KEGG   Homo sapiens (human): 673Help
Entry
673               CDS       T01001                                 

Gene name
BRAF, B-RAF1, BRAF1, NS7, RAFB1
Definition
B-Raf proto-oncogene, serine/threonine kinase (EC:2.7.11.1)
Orthology
K04365  
B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
mTOR signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Natural killer cell mediated cytotoxicity
Long-term potentiation
Neurotrophin signaling pathway
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00032  
Thyroid cancer
H00038  
Malignant melanoma
H00523  
Noonan syndrome and related disorders
Drug target
Sorafenib: 
Vemurafenib: 
Dabrafenib: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    673 (BRAF)
   04010 MAPK signaling pathway
    673 (BRAF)
   04012 ErbB signaling pathway
    673 (BRAF)
   04068 FoxO signaling pathway
    673 (BRAF)
   04024 cAMP signaling pathway
    673 (BRAF)
   04150 mTOR signaling pathway
    673 (BRAF)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    673 (BRAF)
  Cellular commiunity
   04510 Focal adhesion
    673 (BRAF)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    673 (BRAF)
   04062 Chemokine signaling pathway
    673 (BRAF)
  Endocrine system
   04910 Insulin signaling pathway
    673 (BRAF)
   04914 Progesterone-mediated oocyte maturation
    673 (BRAF)
  Circulatory system
   04270 Vascular smooth muscle contraction
    673 (BRAF)
  Nervous system
   04726 Serotonergic synapse
    673 (BRAF)
   04720 Long-term potentiation
    673 (BRAF)
   04730 Long-term depression
    673 (BRAF)
   04722 Neurotrophin signaling pathway
    673 (BRAF)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    673 (BRAF)
   05205 Proteoglycans in cancer
    673 (BRAF)
   05210 Colorectal cancer
    673 (BRAF)
   05212 Pancreatic cancer
    673 (BRAF)
   05214 Glioma
    673 (BRAF)
   05216 Thyroid cancer
    673 (BRAF)
   05221 Acute myeloid leukemia
    673 (BRAF)
   05220 Chronic myeloid leukemia
    673 (BRAF)
   05218 Melanoma
    673 (BRAF)
   05211 Renal cell carcinoma
    673 (BRAF)
   05219 Bladder cancer
    673 (BRAF)
   05215 Prostate cancer
    673 (BRAF)
   05213 Endometrial cancer
    673 (BRAF)
   05223 Non-small cell lung cancer
    673 (BRAF)
  Substance dependence
   05034 Alcoholism
    673 (BRAF)
  Infectious diseases
   05160 Hepatitis C
    673 (BRAF)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     673 (BRAF)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   673 (BRAF)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
7q34
AA seq 766 aa AA seqDB search
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
NT seq 2301 nt NT seq  +upstreamnt  +downstreamnt
atggcggcgctgagcggtggcggtggtggcggcgcggagccgggccaggctctgttcaac
ggggacatggagcccgaggccggcgccggcgccggcgccgcggcctcttcggctgcggac
cctgccattccggaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacat
atagaggccctattggacaaatttggtggggagcataatccaccatcaatatatctggag
gcctatgaagaatacaccagcaagctagatgcactccaacaaagagaacaacagttattg
gaatctctggggaacggaactgatttttctgtttctagctctgcatcaatggataccgtt
acatcttcttcctcttctagcctttcagtgctaccttcatctctttcagtttttcaaaat
cccacagatgtggcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttc
ctgcccaacaaacagaggacagtggtacctgcaaggtgtggagttacagtccgagacagt
ctaaagaaagcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaatt
caggatggagagaagaaaccaattggttgggacactgatatttcctggcttactggagaa
gaattgcatgtggaagtgttggagaatgttccacttacaacacacaactttgtacgaaaa
acgtttttcaccttagcattttgtgacttttgtcgaaagctgcttttccagggtttccgc
tgtcaaacatgtggttataaatttcaccagcgttgtagtacagaagttccactgatgtgt
gttaattatgaccaacttgatttgctgtttgtctccaagttctttgaacaccacccaata
ccacaggaagaggcgtccttagcagagactgccctaacatctggatcatccccttccgca
cccgcctcggactctattgggccccaaattctcaccagtccgtctccttcaaaatccatt
ccaattccacagcccttccgaccagcagatgaagatcatcgaaatcaatttgggcaacga
gaccgatcctcatcagctcccaatgtgcatataaacacaatagaacctgtcaatattgat
gacttgattagagaccaaggatttcgtggtgatggaggatcaaccacaggtttgtctgct
accccccctgcctcattacctggctcactaactaacgtgaaagccttacagaaatctcca
ggacctcagcgagaaaggaagtcatcttcatcctcagaagacaggaatcgaatgaaaaca
cttggtagacgggactcgagtgatgattgggagattcctgatgggcagattacagtggga
caaagaattggatctggatcatttggaacagtctacaagggaaagtggcatggtgatgtg
gcagtgaaaatgttgaatgtgacagcacctacacctcagcagttacaagccttcaaaaat
gaagtaggagtactcaggaaaacacgacatgtgaatatcctactcttcatgggctattcc
acaaagccacaactggctattgttacccagtggtgtgagggctccagcttgtatcaccat
ctccatatcattgagaccaaatttgagatgatcaaacttatagatattgcacgacagact
gcacagggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaat
aatatatttcttcatgaagacctcacagtaaaaataggtgattttggtctagctacagtg
aaatctcgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatg
gcaccagaagtcatcagaatgcaagataaaaatccatacagctttcagtcagatgtatat
gcatttggaattgttctgtatgaattgatgactggacagttaccttattcaaacatcaac
aacagggaccagataatttttatggtgggacgaggatacctgtctccagatctcagtaag
gtacggagtaactgtccaaaagccatgaagagattaatggcagagtgcctcaaaaagaaa
agagatgagagaccactctttccccaaattctcgcctctattgagctgctggcccgctca
ttgccaaaaattcaccgcagtgcatcagaaccctccttgaatcgggctggtttccaaaca
gaggattttagtctatatgcttgtgcttctccaaaaacacccatccaggcagggggatat
ggtgcgtttcctgtccactga

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