{
	"name":"spik02022",
	"children":[
	{
		"name":"OmpR family",
		"children":[
		{
			"name":"PhoR-PhoB (phosphate starvation response)",
			"children":[
			{
				"name":"EXU85_22245 HAMP domain-containing histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_32345 HAMP domain-containing histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_32980 HAMP domain-containing histidine kinase\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_34220 GHKL domain-containing protein\tK07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_34215 response regulator transcription factor\tK07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP"
			}
			]
		},
		{
			"name":"SenX3-RegX3 (phosphate starvation response)"
		},
		{
			"name":"PhoQ-PhoP (magnesium transport)"
		},
		{
			"name":"EnvZ-OmpR (osmotic stress response)"
		},
		{
			"name":"RstB-RstA"
		},
		{
			"name":"CpxA-CpxR (envelope stress response)"
		},
		{
			"name":"CssS-CssR (secretion stress response)"
		},
		{
			"name":"CreC-CreB (phosphate regulation)"
		},
		{
			"name":"BaeS-BaeR (envelope stress response)"
		},
		{
			"name":"BasS-BasR (antimicrobial peptide resistance)"
		},
		{
			"name":"CusS-CusR (copper tolerance)",
			"children":[
			{
				"name":"EXU85_04390 response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"EXU85_05195 response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			},
			{
				"name":"EXU85_27740 response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
			}
			]
		},
		{
			"name":"CrdS-CrdR (copper resistance)"
		},
		{
			"name":"HprS-HprR (hydrogen peroxide response)"
		},
		{
			"name":"QseC-QseB (quorum sensing)"
		},
		{
			"name":"KdpD-KdpE (potassium transport)",
			"children":[
			{
				"name":"EXU85_26375 sensor protein KdpD\tK07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"TorS-TorR (TMAO respiration)"
		},
		{
			"name":"ArcB-ArcA (anoxic redox control)"
		},
		{
			"name":"TctE-TctD (tricarboxylic acid transport)"
		},
		{
			"name":"ResE-ResD (aerobic and anaerobic respiration)"
		},
		{
			"name":"VicK-VicR (cell wall metabolism)"
		},
		{
			"name":"MprB-MprA (maintenance of persistent infection)"
		},
		{
			"name":"MtrB-MtrA (osmotic stress response)"
		},
		{
			"name":"PrrB-PrrA (intracellular multiplication)"
		},
		{
			"name":"TrcS-TrcR"
		},
		{
			"name":"NrsS-NrsR (nickel tolerance)"
		},
		{
			"name":"ManS-ManR (manganese homeostasis)"
		},
		{
			"name":"NblS-NblR (photosynthesis)"
		},
		{
			"name":"SasA-RpaAB (circadian timing mediating)"
		},
		{
			"name":"SaeS-SaeR (staphylococcal virulence regulation)"
		},
		{
			"name":"BceS-BceR (bacitracin transport)"
		},
		{
			"name":"BraS-BraR (bacitracin transport)"
		},
		{
			"name":"GraS-GraR (cationic antimicrobial peptide transport)"
		},
		{
			"name":"YxdK-YxdJ (antimicrobial peptide response)"
		},
		{
			"name":"ChvG-ChvI (acidity sensing)"
		},
		{
			"name":"CiaH-CiaR"
		},
		{
			"name":"ParS-ParR (polymyxin-adaptive resistance)"
		},
		{
			"name":"AdeS-AdeR"
		},
		{
			"name":"VanS-VanR (VanB type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (VanE type vancomycin resistance)"
		},
		{
			"name":"VanS-VanR (actinomycete type vancomycin resistance)"
		},
		{
			"name":"ArlS-ArlR (virulence regulation)"
		},
		{
			"name":"Ihk-Irr (virulence regulation)"
		},
		{
			"name":"PfeS-PfeR (enterobactin-dependent iron acquisition)"
		},
		{
			"name":"NisK-NisR (lantibiotic biosynthesis)"
		},
		{
			"name":"QarB-QarCA (disk-forming signal response)"
		},
		{
			"name":"HssS-HssR (heme sensing)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"EXU85_05070 response regulator transcription factor\tK02483 K02483; two-component system, OmpR family, response regulator"
			},
			{
				"name":"EXU85_22330 response regulator\tK02483 K02483; two-component system, OmpR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NarL family",
		"children":[
		{
			"name":"NarX-NarL (nitrate respiration)"
		},
		{
			"name":"NarQ-NarP (nitrate respiration)"
		},
		{
			"name":"UhpB-UhpA (hexose phosphates uptake)"
		},
		{
			"name":"FusK-FusR (virulence regulation)"
		},
		{
			"name":"RcsC-RcsD-RcsB (capsule synthesis)"
		},
		{
			"name":"BarA-UvrY (central carbon metabolism)",
			"children":[
			{
				"name":"EXU85_25750 response regulator transcription factor\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			},
			{
				"name":"EXU85_25770 response regulator transcription factor\tK07689 uvrY; two-component system, NarL family, invasion response regulator UvrY"
			}
			]
		},
		{
			"name":"ComP-ComA (competence)"
		},
		{
			"name":"EvgS-EvgA (acid and drug tolerance)"
		},
