| |
Comment |
 CYP inhbitors
|
CYP1A2 [HSA:1544]
|
 Aciclovir [DG:DG00406]
|
Weak (in vivo) |
Allopurinol
|
Weak (in vivo) |
Amiodarone [DG:DG00204]
|
Weak (in vivo) |
Anastrozole
|
Caffeine
|
Weak (in vivo) |
Cimetidine [DG:DG00017]
|
Weak (in vivo) |
 D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Strong (in vivo) |
Clinafloxacin
|
Daidzein
|
Weak (in vivo) |
Deferasirox
|
Disulfiram
|
Weak (in vivo) |
Echinacea
|
Weak (in vivo) |
Enoxacin [DG:DG00619]
|
Strong (in vivo) |
Etintidine
|
Famotidine
|
Weak (in vivo) |
Fluvoxamine [DG:DG00946]
|
Strong (in vivo) |
Grepafloxacin [DG:DG00623]
|
Idrocilamide
|
Methoxsalen
|
Moderate (in vivo) |
Mexiletine [DG:DG00197]
|
Moderate (in vivo) |
Mibefradil [DG:DG00328]
|
Norfloxacin [DG:DG00620]
|
Weak (in vivo) |
Pefloxacin
|
Peginterferon alfa-2a
|
Phenylpropanolamine
|
Moderate (in vivo) |
Pipemidic acid [DG:DG00631]
|
Piperine
|
Propafenone [DG:DG00200]
|
Weak (in vivo) |
Propranolol [DG:DG00305]
|
Weak (in vivo) |
Rofecoxib
|
Stiripentol
|
Terbinafine [DG:DG00375]
|
Weak (in vivo) |
Tiabendazole
|
Moderate (in vivo) |
Ticlopidine
|
Weak (in vivo) |
Vemurafenib
|
Moderate (in vivo) |
Verapamil [DG:DG00329]
|
Weak (in vivo) |
Viloxazine [DG:DG00956]
|
Zafirlukast
|
Zileuton
|
Moderate (in vivo) |
CYP2A6 [HSA:1548]
|
CYP2B6 [HSA:1555]
|
CYP2C8 [HSA:1558]
|
CYP2C9 [HSA:1559]
|
Amiodarone [DG:DG00204]
|
Moderate (in vivo) |
Benzbromarone
|
Bucolome
|
Capecitabine
|
Weak (in vivo) |
Carmofur
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Choline fenofibrate
|
Cotrimoxazole
|
Weak (in vivo) |
Croconazole
|
Ciclosporin
|
Delavirdine [DG:DG00662]
|
Diosmin
|
Disulfiram
|
Doxifluridine
|
Lovastatin
|
Fenofibrate
|
Etravirine
|
Weak (in vivo) |
Fluconazole [DG:DG00371]
|
Moderate (in vivo) |
Fluorouracil [DG:DG00687]
|
Fluvastatin [DG:DG00354]
|
Weak (in vivo) |
Fluvoxamine [DG:DG00946]
|
Weak (in vivo) |
Isoconazole [DG:DG00365]
|
Isoniazid [DG:DG00642]
|
Lanoconazole
|
Leflunomide
|
Miconazole [DG:DG00004]
|
Moderate (in vivo) |
Metronidazole
|
Weak (in vivo) |
Neticonazole
|
Oxandrolone
|
Moderate (in vivo) |
Oxiconazole [DG:DG00367]
|
Phenylbutazone [DG:DG00745]
|
Probenecid
|
Sertraline [DG:DG00945]
|
Sulconazole [DG:DG00366]
|
Sulfinpyrazone
|
Weak (in vivo) |
Stiripentol
|
Sulfamethoxazole
|
Sulfaphenazole
|
Teniposide
|
Tegafur
|
Tigecycline
|
Tienilic acid
|
Voriconazole
|
Weak (in vivo) |
Zafirlukast
|
Weak (in vivo) |
CYP2C19 [HSA:1557]
|
Allicin
|
Weak (in vivo) |
Armodafinil
|
Weak (in vivo) |
Carbamazepine
|
Weak (in vivo) |
Chloramphenicol [DG:DG00399]
|
Cimetidine [DG:DG00017]
|
Weak (in vivo) |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Clarithromycin [DG:DG00605]
|
Clopidogrel [DG:DG00155]
