against decapentaplegic homolog 4 | (RefSeq) SMAD4; SMAD family member 4 [KO:K04501]
6885  
K04427 mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25] | (RefSeq) MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
51701  
K04468 nemo like kinase [EC:2.7.11.24] | (RefSeq) NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
4609  
K04377 Myc proto-oncogene protein | (RefSeq) MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
3725  
K04448 transcription factor AP-1 | (RefSeq) JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
8061  
K04502 fos-like antigen 1 | (RefSeq) FOSL1; FOS like 1, AP-1 transcription factor subunit [KO:K04502]
595  
K04503 cyclin D1 | (RefSeq) CCND1; cyclin D1 [KO:K04503]
894  
K10151 cyclin D2 | (RefSeq) CCND2; cyclin D2 [KO:K10151]
896  
K10152 cyclin D3 | (RefSeq) CCND3; cyclin D3 [KO:K10152]
5467  
K04504 peroxisome proliferator-activated receptor delta | (RefSeq) PPARD; peroxisome proliferator activated receptor delta [KO:K04504]
4316  
K01397 matrix metalloproteinase-7 (matrilysin; matrix metallopeptidase 7 [KO:K01397] [EC:3.4.24.23]
5663  
K04505 presenilin 1 [EC:3.4.23.-] | (RefSeq) PSEN1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
5566  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
5567  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
5568  
K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) PRKACG; protein kinase cAMP-activated catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
7157  
K04451 tumor protein p53 | (RefSeq) TP53; tumor protein p53 [KO:K04451]
6477  
K04506 E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27] | (RefSeq) SIAH1; siah E3 ubiquitin protein ligase 1 [KO:K04506] [EC:2.3.2.27]
27101  
K04507 calcyclin binding protein | (RefSeq) CACYBP; calcyclin binding protein [KO:K04507]
6500  
K03094 S-phase kinase-associated protein 1 | (RefSeq) SKP1; S-phase kinase-associated protein 1 [KO:K03094]
6907  
K04508 transducin (beta)-like 1 | (RefSeq) TBL1X; transducin beta like 1X-linked [KO:K04508]
90665  
K04508 transducin (beta)-like 1 | (RefSeq) TBL1Y; transducin beta like 1, Y-linked [KO:K04508]
79718  
K04508 transducin (beta)-like 1 | (RefSeq) TBL1XR1; transducin beta like 1 X-linked receptor 1 [KO:K04508]
8945  
K03362 F-box and WD-40 domain protein 1/11 | (RefSeq) BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase [KO:K03362]
23291  
K03362 F-box and WD-40 domain protein 1/11 | (RefSeq) FBXW11; F-box and WD repeat domain containing 11 [KO:K03362]
8454  
K03347 cullin 1 | (RefSeq) CUL1; cullin 1 [KO:K03347]
9978  
K03868 RING-box protein 1 | (RefSeq) RBX1; ring-box 1 [KO:K03868]
2239  
K08110 glypican 4 | (RefSeq) GPC4; glypican 4 [KO:K08110]
57216  
K04510 vang-like | (RefSeq) VANGL2; VANGL planar cell polarity protein 2 [KO:K04510]
81839  
K04510 vang-like | (RefSeq) VANGL1; VANGL planar cell polarity protein 1 [KO:K04510]
144165  
K04511 prickle | (RefSeq) PRICKLE1; prickle planar cell polarity protein 1 [KO:K04511]
166336  
K04511 prickle | (RefSeq) PRICKLE2; prickle planar cell polarity protein 2 [KO:K04511]
27130  
K19626 inversin | (RefSeq) INVS; inversin [KO:K19626]
23002  
K04512 dishevelled associated activator of morphogenesis | (RefSeq) DAAM1; dishevelled associated activator of morphogenesis 1 [KO:K04512]
23500  
K04512 dishevelled associated activator of morphogenesis | (RefSeq) DAAM2; dishevelled associated activator of morphogenesis 2 [KO:K04512]
387  
K04513 Ras homolog gene family; ras homolog family member A [KO:K04513]
9475  
K17388 Rho-associated protein kinase 2 [EC:2.7.11.1] | (RefSeq) ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
5879  
K04392 Ras-related C3 botulinum toxin substrate 1 | (RefSeq) RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
5880  
K07860 Ras-related C3 botulinum toxin substrate 2 | (RefSeq) RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
5881  
K07861 Ras-related C3 botulinum toxin substrate 3 | (RefSeq) RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
5599  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
5602  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
5601  
K04440 c-Jun N-terminal kinase [EC:2.7.11.24] | (RefSeq) MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
23236  
K05858 phosphatidylinositol phospholipase C; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
5330  
K05858 phosphatidylinositol phospholipase C; phospholipase C beta 2 [KO:K05858] [EC:3.1.4.11]
5331  
K05858 phosphatidylinositol phospholipase C; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
5332  
K05858 phosphatidylinositol phospholipase C; phospholipase C beta 4 [KO:K05858] [EC:3.1.4.11]
815  
K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | (RefSeq) CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
817  
K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | (RefSeq) CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
816  
K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | (RefSeq) CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
818  
K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17] | (RefSeq) CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
5530  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
5532  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
5533  
K04348 serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16] | (RefSeq) PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
5534  
K06268 serine/threonine-protein phosphatase 2B regulatory subunit | (RefSeq) PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
5535  
K06268 serine/threonine-protein phosphatase 2B regulatory subunit | (RefSeq) PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
5578  
K02677 classical protein kinase C alpha type [EC:2.7.11.13] | (RefSeq) PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
5579  
K19662 classical protein kinase C beta type [EC:2.7.11.13] | (RefSeq) PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
5582  
K19663 classical protein kinase C gamma type [EC:2.7.11.13] | (RefSeq) PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
4772  
K04446 nuclear factor of activated T-cells; nuclear factor of activated T-cells 1 [KO:K04446]
4773  
K17332 nuclear factor of activated T-cells; nuclear factor of activated T-cells 2 [KO:K17332]
4775  
K17333 nuclear factor of activated T-cells; nuclear factor of activated T-cells 3 [KO:K17333]
4776  
K17334 nuclear factor of activated T-cells; nuclear factor of activated T-cells 4 [KO:K17334]
4088  
K04500 mothers against decapentaplegic homolog 2/3 | (RefSeq) SMAD3; SMAD family member 3 [KO:K04500]
Compound
C00076  
Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates  Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
KO pathway
 
LinkDB All DBs

DBGET integrated database retrieval system