KEGG   PATHWAY: ypi00540Help
Entry
ypi00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Yersinia pseudotuberculosis IP 31758 (serotype O:1b)
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
ypi00540  Lipopolysaccharide biosynthesis
ypi00540

Ortholog table
Module
ypi_M00060  Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:ypi00540]
ypi_M00063  CMP-KDO biosynthesis [PATH:ypi00540]
ypi_M00064  ADP-L-glycero-D-manno-heptose biosynthesis [PATH:ypi00540]
Other DBs
BSID: 56289
GO: 0009103
Organism
Yersinia pseudotuberculosis IP 31758 (serotype O:1b) [GN:ypi]
Gene
YpsIP31758_1025  lpxA; acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
YpsIP31758_3381  lpxC; UDP-3-0-acyl N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
YpsIP31758_1023  lpxD; UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
YpsIP31758_3016  lpxH; UDP-2,3-diacylglucosamine hydrolase [KO:K03269] [EC:3.6.1.54]
YpsIP31758_1026  lpxB; lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
YpsIP31758_2576  lpxK; tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
YpsIP31758_0446  kdsD; arabinose 5-phosphate isomerase [KO:K06041] [EC:5.3.1.13]
YpsIP31758_2062  kdsA; 3-deoxy-8-phosphooctulonate synthase [KO:K01627] [EC:2.5.1.55]
YpsIP31758_0445  kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase [KO:K03270] [EC:3.1.3.45]
YpsIP31758_2571  kdsB; 3-deoxy-D-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
YpsIP31758_0067  kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
YpsIP31758_1556  htrB1; lipid A biosynthesis lauroyl acyltransferase [KO:K02517] [EC:2.3.1.241]
YpsIP31758_2025  msbB; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [KO:K02560] [EC:2.3.1.243]
YpsIP31758_3170  gmhA1; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
YpsIP31758_0564  hldE; bifunctional protein HldE [KO:K03272] [EC:2.7.7.70 2.7.1.167]
YpsIP31758_1044  gmhB; D,D-heptose 1,7-bisphosphate phosphatase [KO:K03273] [EC:3.1.3.83 3.1.3.82]
YpsIP31758_0070  rfaD; ADP-L-glycero-D-manno-heptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
YpsIP31758_0068  rfaC; lipopolysaccharide heptosyltransferase I [KO:K02841] [EC:2.4.-.-]
YpsIP31758_0069  rfaF; lipopolysaccharide heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
YpsIP31758_3516  putative lipopolysaccharide heptosyltransferase III [KO:K02849] [EC:2.4.-.-]
YpsIP31758_4081  eptB; phosphoethanolamine transferase [KO:K12975] [EC:2.7.8.42]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
ko00540   
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