|
Delavirdine [DG:DG00662]
|
Desvenlafaxine [DG:DG00963]
|
Dexlansoprazole
|
Erythromycin [DG:DG00436]
|
Esomeprazole [DG:DG00023]
|
Moderate (in vivo) |
Etravirine
|
Weak (in vivo) |
Felbamate
|
Weak (in vivo) |
Fluconazole [DG:DG00371]
|
Strong (in vivo) |
Fluoxetine [DG:DG00942]
|
Moderate (in vivo) |
Fluvoxamine [DG:DG00946]
|
Strong (in vivo) |
Grapefruit juice
|
Human growth hormone (rhGH)
|
Weak (in vivo) |
Indometacin [DG:DG00241]
|
Ketoconazole
|
Weak (in vivo) |
Lansoprazole
|
Moclobemide
|
Moderate (in vivo) |
Modafinil
|
Omeprazole
|
Moderate (in vivo) |
Oxcarbazepine
|
Pantoprazole [DG:DG00021]
|
Rabeprazole [DG:DG00022]
|
Ritonavir
|
Roxithromycin
|
Stiripentol
|
Ticlopidine
|
Strong (in vivo) |
Troleandomycin
|
Topiramate
|
Voriconazole
|
Moderate (in vivo) |
CYP2D6 [HSA:1565]
|
Abiraterone
|
Amiodarone [DG:DG00204]
|
Bepridil [DG:DG00333]
|
Bupropion
|
Strong (in vivo) |
Celecoxib
|
Weak (in vivo) |
Chlorphenamine [DG:DG01099]
|
Chlorpromazine [DG:DG00867]
|
Cidoxepin
|
Cimetidine [DG:DG00017]
|
Weak (in vivo) |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Cinacalcet
|
Moderate (in vivo) |
Clemastine [DG:DG00387]
|
Clobazam
|
Clomipramine [DG:DG00929]
|
Cobicistat
|
Cocaine [DG:DG00808]
|
Dacomitinib [DG:DG01793]
|
Desvenlafaxine [DG:DG00963]
|
Weak (in vivo) |
Dexchlorpheniramine [DG:DG01098]
|
Diltiazem [DG:DG00331]
|
Weak (in vivo) |
Diphenhydramine [DG:DG00390]
|
Doxepin [DG:DG00937]
|
Doxorubicin [DG:DG00696]
|
Duloxetine [DG:DG00962]
|
Moderate (in vivo) |
Echinacea
|
Weak (in vivo) |
Escitalopram [DG:DG00947]
|
Weak (in vivo) |
Fluoxetine [DG:DG00942]
|
Strong (in vivo) |
Febuxostat
|
Weak (in vivo) |
Gefitinib
|
Weak (in vivo) |
Halofantrine [DG:DG01021]
|
Hydralazine
|
Weak (in vivo) |
Hydroxychloroquine
|
Weak (in vivo) |
Hydroxyzine [DG:DG00912]
|
Imatinib [DG:DG00710]
|
Weak (in vivo) |
Labetalol [DG:DG00320]
|
Levomepromazine [DG:DG00868]
|
Levomethadone [DG:DG01002]
|
Lopinavir
|
Lorcaserin
|
Methadone [DG:DG00999]
|
Weak (in vivo) |
Metoclopramide [DG:DG00055]
|
Mibefradil [DG:DG00328]
|
Midodrine [DG:DG00224]
|
Mirabegron
|
Moclobemide
|
Paroxetine [DG:DG00944]
|
Strong (in vivo) |
Pazopanib
|
Perphenazine [DG:DG00875]
|
Propafenone [DG:DG00200]
|
Weak (in vivo) |
Quinidine [DG:DG00192]
|
Strong (in vivo) |
Ranitidine [DG:DG00018]
|
Weak (in vivo) |
Ranitidine bismuth citrate
|
Ritonavir
|
Weak (in vivo) |
Sertraline [DG:DG00945]
|
Weak (in vivo) |
Stiripentol
|
Telithromycin
|
Weak (in vivo) |
Terbinafine [DG:DG00375]
|
Moderate (in vivo) |
Thioridazine [DG:DG00882]
|
Tripelennamine [DG:DG00383]
|
Vemurafenib
|
Weak (in vivo) |
Venlafaxine [DG:DG00959]
|
Verapamil [DG:DG00329]
|
Weak (in vivo) |
CYP3A4 [HSA:1576]
