KEGG   PATHWAY: stt00540Help
Entry
stt00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Salmonella enterica subsp. enterica serovar Typhi Ty2
Class
Metabolism; Glycan biosynthesis and metabolism
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Pathway map
Lipopolysaccharide biosynthesis
stt00540

All organismsOrtholog table
Module
Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:stt00540]
CMP-KDO biosynthesis [PATH:stt00540]
ADP-L-glycero-D-manno-heptose biosynthesis [PATH:stt00540]
Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen [PATH:stt00540]
Other DBs
BSID: 
GO: 
Organism
Salmonella enterica subsp. enterica serovar Typhi Ty2 [GN:stt]
Gene
t0229  
lpxA; acyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
t0138  
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
t0227  
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
t2326  
ybbF; conserved hypothetical protein [KO:K03269] [EC:3.6.1.54]
t0230  
lpxB; lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
t1949  
lpxK; tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
t3232  
conserved hypothetical protein [KO:K06041] [EC:5.3.1.13]
t1104  
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
t3233  
conserved hypothetical protein [KO:K03270] [EC:3.1.3.45]
t1946  
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
t3794  
kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
t1765  
htrB; lipid A biosynthesis lauroyl acyltransferase [KO:K02517] [EC:2.3.1.241]
t0988  
msbB; lipid A acyltransferase [KO:K02560] [EC:2.3.1.243]
t2540  
gmhA; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
t3120  
rfaE; ADP-heptose synthase [KO:K03272] [EC:2.7.7.70 2.7.1.167]
t0251  
yaeD; conserved hypothetical protein [KO:K03273] [EC:3.1.3.83 3.1.3.82]
t3809  
rfaD; ADP-L-Glycero-D-mannoheptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
t3804  
waaZ; lipopolysaccharide core biosynthesis protein RfaZ [KO:K12981] [EC:2.4.99.-]
t3807  
waaC; lipopolysaccharide heptosyltransferase-1 [KO:K02841] [EC:2.4.-.-]
t3808  
waaF; ADP-heptose-LPS heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
t3796  
waaG; lipopolysaccharide core biosynthesis protein [KO:K02844] [EC:2.4.1.-]
t3803  
waaY; lipopolysaccharide core biosynthesis protein [KO:K02850] [EC:2.7.1.-]
t3797  
waaP; lipopolysaccharide core biosynthesis protein [KO:K02848] [EC:2.7.1.-]
t3795  
waaQ; lipopolysaccharide core biosynthesis protein [KO:K02849] [EC:2.4.-.-]
t3800  
waaB; lipopolysaccharide 1,6-galactosyltransferase [KO:K02840] [EC:2.4.1.-]
t3879  
yhjW; putative membrane protein [KO:K12975] [EC:2.7.8.42]
t3506  
yijP; putative membrane protein [KO:K19353] [EC:2.7.8.-]
t3801  
waaI; lipopolysaccharide 1,3-galactosyltransferase [KO:K03278] [EC:2.4.1.44]
t3802  
waaJ; lipopolysaccharide 1,2-glucosyltransferase [KO:K03279] [EC:2.4.1.58]
t3805  
waaK; lipopolysaccharide 1,2-N-acetylglucosaminetransferase [KO:K03280] [EC:2.4.1.56]
t3806  
waaL; O-antigen ligase [KO:K02847] [EC:2.4.1.-]
Compound
C00043  
UDP-N-acetyl-alpha-D-glucosamine
C00199  
D-Ribulose 5-phosphate
C00229  
Acyl-carrier protein
C01112  
D-Arabinose 5-phosphate
C01187  
3-Deoxy-D-manno-octulosonate
C04121  
CMP-3-deoxy-D-manno-octulosonate
C04478  
3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  
UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  
Lipid X
C04919  
2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  
Lipid A disaccharide
C05223  
Dodecanoyl-[acyl-carrier protein]
C05382  
Sedoheptulose 7-phosphate
C05761  
Tetradecanoyl-[acp]
C06022  
UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  
3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  
Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  
Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  
Lauroyl-KDO2-lipid IV(A)
C06397  
ADP-D-glycero-beta-D-manno-heptose
C06398  
ADP-L-glycero-beta-D-manno-heptose
C07836  
D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  
D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  
D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  
4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  
D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  
D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  
D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  
GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
 
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