KEGG   PATHWAY: mmu04630Help
Entry
mmu04630                    Pathway                                

Name
Jak-STAT signaling pathway - Mus musculus (mouse)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Jak-STAT signaling pathway
mmu04630

All organismsOrtholog table
Module
JAK-STAT signaling [PATH:mmu04630]
Other DBs
BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
16183  
Il2; interleukin 2 [KO:K05429]
16187  
Il3; interleukin 3 [KO:K04736]
16189  
Il4; interleukin 4 [KO:K05430]
16191  
Il5; interleukin 5 [KO:K05428]
16193  
Il6; interleukin 6 [KO:K05405]
16196  
Il7; interleukin 7 [KO:K05431]
16198  
Il9; interleukin 9 [KO:K05432]
16153  
Il10; interleukin 10 [KO:K05443]
16156  
Il11; interleukin 11 [KO:K05417]
16159  
Il12a; interleukin 12a [KO:K05406]
16160  
Il12b; interleukin 12b [KO:K05425]
16163  
Il13; interleukin 13 [KO:K05435]
16168  
Il15; interleukin 15 [KO:K05433]
329244  
Il19; interleukin 19 [KO:K05444]
58181  
Il20; interleukin 20 [KO:K05444]
93672  
Il24; interleukin 24 [KO:K05444]
60505  
Il21; interleukin 21 [KO:K05434]
50929  
Il22; interleukin 22 [KO:K05445]
83430  
Il23a; interleukin 23, alpha subunit p19 [KO:K05426]
239114  
Il17d; interleukin 17D [KO:K05492]
15962  
Ifna1; interferon alpha 1 [KO:K05414]
15965  
Ifna2; interferon alpha 2 [KO:K05414]
15967  
Ifna4; interferon alpha 4 [KO:K05414]
15968  
Ifna5; interferon alpha 5 [KO:K05414]
15969  
Ifna6; interferon alpha 6 [KO:K05414]
15970  
Ifna7; interferon alpha 7 [KO:K05414]
15972  
Ifna9; interferon alpha 9 [KO:K05414]
15964  
Ifna11; interferon alpha 11 [KO:K05414]
242519  
Ifna12; interferon alpha 12 [KO:K05414]
230396  
Ifna13; interferon alpha 13 [KO:K05414]
404549  
Ifna14; interferon alpha 14 [KO:K05414]
15974  
Ifnab; interferon alpha B [KO:K05414]
242517  
Ifna15; interferon alpha 15 [KO:K05414]
15977  
Ifnb1; interferon beta 1, fibroblast [KO:K05415]
15978  
Ifng; interferon gamma [KO:K04687]
230405  
Ifne; interferon epsilon [KO:K05442]
387510  
Ifnk; interferon kappa [KO:K05441]
338374  
Ifnl3; interferon lambda 3 [KO:K05447]
330496  
Ifnl2; interferon lambda 2 [KO:K05447]
18413  
Osm; oncostatin M [KO:K05418]
16878  
Lif; leukemia inhibitory factor [KO:K05419]
53603  
Tslp; thymic stromal lymphopoietin [KO:K05436]
13019  
Ctf1; cardiotrophin 1 [KO:K05422]
12981  
Csf2; colony stimulating factor 2 (granulocyte-macrophage) [KO:K05427]
12803  
Cntf; ciliary neurotrophic factor [KO:K05420]
12985  
Csf3; colony stimulating factor 3 (granulocyte) [KO:K05423]
13856  
Epo; erythropoietin [KO:K05437]
14599  
Gh; growth hormone [KO:K05438]
16846  
Lep; leptin [KO:K05424]
21832  
Thpo; thrombopoietin [KO:K06854]
19109  
Prl; prolactin [KO:K05439]
16184  
Il2ra; interleukin 2 receptor, alpha chain [KO:K05068]
16185  
Il2rb; interleukin 2 receptor, beta chain [KO:K05069]
16186  
Il2rg; interleukin 2 receptor, gamma chain [KO:K05070]
16188  
Il3ra; interleukin 3 receptor, alpha chain [KO:K04737]
16190  
Il4ra; interleukin 4 receptor, alpha [KO:K05071]
16192  
Il5ra; interleukin 5 receptor, alpha [KO:K05067]
16194  
Il6ra; interleukin 6 receptor, alpha [KO:K05055]
16197  
Il7r; interleukin 7 receptor [KO:K05072]
16199  
Il9r; interleukin 9 receptor [KO:K05073]
16154  
Il10ra; interleukin 10 receptor, alpha [KO:K05134]
16155  
Il10rb; interleukin 10 receptor, beta [KO:K05135]
16157  
Il11ra1; interleukin 11 receptor, alpha chain 1 [KO:K05056]
16158  
Il11ra2; interleukin 11 receptor, alpha chain 2 [KO:K05056]