|
Amiodarone [DG:DG00204]
|
Anastrozole
|
Aprepitant [DG:DG00066]
|
Chloramphenicol [DG:DG00399]
|
Ciclosporin
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Dabrafenib
|
Darunavir [DG:DG00659]
|
Deferasirox
|
Diltiazem [DG:DG00331]
|
Gestodene
|
Erythromycin [DG:DG00436]
|
Ethinylestradiol
|
Itraconazole
|
Josamycin [DG:DG00604]
|
Miconazole [DG:DG00004]
|
Mifepristone
|
Midecamycin [DG:DG01202]
|
Norfloxacin [DG:DG00620]
|
Saquinavir [DG:DG00653]
|
Stiripentol
|
Troleandomycin
|
Verapamil [DG:DG00329]
|
CYP3A5 [HSA:1577]
|
Aprepitant [DG:DG00066]
|
Chloramphenicol [DG:DG00399]
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Diltiazem [DG:DG00331]
|
Itraconazole
|
Mifepristone
|
Norfloxacin [DG:DG00620]
|
Saquinavir [DG:DG00653]
|
Verapamil [DG:DG00329]
|
CYP3A7 [HSA:1551]
|
Aprepitant [DG:DG00066]
|
Chloramphenicol [DG:DG00399]
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Diltiazem [DG:DG00331]
|
Erythromycin [DG:DG00436]
|
Itraconazole
|
Mifepristone
|
Norfloxacin [DG:DG00620]
|
Saquinavir [DG:DG00653]
|
Verapamil [DG:DG00329]
|
CYP3A [HSA:1576 1577 1551]
|
Almorexant
|
Alprazolam
|
Weak (in vivo) |
Amlodipine [DG:DG00322]
|
Weak (in vivo) |
Amiodarone [DG:DG00204]
|
Weak (in vivo) |
Amprenavir
|
Moderate (in vivo) |
Aprepitant [DG:DG00066]
|
Moderate (in vivo) |
Atazanavir [DG:DG00657]
|
Moderate (in vivo) |
Atorvastatin [DG:DG00355]
|
Weak (in vivo) |
Azithromycin [DG:DG00606]
|
Berberine [DG:DG01773]
|
Bicalutamide
|
Weak (in vivo) |
Boceprevir
|
Strong (in vivo) |
Casopitant
|
Ciclosporin
|
Weak (in vivo) |
Cilostazol
|
Weak (in vivo) |
Cimetidine [DG:DG00017]
|
Weak (in vivo) |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Moderate (in vivo) |
Clarithromycin [DG:DG00605]
|
Strong (in vivo) |
Clotrimazole
|
Crizotinib
|
Conivaptan [DG:DG00276]
|
Strong (in vivo) |
Cobicistat
|
Chlorzoxazone
|
Dihydroergotamine
|
Diltiazem [DG:DG00331]
|
Moderate (in vivo) |
Dronedarone [DG:DG00207]
|
Ergotamine [DG:DG00834]
|
Erythromycin [DG:DG00436]
|
Moderate (in vivo) |
Everolimus
|
Fluconazole [DG:DG00371]
|
Moderate (in vivo) |
Fluoxetine [DG:DG00942]
|
Weak (in vivo) |
Fluvoxamine [DG:DG00946]
|
Weak (in vivo) |
Fosamprenavir [DG:DG00656]
|
Moderate (in vivo) |
Fosaprepitant
|
Gemfibrozil
|
Goldenseal
|
Weak (in vivo) |
Grapefruit juice
|
Strong (in vivo) |
Imatinib [DG:DG00710]
|
Moderate (in vivo) |
Indinavir
|
Strong (in vivo) |
Isoniazid [DG:DG00642]
|
Weak (in vivo) |
Istradefylline
|
Itraconazole
|
Strong (in vivo) |
Ivacaftor
|
Ketoconazole
|
Strong (in vivo) |
Lacidipine
|
Lapatinib [DG:DG00715]
|
Linagliptin
|
Lopinavir/ritonavir
|
Strong (in vivo) |
Lurasidone
|
Maraviroc
|
Mibefradil [DG:DG00328]
|
Strong (in vivo) |
