{
	"name":"ero03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors",
					"children":[
					{
						"name":"EROM_100260 mRNA capping enzyme\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"
					},
					{
						"name":"EROM_021360 Kin28-like Ser\/Thr protein kinase\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"EROM_090400 mRNA capping enzyme subunit alpha\tK00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]"
					}
					]
				},
				{
					"name":"Cap binding complex",
					"children":[
					{
						"name":"EROM_030640 putative RNA-binding protein\tK12883 NCBP2; nuclear cap-binding protein subunit 2"
					}
					]
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)",
					"children":[
					{
						"name":"EROM_051160 pre-mRNA cleavage complex GTPase subunit\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]"
					}
					]
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex",
					"children":[
					{
						"name":"EROM_110470 pre-mRNA cleavage and polyadenylation\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1"
					},
					{
						"name":"EROM_050360 putative cleavage and polyadenylation\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"EROM_100780 putative beta-lactamase fold-containing exonuclease\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"EROM_010210 zinc finger domain-containing protein\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4"
					},
					{
						"name":"EROM_111280 polyadenylation factor I complex subunit Fip1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1"
					},
					{
						"name":"EROM_090330 RING zinc finger domain-containing protein\tK15541 MPE1; protein MPE1"
					},
					{
						"name":"EROM_021310 WD40 domain-containing protein\tK15542 PFS2; polyadenylation factor subunit 2"
					},
					{
						"name":"EROM_041610 hypothetical protein\tK14962 WDR82; COMPASS component SWD2"
					},
					{
						"name":"EROM_110530 Ser\/Thr protein phosphatase PPI-1\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"EROM_060780 Ssu72-like protein\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex",
					"children":[
					{
						"name":"EROM_080300 cleavage stimulation factor\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"EROM_060710 hypothetical protein\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors",
					"children":[
					{
						"name":"EROM_080470 U6 snRNA-associated Sm-like protein\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"EROM_030720 small nuclear D3-like ribonucleoprotein\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"EROM_020930 small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"EROM_040730 small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"EROM_050940 small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"EROM_050360 putative cleavage and polyadenylation\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"EROM_100780 putative beta-lactamase fold-containing exonuclease\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"EROM_080300 cleavage stimulation factor\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"EROM_060710 hypothetical protein\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"EROM_081660 transcription elongation factor Spt4\tK15171 SUPT4H1; transcription elongation factor SPT4"
					},
					{
						"name":"EROM_111820 transcription elongation factor Spt5\tK15172 SUPT5H; transcription elongation factor SPT5"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors",
					"children":[
					{
						"name":"EROM_020650 poly (A) polymerase type 1\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]"
					}
					]
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex",
					"children":[
					{
						"name":"EROM_061540 WD40 domain-containing protein\tK14298 RAE1; mRNA export factor"
					},
					{
						"name":"EROM_111340 protein transport Sec13-like protein\tK14004 SEC13; protein transport protein SEC13"
					},
					{
						"name":"EROM_020370 nucleoporin autopeptidase\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96"
					},
					{
						"name":"EROM_060400 nuclear pore complex protein Nup155\tK14312 NUP155; nuclear pore complex protein Nup155"
					}
					]
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"EROM_041590 GTP-binding nuclear protein\tK07936 RAN; GTP-binding nuclear protein Ran"
					},
					{
						"name":"EROM_011050 Cdc48-like AAA ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"EROM_110110 exportin 1\tK14290 XPO1; exportin-1"
					},
					{
						"name":"EROM_050630 RAN specific GTPase-activating protein\tK14319 RANGAP1; Ran GTPase-activating protein 1"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins",
					"children":[
					{
						"name":"EROM_080870 eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"EROM_111240 eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"EROM_090570 eukaryotic translation initiation factor 4A\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"EROM_041640 transcription initiation factor 4F subunit-like protein\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"EROM_100990 polyadenylate-binding protein 2\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"EROM_070780 Ski2-like ATP-dependent RNA helicase\tK18664 SLH1; antiviral helicase SLH1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"EROM_031250 pelota-like RNA-binding protein\tK06965 PELO; protein pelota"
					},
					{
						"name":"EROM_010320 RNA-binding protein\tK14396 PABPN1; polyadenylate-binding protein 2"
					},
					{
						"name":"EROM_021430 ATP-dependent RNA helicase\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]"
					},
					{
						"name":"EROM_041530 alpha-tubulin suppressor-like protein\tK11493 RCC1; regulator of chromosome condensation"
					},
					{
						"name":"EROM_060200 hypothetical protein\tK22415 ZC3H11; zinc finger CCCH domain-containing protein 11"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"EROM_050330 peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1"
					},
					{
						"name":"EROM_061420 translation elongation factor 1-alpha\tK03267 ERF3; peptide chain release factor subunit 3"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A",
					"children":[
					{
						"name":"EROM_040630 Ser\/Thr protein phosphatase 2A\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"EROM_090890 putative protein phosphatase\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"EROM_050820 Ser\/Thr protein phosphatase PP2-A regulatory subunit B\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"EROM_040170 Ser\/Thr protein phosphatase 2A regulatory subunit beta\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"EROM_041080 translation elongation factor EF-1 alpha\tK03231 EEF1A; elongation factor 1-alpha"
