{
	"name":"apt03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"APA01_08070 ubiquinol-cytochrome c reductase cytochrome b\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				},
				{
					"name":"APA01_18590 ubiquinol-cytochrome c reductase cytochrome b\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"APA01_25020 translation initiation Factor 2 (IF-2)\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"APA01_19670 translation initiation Factor 3 (IF-3)\tK02520 infC; translation initiation factor IF-3"
				},
				{
					"name":"APA01_19420 translation elongation factor Ts (EF-Ts)\tK02357 tsf; elongation factor Ts"
				},
				{
					"name":"APA01_09310 translation elongation factor Tu (EF-TU)\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"APA01_16670 translation elongation factor G (EF-G)\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP"
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"APA01_00960 DNA helicase\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"APA01_01070 suv3; RNA helicase\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"APA01_06490 era; GTP-binding protein Era\tK03595 era; GTPase"
				},
				{
					"name":"APA01_25860 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"APA01_25480 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"APA01_03690 aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"APA01_21180 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"APA01_12870 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"APA01_20770 amidase\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"APA01_25370 amidotransferase A subunit for Asp-tRNA(Asn)\/Glu-tRNA(Gln)\tK02433 gatA; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"APA01_25380 glutamyl-tRNA(Gln) amidotransferase subunit B\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"APA01_25360 glutamyl-tRNA(Gln) amidotransferase subunit C\tK02435 gatC; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors",
				"children":[
				{
					"name":"APA01_03550 endonuclease\tK01173 ENDOG; endonuclease G, mitochondrial"
				}
				]
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"APA01_25720 ssb; single-strand DNA binding protein Ssb\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors"
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex"
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"APA01_06560 outer membrane protein\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex"
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex"
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors"
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"APA01_02900 dnaK; heat shock protein DnaK\/Hsp70\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"APA01_02890 grpE; heat shock protein GrpE\tK03687 GRPE; molecular chaperone GrpE"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"APA01_17870 groEL; heat shock protein GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"APA01_17860 groES; heat shock protein GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"APA01_02910 dnaJ; heat shock protein DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"APA01_16670 translation elongation factor G (EF-G)\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"APA01_26010 nifS; cysteine desulfurase II NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"APA01_26020 nifS; cysteine desulfurase I NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"APA01_02900 dnaK; heat shock protein DnaK\/Hsp70\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"APA01_12000 glutaredoxin\tK07390 grxD; monothiol glutaredoxin"
				},
				{
					"name":"APA01_11130 bolA; stress response and cell division protein BolA\tK22066 BOLA1; BolA-like protein 1"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis"
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors",
				"children":[
				{
					"name":"APA01_24890 apbC; iron-sulfur cluster assembly\/repair protein ApbC\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				}
				]
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"APA01_16820 protoheme IX farnesyltransferase\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"APA01_00780 cytochrome c oxidase assembly protein\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"APA01_06660 yidC; translocase inner membrane component YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"APA01_20910 sco1_senC; electron transport transmembrane protein Sco1\/SenC\/PrrC\tK07152 SCO1; protein SCO1"
				},
				{
					"name":"APA01_21440 sco1_senC; electron transport transmembrane protein Sco1\/SenC\/PrrC\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors"
			},
			{
				"name":"Actin cytoskeleton organization"
			},
			{
				"name":"Mitochondrial movement"
			},
			{
				"name":"Retention of mitochondria"
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins"
			},
			{
				"name":"Parkin-dependent mechanism factors"
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"APA01_03340 htpG; heat shock protein HtpG\/Hsp90\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors"
			}
			]
		}
		]
	}
	]
}