Miconazole [DG:DG00004]
|
Nefazodone
|
Strong (in vivo) |
Nelfinavir [DG:DG00655]
|
Strong (in vivo) |
Nilotinib [DG:DG00716]
|
Weak (in vivo) |
Pazopanib
|
Posaconazole
|
Strong (in vivo) |
Propiverine [DG:DG00479]
|
Ranitidine [DG:DG00018]
|
Ranolazine [DG:DG00247]
|
Weak (in vivo) |
Ritonavir
|
Strong (in vivo) |
Roxithromycin
|
Saquinavir [DG:DG00653]
|
Strong (in vivo) |
Tacrolimus [DG:DG00439]
|
Telaprevir
|
Strong (in vivo) |
Telithromycin
|
Strong (in vivo) |
Ticagrelor
|
Troleandomycin
|
Tofisopam
|
Tolvaptan
|
Valsartan
|
Verapamil [DG:DG00329]
|
Moderate (in vivo) |
Voriconazole
|
Strong (in vivo) |
Zileuton
|
Weak (in vivo) |
CYP17 [HSA:1586]
|
|
|
CYP inducers
|
|
|
CYP substrates
|
CYP1A1 [HSA:1543]
|
CYP1A2 [HSA:1544]
|
Adrenaline - lidocaine
|
Alosetron
|
Sensitive (in vivo) |
Amiodarone [DG:DG00204]
|
Aminophylline
|
Amitriptyline [DG:DG00934]
|
Amoxapine
|
Armodafinil
|
Antipyrine
|
Bortezomib
|
Caffeine
|
Sensitive (in vivo) |
Carvedilol [DG:DG00321]
|
Chlorzoxazone
|
Choline theophyllinate
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Ciprofloxacin [DG:DG00617]
|
Clomipramine [DG:DG00929]
|
Clopidogrel [DG:DG00155]
|
Clozapine
|
Cyclobenzaprine [DG:DG00775]
|
Dantrolene [DG:DG00778]
|
Dexpropranolol
|
Duloxetine [DG:DG00962]
|
Sensitive (in vivo) |
Eltrombopag
|
Enoxacin [DG:DG00619]
|
Erlotinib [DG:DG00711]
|
Estradiol [DG:DG00462]
|
Fluvoxamine [DG:DG00946]
|
Fosamprenavir [DG:DG00656]
|
Haloperidol [DG:DG00885]
|
Imipramine [DG:DG00928]
|
Levobupivacaine
|
Lidocaine [DG:DG00196]
|
Melatonin
|
Sensitive (in vivo) |
Methoxsalen
|
Mexiletine [DG:DG00197]
|
Mianserin [DG:DG00951]
|
Mirtazapine
|
Modafinil
|
Naproxen [DG:DG00455]
|
Naratriptan [DG:DG00837]
|
Nicotine
|
Norfloxacin [DG:DG00620]
|
Olanzapine [DG:DG00898]
|
Ondansetron [DG:DG00060]
|
Palonosetron [DG:DG00064]
|
Paracetamol
|
Phenacetin
|
Pimozide
|
Pirfenidone
|
Propafenone [DG:DG00200]
|
Propranolol [DG:DG00305]
|
Ramelteon
|
Sensitive (in vivo) |
Ramosetron [DG:DG01239]
|
Riluzole
|
Ropinirole [DG:DG00862]
|
Ropivacaine [DG:DG00806]
|
Tacrine
|
Sensitive (in vivo) |
Tamoxifen [DG:DG00734]
|
Theophylline
|
Narrow therapeutic range (in vivo) |
Terbinafine [DG:DG00375]
|
Tizanidine
|
Sensitive (in vivo) / Narrow therapeutic range (in vivo) |
Sarpogrelate
|
Stiripentol
|
Verapamil [DG:DG00329]
|
Warfarin [DG:DG00149]
|
Zileuton
|
Zolmitriptan
|
Zolpidem [DG:DG00922]
|
CYP1B1 [HSA:1545]
|
CYP2A6 [HSA:1548]
|
CYP2B6 [HSA:1555]
|
CYP2C8 [HSA:1558]
|
CYP2C9 [HSA:1559]
|
Amiodarone [DG:DG00204]
|
Ampiroxicam
|
Armodafinil
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Benzbromarone
|
Bepridil [DG:DG00333]
|
Bosentan [DG:DG00266]
|
Candesartan [DG:DG00350]
|
Capecitabine