		{
			"name":"DegS-DegU (multicellular behavior control)",
			"children":[
			{
				"name":"EXU85_02125 response regulator transcription factor\tK07692 degU; two-component system, NarL family, response regulator DegU"
			}
			]
		},
		{
			"name":"DesK-DesR (membrane lipid fluidity regulation)"
		},
		{
			"name":"VraS-VraR (cell-wall peptidoglycan synthesis)"
		},
		{
			"name":"LiaS-LiaR (cell wall stress response)"
		},
		{
			"name":"DevS-DevR (redox response)"
		},
		{
			"name":"NreB-NreC (dissimilatory nitrate\/nitrite reduction)",
			"children":[
			{
				"name":"EXU85_34355 response regulator transcription factor\tK07696 nreC; two-component system, NarL family, response regulator NreC"
			}
			]
		},
		{
			"name":"YdfH-YdfI"
		},
		{
			"name":"SalK-SalR"
		},
		{
			"name":"PprA–PprB (biofilm formation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"EXU85_02130 sensor histidine kinase\tK02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Spo family",
		"children":[
		{
			"name":"KinABCDE-Spo0FA (sporulation control)"
		}
		]
	},
	{
		"name":"CitB family",
		"children":[
		{
			"name":"CitA-CitB (citrate fermentation)"
		},
		{
			"name":"CitS-CitT (magnesium-citrate transport)"
		},
		{
			"name":"DcuS-DcuR (C4-dicarboxylate metabolism)"
		},
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"MalK-MalR (malate transport)"
		},
		{
			"name":"Unclassified"
		}
		]
	},
	{
		"name":"LytTR family",
		"children":[
		{
			"name":"LysS-LysR"
		},
		{
			"name":"AlgZ-AlgR (alginate production)",
			"children":[
			{
				"name":"EXU85_02405 sensor protein lytS\tK08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"NatK-NatR (sodium extrusion)"
		},
		{
			"name":"AgrC-AgrA (exoprotein synthesis)"
		},
		{
			"name":"AgrC2-AgrA2 (virulence regulation)"
		},
		{
			"name":"ComD-ComE (competence)"
		},
		{
			"name":"BtsS-BtsR (pyruvate reutilization)"
		},
		{
			"name":"PyrS-PyrR (pyruvate reutilization)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"EXU85_01035 sensor protein lytS\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_07120 sensor histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_16255 histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_17435 sensor histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_20100 sensor histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_21610 hypothetical protein\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_23555 histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_24130 histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_25415 histidine kinase\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_27260 hypothetical protein\tK02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_02060 LytTR family transcriptional regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_02475 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_03520 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_05420 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_05680 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_07115 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_08145 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_08735 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_09300 response regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_12955 response regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_14650 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_15120 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_16260 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_16355 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_16605 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_17440 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_18740 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_19095 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_20095 response regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_21395 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_23730 LytTR family transcriptional regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_24135 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_25025 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_25410 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_27265 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_28315 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_28775 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_29615 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_30355 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_30880 response regulator transcription factor\tK02477 K02477; two-component system, LytTR family, response regulator"
