Homo sapiens (human): 79001
Entry
79001 CDS
T01001
Gene name
VKORC1, EDTP308, MST134, MST576, VKCFD2, VKOR
Definition
(RefSeq) vitamin K epoxide reductase complex subunit 1
KO
K05357
vitamin-K-epoxide reductase (warfarin-sensitive) [EC:
1.17.4.4
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00130
Ubiquinone and other terpenoid-quinone biosynthesis
Disease
H00995
Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
H01205
Coumarin resistance
Drug target
Acenocoumarol:
D07064
Clorindione:
D07135
Dicoumarol:
D03798
Diphenadione:
D07136
Ethyl biscoumacetate:
D07131
Flocoumafen:
D07134
Fluindione:
D07969
Phenindion type coumarin derivative (
DG01761
):
D07457
Phenindione:
D08354
Phenprocoumon:
D05457
Tecarfarin (
DG01390
):
D09676
D09677
Tioclomarol:
D07137
Warfarin (
DG00149
):
D00564
D01280
D08682
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
Metabolism
Metabolism of cofactors and vitamins
00130 Ubiquinone and other terpenoid-quinone biosynthesis
79001 (VKORC1)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.17 Acting on CH or CH2 groups
1.17.4 With a disulfide as acceptor
1.17.4.4 vitamin-K-epoxide reductase (warfarin-sensitive)
79001 (VKORC1)
SSDB
Motif
Pfam:
VKOR
Other DBs
NCBI-GeneID:
79001
NCBI-ProteinID:
NP_076869
OMIM:
608547
HGNC:
23663
Ensembl:
ENSG00000167397
Vega:
OTTHUMG00000047408
Pharos:
Q9BQB6
(Tclin)
UniProt:
Q9BQB6
A0A0S2Z6I4
LinkDB
Position
16p11.2
AA seq
163 aa
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH
NT seq
492 nt
+upstream
nt +downstream
nt
atgggcagcacctgggggagccctggctgggtgcggctcgctctttgcctgacgggctta
gtgctctcgctctacgcgctgcacgtgaaggcggcgcgcgcccgggaccgggattaccgc
gcgctctgcgacgtgggcaccgccatcagctgttcgcgcgtcttctcctccaggtggggc
aggggtttcgggctggtggagcatgtgctgggacaggacagcatcctcaatcaatccaac
agcatattcggttgcatcttctacacactacagctattgttaggttgcctgcggacacgc
tgggcctctgtcctgatgctgctgagctccctggtgtctctcgctggttctgtctacctg
gcctggatcctgttcttcgtgctctatgatttctgcattgtttgtatcaccacctatgct
atcaacgtgagcctgatgtggctcagtttccggaaggtccaagaaccccagggcaaggct
aagaggcactga
DBGET
integrated database retrieval system