					}
					]
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule",
					"children":[
					{
						"name":"EROM_080870 eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"EROM_111240 eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"EROM_091630 ATP-dependent RNA helicase\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"EROM_100440 ribosomal protein S6 kinase\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					}
					]
				},
				{
					"name":"P-body specific factors",
					"children":[
					{
						"name":"EROM_071550 mRNA decapping enzyme 2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"EROM_051380 U6 snRNA-associated small Sm-like protein\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"EROM_091830 U6 snRNA-associated ribonucleoprotein\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"EROM_030260 U6 snRNA associated Sm-like protein\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"EROM_061090 U6-snRNA associated small nuclear ribonucleoprotein\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"EROM_110500 U6 snRNA-associated Sm-like protein\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"EROM_071130 alpha-tubulin\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"EROM_111260 cell division control negative transcription regulator\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"EROM_010840 general negative regulator of transcription\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"EROM_110640 glucose-repressible alcohol dehydrogenase transcriptional effector\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"EROM_080820 mRNA deadenylase subunit\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"EROM_071670 DNA-directed RNA polymerase II subunit E'\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
					}
					]
				},
				{
					"name":"Stress granule specific factors",
					"children":[
					{
						"name":"EROM_100990 polyadenylate-binding protein 2\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"EROM_110540 hypothetical protein\tK15026 EIF2A; translation initiation factor 2A"
					},
					{
						"name":"EROM_090570 eukaryotic translation initiation factor 4A\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"EROM_041640 transcription initiation factor 4F subunit-like protein\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"EROM_081120 WD40 domain-containing putative guanine nucleotide binding protein\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex",
					"children":[
					{
						"name":"EROM_071550 mRNA decapping enzyme 2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"EROM_091630 ATP-dependent RNA helicase\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					}
					]
				},
				{
					"name":"Lsm complex",
					"children":[
					{
						"name":"EROM_051380 U6 snRNA-associated small Sm-like protein\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"EROM_091830 U6 snRNA-associated ribonucleoprotein\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"EROM_030260 U6 snRNA associated Sm-like protein\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"EROM_061090 U6-snRNA associated small nuclear ribonucleoprotein\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"EROM_110500 U6 snRNA-associated Sm-like protein\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					}
					]
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors",
					"children":[
					{
						"name":"EROM_101610 hypothetical protein\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					}
					]
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors",
					"children":[
					{
						"name":"EROM_101230 Rrp4-like RNA-binding protein\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"EROM_090610 S1-like RNA-binding domain-containing protein\tK03681 RRP40; exosome complex component RRP40"
					},
					{
						"name":"EROM_091230 ribonuclease\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"EROM_100140 exosome RNAse PH-like protein\tK12590 RRP46; exosome complex component RRP46"
					},
					{
						"name":"EROM_111950 hypothetical protein\tK12586 RRP43; exosome complex component RRP43"
					},
					{
						"name":"EROM_060300 RNase PH-like exoribonuclease\tK03678 RRP45; exosome complex component RRP45"
					}
					]
				},
				{
					"name":"Exosome cofactors",
					"children":[
					{
						"name":"EROM_111020 hypothetical protein\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]"
					},
					{
						"name":"EROM_050970 putative Ski2 RNA helicase\tK20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]"
					}
					]
				},
				{
					"name":"TRAMP complex",
					"children":[
					{
						"name":"EROM_061510 DNA polymerase sigma\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
					},
					{
						"name":"EROM_110520 arginine methyltransferase-interacting protein\tK12597 AIR1_2; protein AIR1\/2"
					},
					{
						"name":"EROM_040850 Ski2 ATP-dependent RNA helicase\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex",
					"children":[
					{
						"name":"EROM_110640 glucose-repressible alcohol dehydrogenase transcriptional effector\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"EROM_111260 cell division control negative transcription regulator\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"EROM_010840 general negative regulator of transcription\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"EROM_080820 mRNA deadenylase subunit\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"EROM_010160 putative Rcd1-like protein\tK12606 RCD1; CCR4-NOT transcription complex subunit 9"
					}
					]
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors",
					"children":[
					{
						"name":"EROM_101610 hypothetical protein\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					}
					]
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases"
				},
				{
					"name":"Helicases"
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"EROM_101580 enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"EROM_030580 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"EROM_110400 molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
					}
					]
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome",
					"children":[
					{
						"name":"EROM_101230 Rrp4-like RNA-binding protein\tK03679 RRP4; exosome complex component RRP4"
					}
					]
				},
				{
					"name":"Cofactors",
					"children":[
					{
						"name":"EROM_091230 ribonuclease\tK11600 RRP41; exosome complex component RRP41"
					}
					]
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}