| Entry |
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| Gene name |
VKORC1, EDTP308, MST134, MST576, VKCFD2, VKOR
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| Definition |
(RefSeq) vitamin K epoxide reductase complex subunit 1
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| KO |
| vitamin-K-epoxide reductase (warfarin-sensitive) [EC: 1.17.4.4] |
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| Organism |
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| Pathway |
| Ubiquinone and other terpenoid-quinone biosynthesis |
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| Disease |
| Combined deficiency of vitamin K-dependent clotting factors (VKCFD) | | Coumarin resistance |
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| Drug target |
Acenocoumarol: Clorindione: Dicoumarol: Diphenadione: Ethyl biscoumacetate: Flocoumafen: Fluindione: Phenindion type coumarin derivative ( DG01761): Phenindione: Phenprocoumon: Tioclomarol: |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Metabolism
Metabolism of cofactors and vitamins
00130 Ubiquinone and other terpenoid-quinone biosynthesis
79001 (VKORC1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
1.17 Acting on CH or CH2 groups
1.17.4 With a disulfide as acceptor
1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
79001 (VKORC1)
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| SSDB |
   |
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| Motif |
 |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
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| LinkDB |
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| Position |
16p11.2
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| AA seq |
163 aa  
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH |
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| NT seq |
492 nt  +upstreamnt +downstreamnt
atgggcagcacctgggggagccctggctgggtgcggctcgctctttgcctgacgggctta
gtgctctcgctctacgcgctgcacgtgaaggcggcgcgcgcccgggaccgggattaccgc
gcgctctgcgacgtgggcaccgccatcagctgttcgcgcgtcttctcctccaggtggggc
aggggtttcgggctggtggagcatgtgctgggacaggacagcatcctcaatcaatccaac
agcatattcggttgcatcttctacacactacagctattgttaggttgcctgcggacacgc
tgggcctctgtcctgatgctgctgagctccctggtgtctctcgctggttctgtctacctg
gcctggatcctgttcttcgtgctctatgatttctgcattgtttgtatcaccacctatgct
atcaacgtgagcctgatgtggctcagtttccggaaggtccaagaaccccagggcaaggct
aagaggcactga |
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