{
	"name":"mgik01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"GO620_005740 TCR\/Tet family MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				},
				{
					"name":"GO620_005745 TCR\/Tet family MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"GO620_010890 CatB-related O-acetyltransferase\tK18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"GO620_005035 chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"GO620_013810 M48 family metalloprotease\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"GO620_016040 TonB family protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"GO620_013805 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"GO620_016035 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"GO620_011705 M15 family metallopeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"GO620_007615 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"GO620_010675 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"GO620_012860 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"GO620_015375 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"GO620_007610 multidrug efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"GO620_010680 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"GO620_012000 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"GO620_012855 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"GO620_015370 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"GO620_012850 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"GO620_012850 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"GO620_012850 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"GO620_003075 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_007620 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_007710 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_008060 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_010685 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_014895 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_015365 TolC family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"GO620_003075 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_007620 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_007710 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_008060 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_010685 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_014895 TolC family protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"GO620_015365 TolC family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}