|
Carvedilol [DG:DG00321]
|
Celecoxib
|
Sensitive (in vivo) |
Cyclophosphamide [DG:DG00675]
|
Dabrafenib
|
Delavirdine [DG:DG00662]
|
Diclofenac [DG:DG00441]
|
Dronabinol
|
Entacapone
|
Etizolam
|
Etravirine
|
Fluconazole [DG:DG00371]
|
Fluoxetine [DG:DG00942]
|
Flurbiprofen
|
Fluvastatin [DG:DG00354]
|
Fosamprenavir [DG:DG00656]
|
Fosphenytoin [DG:DG00847]
|
Glibenclamide
|
Glimepiride
|
Glipizide
|
Hexobarbital
|
Ibuprofen [DG:DG00245]
|
Imatinib [DG:DG00710]
|
Irbesartan
|
Leflunomide
|
Lornoxicam
|
Losartan [DG:DG00348]
|
Losartan and diuretics
|
Mefenamic acid
|
Meloxicam
|
Miconazole [DG:DG00004]
|
Modafinil
|
Mofezolac
|
Montelukast [DG:DG01066]
|
Naproxen [DG:DG00455]
|
Naratriptan [DG:DG00837]
|
Nateglinide
|
Nelfinavir [DG:DG00655]
|
Phenytoin [DG:DG00846]
|
Narrow therapeutic range (in vivo) |
Phenytoin, combinations
|
Piroxicam [DG:DG00752]
|
Pitavastatin [DG:DG01838]
|
Quazepam
|
Rosiglitazone [DG:DG00116]
|
Sarpogrelate
|
Sertraline [DG:DG00945]
|
Sildenafil [DG:DG00484]
|
Simvastatin
|
Sorafenib [DG:DG00713]
|
Suprofen
|
Tamoxifen [DG:DG00734]
|
Terbinafine [DG:DG00375]
|
Tenoxicam
|
Tolbutamide [DG:DG00115]
|
Torasemide [DG:DG00273]
|
Tranilast
|
Trimethadione
|
Valproic acid [DG:DG00849]
|
Valsartan
|
Vardenafil [DG:DG00487]
|
Voriconazole
|
Warfarin [DG:DG00149]
|
Narrow therapeutic range (in vivo) |
Zolpidem [DG:DG00922]
|
CYP2C18 [HSA:1562]
|
CYP2C19 [HSA:1557]
|
CYP2D6 [HSA:1565]
|
Ajmaline
|
Alprenolol [DG:DG00303]
|
Amfetamine [DG:DG00966]
|
Amiodarone [DG:DG00204]
|
Amitriptyline [DG:DG00934]
|
Amoxapine
|
Aprindine
|
Aripiprazole
|
Atenolol
|
Atomoxetine
|
Sensitive (in vivo) |
Bepridil [DG:DG00333]
|
Bopindolol [DG:DG00310]
|
Bunitrolol
|
Carteolol [DG:DG00308]
|
Carvedilol [DG:DG00321]
|
Celecoxib
|
Cevimeline [DG:DG00993]
|
Chlorphenamine [DG:DG01099]
|
Chlorpromazine [DG:DG00867]
|
Cibenzoline [DG:DG00209]
|
Cilnidipine
|
Cilostazol
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Cinnarizine [DG:DG01005]
|
Citalopram [DG:DG00943]
|
Clomipramine [DG:DG00929]
|
Codeine
|
Debrisoquine
|
Delavirdine [DG:DG00662]
|
Desipramine
|
Sensitive (in vivo) |
Dexamfetamine [DG:DG00967]
|
Dexchlorpheniramine [DG:DG01098]
|
Dexfenfluramine [DG:DG00105]
|
Dexpropranolol
|
Dextromethorphan [DG:DG01078]
|
Sensitive (in vivo) |
Dihydrocodeine
|
Diphenhydramine [DG:DG00390]
|
Donepezil [DG:DG00983]
|
Dosulepin
|
Doxepin [DG:DG00937]
|
Duloxetine [DG:DG00962]
|
Encainide [DG:DG00203]
|
Escitalopram [DG:DG00947]
|
Ethanol
|
Fluoxetine [DG:DG00942]
|
Flecainide [DG:DG00201]
|
Flunarizine [DG:DG01006]
|
Fluphenazine
|
Fluvoxamine [DG:DG00946]
|
Fosamprenavir [DG:DG00656]
|
Haloperidol [DG:DG00885]
|
Imatinib [DG:DG00710]
|
Imipramine [DG:DG00928]
