KEGG   Homo sapiens (human): 3815
Entry
3815              CDS       T01001                                 
Symbol
KIT, C-Kit, CD117, MASTC, PBT, SCFR
Name
(RefSeq) KIT proto-oncogene, receptor tyrosine kinase
  KO
K05091  proto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
hsa04916  Melanogenesis
hsa05200  Pathways in cancer
hsa05221  Acute myeloid leukemia
hsa05224  Breast cancer
hsa05230  Central carbon metabolism in cancer
Network
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06275  Acute myeloid leukemia
nt06526  MAPK signaling
nt06530  PI3K signaling
  Element
N00003  Mutation-activated KIT to RAS-ERK signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01599  Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL
N01656  GF-RTK-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
Disease
H00003  Acute myeloid leukemia
H00023  Testicular cancer
H00031  Breast cancer
H00170  Piebaldism
H01511  Mast-cell leukemia
H01591  Gastrotintestinal stromal tumor
Drug target
Amuvatinib (DG01916): D09864 D09865
Ancestim: D02937
Avapritinib: D11279<US>
Barzolvolimab: D12409
Bezuclastinib: D12600
Briquilimab: D12540
Catequentinib (DG03258): D12526 D12537
Dasatinib (DG00714): D03658<JP> D06414<JP/US> D12609
Dovitinib lactate: D08907
Elenestinib: D12450
Imatinib (DG00710): D01441<JP/US> D08066
Masitinib: D10229
Midostaurin: D05029<US>
Motesanib (DG01262): D06678 D08947
Nilotinib (DG00716): D06413<JP/US> D08953 D12444
Olverembatinib: D12175
Pazopanib: D05380<JP/US>
Pexidartinib (DG02960): D11270 D11271<US>
Regorafenib (DG00720): D10137<JP/US> D10138
Ripretinib: D11353<US>
Semaxanib: D05819
Sorafenib (DG00713): D06272<JP/US> D08524
Sunitinib (DG00712): D06402<JP/US> D08552
Tandutinib: D06005
Tivozanib (DG01375): D10190<US>
Toceranib (DG01363): D08503 D08544
Tuspetinib: D12476
Vatalanib: D06285
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    3815 (KIT)
   04014 Ras signaling pathway
    3815 (KIT)
   04015 Rap1 signaling pathway
    3815 (KIT)
   04072 Phospholipase D signaling pathway
    3815 (KIT)
   04151 PI3K-Akt signaling pathway
    3815 (KIT)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    3815 (KIT)
  09152 Endocrine system
   04916 Melanogenesis
    3815 (KIT)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    3815 (KIT)
   05230 Central carbon metabolism in cancer
    3815 (KIT)
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    3815 (KIT)
   05224 Breast cancer
    3815 (KIT)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    3815 (KIT)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    3815 (KIT)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     3815 (KIT)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  PDGFR family [OT]
   3815 (KIT)
CD molecules [BR:hsa04090]
 Proteins
  3815 (KIT)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Ig_3 ig I-set Ig_2 Ig_4 V-set Ig_6
Other DBs
NCBI-GeneID: 3815
NCBI-ProteinID: NP_000213
OMIM: 164920
HGNC: 6342
Ensembl: ENSG00000157404
UniProt: P10721
Structure
LinkDB
Position
4:54657957..54740715
AA seq 976 aa
MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