			},
			{
				"name":"EXU85_31475 LytTR family transcriptional regulator\tK02477 K02477; two-component system, LytTR family, response regulator"
			}
			]
		}
		]
	},
	{
		"name":"NtrC family",
		"children":[
		{
			"name":"GlnL-GlnG (nitrogen regulation)"
		},
		{
			"name":"NtrY-NtrX (nitrogen regulation)"
		},
		{
			"name":"HydH-HydG (metal tolerance)",
			"children":[
			{
				"name":"EXU85_04905 sigma-54-dependent Fis family transcriptional regulator\tK07713 zraR; two-component system, NtrC family, response regulator HydG"
			},
			{
				"name":"EXU85_22325 sigma-54-dependent Fis family transcriptional regulator\tK07713 zraR; two-component system, NtrC family, response regulator HydG"
			}
			]
		},
		{
			"name":"AtoS-AtoC (cPHB biosynthesis)",
			"children":[
			{
				"name":"EXU85_23010 sigma-54-dependent Fis family transcriptional regulator\tK07714 atoC; two-component system, NtrC family, response regulator AtoC"
			}
			]
		},
		{
			"name":"PilS-PilR (type 4 fimbriae synthesis)"
		},
		{
			"name":"GlrK-GlrR (amino sugar metabolism)"
		},
		{
			"name":"PgtB-PgtA (phosphoglycerate transport)"
		},
		{
			"name":"DctB-DctD (C4-dicarboxylate transport)"
		},
		{
			"name":"KinB-AlgB (alginate production)",
			"children":[
			{
				"name":"EXU85_26380 HAMP domain-containing protein\tK11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"HupT-HupR (hydrogenase synthesis regulation)"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"EXU85_33345 GHKL domain-containing protein\tK02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"CheA family",
		"children":[
		{
			"name":"CheA-CheYBV (chemotaxis)",
			"children":[
			{
				"name":"EXU85_10420 chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"EXU85_14440 chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			},
			{
				"name":"EXU85_25275 chemotaxis protein CheB\tK03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase\/glutaminase [EC:3.1.1.61 3.5.1.44]"
			}
			]
		},
		{
			"name":"ChpA-ChpB\/PilGH (chemosensory)"
		},
		{
			"name":"PixL-PixGH (positive phototaxis)"
		},
		{
			"name":"WspE-WspRF (chemosensory)"
		},
		{
			"name":"Cph1-Rcp1 (light response)",
			"children":[
			{
				"name":"EXU85_27975 GAF domain-containing protein\tK11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]"
			}
			]
		}
		]
	},
	{
		"name":"Cell cycle family",
		"children":[
		{
			"name":"PleC-PleD (cell fate control)"
		},
		{
			"name":"CckA-CtrA\/CpdR (cell cycle control)"
		},
		{
			"name":"Hk1-Rrp1 (glycerol uptake and utilization)"
		}
		]
	},
	{
		"name":"Lux family",
		"children":[
		{
			"name":"LuxQN\/CqsS-LuxU-LuxO (quorum sensing)"
		}
		]
	},
	{
		"name":"LuxR family",
		"children":[
		{
			"name":"DctS-DctR (C4-dicarboxylate transport)"
		},
		{
			"name":"TtrS-TtrR (tetrathionate respiration)"
		},
		{
			"name":"FixL-FixJ (nitrogen fixation)"
		},
		{
			"name":"SsrA-SsrB"
		}
		]
	},
	{
		"name":"Other families",
		"children":[
		{
			"name":"FlrB-FlrC (polar flagellar synthesis)"
		},
		{
			"name":"AauS-AauR (acidic amino acids utilization)"
		},
		{
			"name":"SLN1-YPD1-SSK1\/SKN7 (osmosensing)"
		},
		{
			"name":"RpfC-RpfG (cell-to-cell signaling)"
		},
		{
			"name":"GlnK-GlnL (glutamine utilization)"
		},
		{
			"name":"HspS-HspR (hexose phosphates uptake)"
		},
		{
			"name":"YesM-YesN"
		},
		{
			"name":"CikA"
		},
		{
			"name":"RegB-RegA (redox response)"
		},
		{
			"name":"FitF-FitH (insecticidal toxin regulation)"
		},
		{
			"name":"PhcS-PhcRQ"
		},
		{
			"name":"SagS-HptB-HsbR (swarming activity and biofilm formation)"
		},
		{
			"name":"PdtaS-PdtaR",
			"children":[
			{
				"name":"EXU85_26120 tetratricopeptide repeat protein\tK00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_26125 sensor histidine kinase\tK00936 pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]"
			}
			]
		},
		{
			"name":"NasS-NasT"
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"EXU85_24590 histidine kinase\tK20971 ladS; two-component system, sensor histidine kinase LadS"
			},
			{
				"name":"EXU85_30905 histidine kinase\tK20971 ladS; two-component system, sensor histidine kinase LadS"
			},
			{
				"name":"EXU85_14435 response regulator\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_22000 hybrid sensor histidine kinase\/response regulator\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_24525 response regulator\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			},
			{
				"name":"EXU85_30770 hybrid sensor histidine kinase\/response regulator\tK11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]"
			}
			]
		}
		]
	}
	]
}