interleukin-11 receptor subunit alpha-2-like; K05056 interleukin 11 receptor alpha [KO:K05056]
Gm13305; predicted gene 13305 [KO:K05056]
Gm2002; predicted gene 2002 [KO:K05056]
16161  
Il12rb1; interleukin 12 receptor, beta 1 [KO:K05063]
16162  
Il12rb2; interleukin 12 receptor, beta 2 [KO:K05064]
16164  
Il13ra1; interleukin 13 receptor, alpha 1 [KO:K05076]
16165  
Il13ra2; interleukin 13 receptor, alpha 2 [KO:K05077]
16169  
Il15ra; interleukin 15 receptor, alpha chain [KO:K05074]
237313  
Il20ra; interleukin 20 receptor, alpha [KO:K05136]
213208  
Il20rb; interleukin 20 receptor beta [KO:K05137]
60504  
Il21r; interleukin 21 receptor [KO:K05075]
230828  
Il22ra1; interleukin 22 receptor, alpha 1 [KO:K05138]
237310  
Il22ra2; interleukin 22 receptor, alpha 2 [KO:K05139]
209590  
Il23r; interleukin 23 receptor [KO:K05065]
50931  
Il27ra; interleukin 27 receptor, alpha [KO:K19598]
16195  
Il6st; interleukin 6 signal transducer [KO:K05060]
15975  
Ifnar1; interferon (alpha and beta) receptor 1 [KO:K05130]
15976  
Ifnar2; interferon (alpha and beta) receptor 2 [KO:K05131]
15979  
Ifngr1; interferon gamma receptor 1 [KO:K05132]
15980  
Ifngr2; interferon gamma receptor 2 [KO:K05133]
242700  
Ifnlr1; interferon lambda receptor 1 [KO:K05140]
18414  
Osmr; oncostatin M receptor [KO:K05057]
16880  
Lifr; leukemia inhibitory factor receptor [KO:K05058]
57914  
Crlf2; cytokine receptor-like factor 2 [KO:K05078]
12804  
Cntfr; ciliary neurotrophic factor receptor [KO:K05059]
12982  
Csf2ra; colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [KO:K05066]
12984  
Csf2rb2; colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) [KO:K04738]
12983  
Csf2rb; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) [KO:K04738]
12986  
Csf3r; colony stimulating factor 3 receptor (granulocyte) [KO:K05061]
13857  
Epor; erythropoietin receptor [KO:K05079]
14600  
Ghr; growth hormone receptor [KO:K05080]
16847  
Lepr; leptin receptor [KO:K05062]
17480  
Mpl; myeloproliferative leukemia virus oncogene [KO:K05082]
19116  
Prlr; prolactin receptor [KO:K05081]
16451  
Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
16452  
Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16453  
Jak3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
54721  
Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
20846  
Stat1; signal transducer and activator of transcription 1 [KO:K11220]
20847  
Stat2; signal transducer and activator of transcription 2 [KO:K11221]
20848  
Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20849  
Stat4; signal transducer and activator of transcription 4 [KO:K11222]
20850  
Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  
Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
20852  
Stat6; signal transducer and activator of transcription 6 [KO:K11225]
12700  
Cish; cytokine inducible SH2-containing protein [KO:K04701]
12703  
Socs1; suppressor of cytokine signaling 1 [KO:K04694]
216233  
Socs2; suppressor of cytokine signaling 2 [KO:K04695]
12702  
Socs3; suppressor of cytokine signaling 3 [KO:K04696]
67296  
Socs4; suppressor of cytokine signaling 4 [KO:K04697]
56468  
Socs5; suppressor of cytokine signaling 5 [KO:K04698]
192157  
Socs7; suppressor of cytokine signaling 7 [KO:K04699]
54607  
Socs6; suppressor of cytokine signaling 6 [KO:K04699]
12043  
Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
17210  
Mcl1; myeloid cell leukemia sequence 1 [KO:K02539]
12048  
