KEGG   Homo sapiens (human): 5371Help
Entry
5371              CDS       T01001                                 

Gene name
PML, MYL, PP8675, RNF71, TRIM19
Definition
promyelocytic leukemia
Orthology
K10054  
probable transcription factor PML
Organism
hsa  Homo sapiens (human)
Pathway
Ubiquitin mediated proteolysis
Endocytosis
Influenza A
Herpes simplex infection
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Disease
H00003  
Acute myeloid leukemia (AML)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    5371 (PML)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    5371 (PML)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5371 (PML)
   05202 Transcriptional misregulation in cancers
    5371 (PML)
   05221 Acute myeloid leukemia
    5371 (PML)
  Infectious diseases
   05164 Influenza A
    5371 (PML)
   05168 Herpes simplex infection
    5371 (PML)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
15q22
AA seq 633 aa AA seqDB search
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNESGFSWGYPHPFLI
NT seq 1902 nt NT seq  +upstreamnt  +downstreamnt
atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag
cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc
cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc
caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc
ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac
acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg
cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc
tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag
cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc
acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc
agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc
agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg
gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag
atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc
gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct
gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat
gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc
tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc
caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag
gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag
aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag
gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg
gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa
ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc
cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg
ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc
cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc
aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc
agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt
gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt
gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa
agtgggttctcctggggctacccccacccctttctaatttag

KEGG   Homo sapiens (human): 5914Help
Entry
5914              CDS       T01001                                 

Gene name
RARA, NR1B1, RAR
Definition
retinoic acid receptor, alpha
Orthology
K08527  
retinoic acid receptor alpha
Organism
hsa  Homo sapiens (human)
Pathway
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Disease
H00003  
Acute myeloid leukemia (AML)
H00516  
Isolated orofacial clefts
Drug target
Retinol (vit A): 
Tazarotene: 
Etretinate: 
Acitretin: 
Tretinoin: 
Adapalene: 
Isotretinoin: 
Alitretinoin: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5914 (RARA)
   05202 Transcriptional misregulation in cancers
    5914 (RARA)
   05221 Acute myeloid leukemia
    5914 (RARA)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  Zinc finger
   Cys4 thyroid hormone-like
    5914 (RARA)
Nuclear receptors [BR:hsa03310]
 1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   5914 (RARA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
17q21
AA seq 462 aa AA seqDB search
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPAT
IETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNM
VYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTL
TPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTV
EFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALK
VYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGL
DTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
NT seq 1389 nt NT seq  +upstreamnt  +downstreamnt
atggccagcaacagcagctcctgcccgacacctgggggcgggcacctcaatgggtacccg
gtgcctccctacgccttcttcttcccccctatgctgggtggactctccccgccaggcgct
ctgaccactctccagcaccagcttccagttagtggatatagcacaccatccccagccacc
attgagacccagagcagcagttctgaagagatagtgcccagccctccctcgccaccccct
ctaccccgcatctacaagccttgctttgtctgtcaggacaagtcctcaggctaccactat
ggggtcagcgcctgtgagggctgcaagggcttcttccgccgcagcatccagaagaacatg
gtgtacacgtgtcaccgggacaagaactgcatcatcaacaaggtgacccggaaccgctgc
cagtactgccgactgcagaagtgctttgaagtgggcatgtccaaggagtctgtgagaaac
gaccgaaacaagaagaagaaggaggtgcccaagcccgagtgctctgagagctacacgctg
acgccggaggtgggggagctcattgagaaggtgcgcaaagcgcaccaggaaaccttccct
gccctctgccagctgggcaaatacactacgaacaacagctcagaacaacgtgtctctctg
gacattgacctctgggacaagttcagtgaactctccaccaagtgcatcattaagactgtg
gagttcgccaagcagctgcccggcttcaccaccctcaccatcgccgaccagatcaccctc
ctcaaggctgcctgcctggacatcctgatcctgcggatctgcacgcggtacacgcccgag
caggacaccatgaccttctcggacgggctgaccctgaaccggacccagatgcacaacgct
ggcttcggccccctcaccgacctggtctttgccttcgccaaccagctgctgcccctggag
atggatgatgcggagacggggctgctcagcgccatctgcctcatctgcggagaccgccag
gacctggagcagccggaccgggtggacatgctgcaggagccgctgctggaggcgctaaag
gtctacgtgcggaagcggaggcccagccgcccccacatgttccccaagatgctaatgaag
attactgacctgcgaagcatcagcgccaagggggctgagcgggtgatcacgctgaagatg
gagatcccgggctccatgccgcctctcatccaggaaatgttggagaactcagagggcctg
gacactctgagcggacagccggggggtggggggcgggacgggggtggcctggcccccccg
ccaggcagctgtagccccagcctcagccccagctccaacagaagcagcccggccacccac
tccccgtga

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