NT seq 2931 nt   +upstreamnt  +downstreamnt
atgagaggcgctcgcggcgcctgggattttctctgcgttctgctcctactgcttcgcgtc
cagacaggctcttctcaaccatctgtgagtccaggggaaccgtctccaccatccatccat
ccaggaaaatcagacttaatagtccgcgtgggcgacgagattaggctgttatgcactgat
ccgggctttgtcaaatggacttttgagatcctggatgaaacgaatgagaataagcagaat
gaatggatcacggaaaaggcagaagccaccaacaccggcaaatacacgtgcaccaacaaa
cacggcttaagcaattccatttatgtgtttgttagagatcctgccaagcttttccttgtt
gaccgctccttgtatgggaaagaagacaacgacacgctggtccgctgtcctctcacagac
ccagaagtgaccaattattccctcaaggggtgccaggggaagcctcttcccaaggacttg
aggtttattcctgaccccaaggcgggcatcatgatcaaaagtgtgaaacgcgcctaccat
cggctctgtctgcattgttctgtggaccaggagggcaagtcagtgctgtcggaaaaattc
atcctgaaagtgaggccagccttcaaagctgtgcctgttgtgtctgtgtccaaagcaagc
tatcttcttagggaaggggaagaattcacagtgacgtgcacaataaaagatgtgtctagt
tctgtgtactcaacgtggaaaagagaaaacagtcagactaaactacaggagaaatataat
agctggcatcacggtgacttcaattatgaacgtcaggcaacgttgactatcagttcagcg
agagttaatgattctggagtgttcatgtgttatgccaataatacttttggatcagcaaat
gtcacaacaaccttggaagtagtagataaaggattcattaatatcttccccatgataaac
actacagtatttgtaaacgatggagaaaatgtagatttgattgttgaatatgaagcattc
cccaaacctgaacaccagcagtggatctatatgaacagaaccttcactgataaatgggaa
gattatcccaagtctgagaatgaaagtaatatcagatacgtaagtgaacttcatctaacg
agattaaaaggcaccgaaggaggcacttacacattcctagtgtccaattctgacgtcaat
gctgccatagcatttaatgtttatgtgaatacaaaaccagaaatcctgacttacgacagg
ctcgtgaatggcatgctccaatgtgtggcagcaggattcccagagcccacaatagattgg
tatttttgtccaggaactgagcagagatgctctgcttctgtactgccagtggatgtgcag
acactaaactcatctgggccaccgtttggaaagctagtggttcagagttctatagattct
agtgcattcaagcacaatggcacggttgaatgtaaggcttacaacgatgtgggcaagact
tctgcctattttaactttgcatttaaaggtaacaacaaagagcaaatccatccccacacc
ctgttcactcctttgctgattggtttcgtaatcgtagctggcatgatgtgcattattgtg
atgattctgacctacaaatatttacagaaacccatgtatgaagtacagtggaaggttgtt
gaggagataaatggaaacaattatgtttacatagacccaacacaacttccttatgatcac
aaatgggagtttcccagaaacaggctgagttttgggaaaaccctgggtgctggagctttc
gggaaggttgttgaggcaactgcttatggcttaattaagtcagatgcggccatgactgtc
gctgtaaagatgctcaagccgagtgcccatttgacagaacgggaagccctcatgtctgaa
ctcaaagtcctgagttaccttggtaatcacatgaatattgtgaatctacttggagcctgc
accattggagggcccaccctggtcattacagaatattgttgctatggtgatcttttgaat
tttttgagaagaaaacgtgattcatttatttgttcaaagcaggaagatcatgcagaagct
gcactttataagaatcttctgcattcaaaggagtcttcctgcagcgatagtactaatgag
tacatggacatgaaacctggagtttcttatgttgtcccaaccaaggccgacaaaaggaga
tctgtgagaataggctcatacatagaaagagatgtgactcccgccatcatggaggatgac
gagttggccctagacttagaagacttgctgagcttttcttaccaggtggcaaagggcatg
gctttcctcgcctccaagaattgtattcacagagacttggcagccagaaatatcctcctt
actcatggtcggatcacaaagatttgtgattttggtctagccagagacatcaagaatgat
tctaattatgtggttaaaggaaacgctcgactacctgtgaagtggatggcacctgaaagc
attttcaactgtgtatacacgtttgaaagtgacgtctggtcctatgggatttttctttgg
gagctgttctctttaggaagcagcccctatcctggaatgccggtcgattctaagttctac
aagatgatcaaggaaggcttccggatgctcagccctgaacacgcacctgctgaaatgtat
gacataatgaagacttgctgggatgcagatcccctaaaaagaccaacattcaagcaaatt
gttcagctaattgagaagcagatttcagagagcaccaatcatatttactccaacttagca
aactgcagccccaaccgacagaagcccgtggtagaccattctgtgcggatcaattctgtc
ggcagcaccgcttcctcctcccagcctctgcttgtgcacgacgatgtctga

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