Bcl2l1; BCL2-like 1 [KO:K04570]
18712  
Pim1; proviral integration site 1 [KO:K04702] [EC:2.7.11.1]
17869  
Myc; myelocytomatosis oncogene [KO:K04377]
12443  
Ccnd1; cyclin D1 [KO:K04503]
12444  
Ccnd2; cyclin D2 [KO:K10151]
12445  
Ccnd3; cyclin D3 [KO:K10152]
12575  
Cdkn1a; cyclin-dependent kinase inhibitor 1A (P21) [KO:K06625]
213043  
Aox2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
11761  
Aox1; aldehyde oxidase 1 [KO:K00157] [EC:1.2.3.1]
71872  
Aox4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
71724  
Aox3; aldehyde oxidase 3 [KO:K00157] [EC:1.2.3.1]
14580  
Gfap; glial fibrillary acidic protein [KO:K05640]
20844  
Stam; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [KO:K04705]
56324  
Stam2; signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 [KO:K04705]
19255  
Ptpn2; protein tyrosine phosphatase, non-receptor type 2 [KO:K18026] [EC:3.1.3.48]
15170  
Ptpn6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
16391  
Irf9; interferon regulatory factor 9 [KO:K04693]
12914  
Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
328572  
Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
56469  
Pias1; protein inhibitor of activated STAT 1 [KO:K04706]
17344  
Pias2; protein inhibitor of activated STAT 2 [KO:K16063]
229615  
Pias3; protein inhibitor of activated STAT 3 [KO:K16064]
59004  
Pias4; protein inhibitor of activated STAT 4 [KO:K16065]
14199  
Fhl1; four and a half LIM domains 1 [KO:K14365]
19247  
Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
14784  
Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662  
Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663  
Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
15461  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
110157  
Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
30955  
Pik3cg; phosphoinositide-3-kinase, catalytic, gamma polypeptide [KO:K00922] [EC:2.7.1.153]
18706  
Pik3ca; phosphatidylinositol 3-kinase, catalytic, alpha polypeptide [KO:K00922] [EC:2.7.1.153]
18707  
Pik3cd; phosphatidylinositol 3-kinase catalytic delta polypeptide [KO:K00922] [EC:2.7.1.153]
74769  
Pik3cb; phosphatidylinositol 3-kinase, catalytic, beta polypeptide [KO:K00922] [EC:2.7.1.153]
18709  
Pik3r2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) [KO:K02649]
18708  
Pik3r1; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) [KO:K02649]
320207  
Pik3r5; phosphoinositide-3-kinase, regulatory subunit 5, p101 [KO:K02649]
18710  
Pik3r3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) [KO:K02649]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56717  
Mtor; mechanistic target of rapamycin (serine/threonine kinase) [KO:K07203] [EC:2.7.11.1]
Reference
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4 (2012)
Reference
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
Reference
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
Reference
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
Reference
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
Reference
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
Reference
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
Reference
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
Reference
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
Reference
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
Reference
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
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