KEGG   VARIANT: 25v1Help
Entry
25v1                      Variant                                  

Name
BCR-ABL1 fusion
Gene
ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619]
Organism
hsa_var Human gene variants (Homo sapiens)
Variation
translocation t(9;22)(q34;q11)
COSF: 1756 1758 1783
Network
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00055  BCR-ABL fusion kinase to Jak-STAT signaling pathway
N10001  First-generation tyrosine kinase inhibitor to BCR-ABL fusion
Reference
  Authors
Ren R.
  Title
Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia.
  Journal
Nat Rev Cancer 5:172-83 (2005)
DOI:10.1038/nrc1567
Reference
  Authors
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM.
  Title
The biology of chronic myeloid leukemia.
  Journal
N Engl J Med 341:164-72 (1999)
DOI:10.1056/NEJM199907153410306
Reference
  Authors
Salesse S, Verfaillie CM
  Title
BCR/ABL: from molecular mechanisms of leukemia induction to treatment of chronic myelogenous leukemia.
  Journal
Oncogene 21:8547-59 (2002)
DOI:10.1038/sj.onc.1206082
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