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spo04120                    Pathway                                

Ubiquitin mediated proteolysis - Schizosaccharomyces pombe (fission yeast)
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Genetic Information Processing; Folding, sorting and degradation
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Pathway map
Ubiquitin mediated proteolysis

All organismsOrtholog table
SCF-MET30 complex [PATH:spo04120]
SCF-BTRC complex [PATH:spo04120]
Cul4-DDB1-CSA complex [PATH:spo04120]
SCF-CDC4 complex [PATH:spo04120]
SCF-GRR1 complex [PATH:spo04120]
Other DBs
Schizosaccharomyces pombe (fission yeast) [GN:spo]
ptr3; ubiquitin activating enzyme E1 [KO:K03178] [EC:]
rad31; SUMO E1-like activator enzyme Rad31 [KO:K10684] [EC:]
fub2; SUMO E1-like activator enzyme Fub2 (predicted) [KO:K10685] [EC:]
uba3; NEDD8 activating enzyme [KO:K10686] [EC:]
rhp6; ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:]
ubc11; ubiquitin conjugating enzyme E2-C, Ubc11 [KO:K06688] [EC:]
ubc4; ubiquitin conjugating enzyme Ubc4 [KO:K06689] [EC:]
ubc14; ubiquitin conjugating enzyme Ubc14 (predicted) [KO:K06689] [EC:]
ubc15; ubiquitin conjugating enzyme Ubc15 [KO:K10575] [EC:]
ubc7; ubiquitin conjugating enzyme Ubc7/UbcP3 [KO:K04555] [EC:]
ubc8; ubiquitin conjugating enzyme Ubc8 (predicted) [KO:K10576] [EC:]
hus5; SUMO conjugating enzyme Hus5 [KO:K10577]
ubc6; ubiquitin conjugating enzyme Ubc6 (predicted) [KO:K04554] [EC:]
ubc12; NEDD8-conjugating enzyme Ubc12 [KO:K10579]
ubc13; ubiquitin conjugating enzyme Ubc13 [KO:K10580] [EC:]
ubc1; ubiquitin conjugating enzyme Ubc1 (predicted) [KO:K04649] [EC:]
ubiquitin-protein ligase E3 (predicted); K10589 ubiquitin-protein ligase E3 C [EC:] [KO:K10589] [EC:]
ubiquitin-protein ligase E3 (predicted); K10590 E3 ubiquitin-protein ligase TRIP12 [EC:] [KO:K10590] [EC:]
pub1; HECT-type ubiquitin-protein ligase E3 Pub1 [KO:K10591] [EC:]
pub2; HECT-type ubiquitin-protein ligase Pub2 [KO:K10591] [EC:]
pub3; HECT-type ubiquitin-protein ligase Pub3 (predicted) [KO:K10591] [EC:]
ptr1; E3 ubiquitin-protein ligase [KO:K10592] [EC:]
ufd2; ubiquitin-protein ligase E4 (predicted) [KO:K10597] [EC:]
cyp8; cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp8 [KO:K10598] [EC:]
prp19; ubiquitin-protein ligase E4 [KO:K10599] [EC:]
pli1; SUMO E3 ligase Pli1 [KO:K04706]
hrd1; ubiquitin-protein ligase Hrd1, synviolin family [KO:K10601] [EC:]
rbx1; RING-box protein 1 [KO:K03868]
cul1; cullin 1 [KO:K03347]
skp1; SCF ubiquitin ligase complex subunit Skp1 [KO:K03094]
pof11; F-box protein Pof11 [KO:K03362]
pop2; F-box/WD repeat protein Pop2 [KO:K03361]
pop1; cullin 1 adaptor protein Pop1 [KO:K03361]
pof1; F-box/WD repeat protein protein Pof1 [KO:K10259]
pof2; F-box protein Pof2 [KO:K03360]
elongin C (predicted); K03872 transcription elongation factor B, polypeptide 1 [KO:K03872]
cul3; cullin 3 [KO:K03869]
pcu4; cullin 4 [KO:K10609]
ddb1; damaged DNA binding protein Ddb1 [KO:K10610]
ckn1; hypothetical protein [KO:K10570]
apc11; anaphase-promoting complex subunit Apc11 [KO:K03358]
apc2; anaphase-promoting complex cullin family subunit Apc2 [KO:K03349]
slp1; WD repeat-containing protein [KO:K03363]
srw1; CDK inhibitor Srw1 [KO:K03364]
mfr1; fizzy-related protein Mfr1 [KO:K03364]
cut4; anaphase-promoting complex subunit Apc1 [KO:K03348]
nuc2; anaphase-promoting complex subunit Apc3 [KO:K03350]
cut20; anaphase-promoting complex subunit Apc4 [KO:K03351]
apc5; anaphase-promoting complex subunit Apc5 [KO:K03352]
cut9; anaphase-promoting complex subunit Cut9 [KO:K03353]
cut23; anaphase-promoting complex subunit Apc8 [KO:K03355]
apc10; anaphase-promoting complex subunit Apc10 [KO:K03357]
PMID:16922370 (Japanese)
Kamura T.
[Cullin-based E3 family] Japanese
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
PMID:16922408 (Japanese)
Matsuda N.
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
PMID:16922367 (Japanese)
Tokunaga F.
[E2 ubiquitin-conjugating enzymes: structures and functions]
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Nalepa G, Rolfe M, Harper JW.
Drug discovery in the ubiquitin-proteasome system.
Nat Rev Drug Discov 5:596-613 (2006)
Hsu YJ, Goodman SR.
Spectrin and ubiquitination: a review.
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Hatakeyama S, Nakayama KI.
Ubiquitylation as a quality control system for intracellular proteins.
J Biochem 134:1-8 (2003)
Lee J, Zhou P.
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
Mol Cell 26:775-80 (2007)
KO pathway
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