|
Leflunomide
|
Levomepromazine [DG:DG00868]
|
Lidocaine [DG:DG00196]
|
Loratadine
|
Maprotiline [DG:DG00941]
|
Mequitazine
|
Metoclopramide [DG:DG00055]
|
Metoprolol
|
Sensitive (in vivo) |
Mexiletine [DG:DG00197]
|
Mianserin [DG:DG00951]
|
Minaprine [DG:DG00954]
|
Mirtazapine
|
Naratriptan [DG:DG00837]
|
Nateglinide
|
Nebivolol
|
Sensitive (in vivo) |
Nelfinavir [DG:DG00655]
|
Nortriptyline [DG:DG00935]
|
Olanzapine [DG:DG00898]
|
Ondansetron [DG:DG00060]
|
Oxycodone
|
Palonosetron [DG:DG00064]
|
Paroxetine [DG:DG00944]
|
Pergolide [DG:DG00861]
|
Perhexiline [DG:DG00334]
|
Perphenazine [DG:DG00875]
|
Sensitive (in vivo) |
Phenacetin
|
Phenformin [DG:DG00112]
|
Pimozide
|
Narrow therapeutic range (in vivo) |
Pindolol
|
Propafenone [DG:DG00200]
|
Promethazine [DG:DG00385]
|
Propranolol [DG:DG00305]
|
Ramosetron [DG:DG01239]
|
Risperidone
|
Sarpogrelate
|
Selegiline [DG:DG00864]
|
Sparteine [DG:DG00195]
|
Tamoxifen [DG:DG00734]
|
Tandospirone
|
Telithromycin
|
Thioridazine [DG:DG00882]
|
Narrow therapeutic range (in vivo) |
Timolol [DG:DG00306]
|
Tolterodine [DG:DG00480]
|
Sensitive (in vivo) |
Tramadol [DG:DG00824]
|
Trazodone [DG:DG00952]
|
Trimipramine [DG:DG00931]
|
Tropisetron [DG:DG00062]
|
Venlafaxine [DG:DG00959]
|
Sensitive (in vivo) |
Zuclopenthixol [DG:DG00896]
|
CYP2J2 [HSA:1573]
|
CYP3A4 [HSA:1576]
|
Adrenaline - lidocaine
|
Alprazolam
|
Amitriptyline [DG:DG00934]
|
Amiodarone [DG:DG00204]
|
Amlodipine [DG:DG00322]
|
Amoxapine
|
Ampiroxicam
|
Amprenavir
|
Anastrozole
|
Apixaban
|
Aprepitant [DG:DG00066]
|
Aprindine
|
Aranidipine
|
Aripiprazole
|
Armodafinil
|
Astemizole
|
Atorvastatin [DG:DG00355]
|
Atorvastatin and amlodipine
|
Axitinib
|
Atazanavir [DG:DG00657]
|
Azelnidipine
|
Barnidipine [DG:DG00325]
|
Benidipine [DG:DG00327]
|
Bepridil [DG:DG00333]
|
Bicalutamide
|
Blonanserin
|
Bosentan [DG:DG00266]
|
Bortezomib
|
Bromazepam
|
Bromocriptine [DG:DG00452]
|
Bromperidol [DG:DG00890]
|
Budesonide
|
Budesonide - formoterol
|
Bupivacaine
|
Cabergoline
|
Caffeine
|
Candesartan cilexetil - amlodipine besilate
|
Carbamazepine
|
Carvedilol [DG:DG00321]
|
Cerivastatin [DG:DG00356]
|
Cevimeline [DG:DG00993]
|
Chloramphenicol [DG:DG00399]
|
Chlorphenamine [DG:DG01099]
|
Cibenzoline [DG:DG00209]
|
Ciclesonide
|
Ciclosporin
|
Cilnidipine
|
Cilostazol
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Cinacalcet
|
Ciprofloxacin [DG:DG00617]
|
Cisapride
|
Citalopram [DG:DG00943]
|
Clarithromycin [DG:DG00605]
|
Clobazam
|
Clomipramine [DG:DG00929]
|
Clopidogrel [DG:DG00155]
|
Clozapine
|
Codeine
|
Colchicine
|
Colforsin daropate
|
Conjugated estrogens [DG:DG00465]
|
Cortisone
|
Cyclophosphamide [DG:DG00675]
|
Dabrafenib
|
Darunavir [DG:DG00659]
|
Delavirdine [DG:DG00662]
|
Dexamethasone [DG:DG00011]
|
Dexchlorpheniramine [DG:DG01098]
|
Dexlansoprazole
|
Dexpropranolol
|
Dextromethorphan [DG:DG01078]
|
Diaphenylsulfone
|
Diazepam
|
Dienogest
|
Diltiazem [DG:DG00331]
|
Disopyramide [DG:DG00194]
|
Docetaxel [DG:DG00694]
|
Domperidone [DG:DG00057]
|
Donepezil [DG:DG00983]
|
Dronabinol
|
Dutasteride
|
Efavirenz
|
Enoxacin [DG:DG00619]
|
Eplerenone
|
Ergometrine [DG:DG00446]
|
Ergotamine [DG:DG00834]
|
Erlotinib [DG:DG00711]
|
Erythromycin [DG:DG00436]
|
Ethylmorphine
|
Escitalopram [DG:DG00947]
|
Esomeprazole [DG:DG00023]
|
Estazolam
|
Ethinylestradiol
|
Etoposide
|
Etravirine
|
Exemestane
|
Estradiol [DG:DG00462]
|
Estrogens, esterified
|
Ethosuximide
|
Etizolam
|
Ethyl loflazepate
|
Felodipine
|
Fentanyl
|
Fentanyl, combinations
|
Flecainide [DG:DG00201]
|
Fluvastatin [DG:DG00354]
|
Fluconazole [DG:DG00371]
|
Finasteride
|
Finasteride
|
Fluvoxamine [DG:DG00946]
|
Fosamprenavir [DG:DG00656]
|
Gefitinib
|
Gemtuzumab
|
Gestodene
|
Haloperidol [DG:DG00885]
|
Halothane
|
Hydrocortisone [DG:DG00012]
|
Hydroquinine
|
Hydroxyzine [DG:DG00912]
|
Ifosfamide
|
Imidafenacin
|
Imipramine [DG:DG00928]
|
Indinavir
|
Irbesartan and amlodipine
|
Isopropylantipyrine - ergotamine tartrate - anhydrous caffeine
|
Imatinib [DG:DG00710]
|
Irinotecan [DG:DG00726]
|
Itraconazole
|
Josamycin [DG:DG00604]
|
Ketoconazole
|
Lansoprazole
|
Lansoprazole, amoxicillin and clarithromycin
|
Lapatinib [DG:DG00715]
|
Leflunomide
|
Lercanidipine [DG:DG00326]
|
Letrozole
|
Levacetylmethadol [DG:DG01000]
|
Levobupivacaine
|
Levomethadone [DG:DG01002]
|
Levonorgestrel and estrogen
|
Lidocaine [DG:DG00196]
|
Lidocaine hydrochloride - epinephrine bitartrate
|
Loratadine
|
Losartan [DG:DG00348]
|
Lovastatin
|
Manidipine
|
Meloxicam
|
Methylergometrine
|
Methylprednisolone
|
Mexiletine [DG:DG00197]
|
Miconazole [DG:DG00004]
|
Mometasone
|
Nateglinide
|
Methadone [DG:DG00999]
|
Methoxyflurane
|
Mexazolam
|
Mianserin [DG:DG00951]
|
Midazolam [DG:DG00920]
|
Mirtazapine
|
Modafinil
|
Montelukast [DG:DG01066]
|
Mosapride
|
Mozavaptane
|
Nalfurafine
|
Nelfinavir [DG:DG00655]
|
Naratriptan [DG:DG00837]
|
Nilotinib [DG:DG00716]
|
Nordazepam
|
Norfloxacin [DG:DG00620]
|
Nicardipine [DG:DG00323]
|
Nifedipine
|
Nilvadipine
|
Nimodipine
|
Nisoldipine
|
Nitrendipine
|
Ofloxacin [DG:DG00616]
|
Olmesartan medoxomil - azelnidipine
|
Omeprazole
|
Ondansetron [DG:DG00060]
|
Oxycodone
|
Paclitaxel
|
Palonosetron [DG:DG00064]
|
Paracetamol
|
Perospirone
|
Pimozide
|
Piroxicam [DG:DG00752]
|
Pranlukast [DG:DG01065]
|
Pravastatin [DG:DG00353]
|
Praziquantel
|
Progesterone
|
Propranolol [DG:DG00305]
|
Propafenone [DG:DG00200]
|
Propiverine [DG:DG00479]
|
Propranolol [DG:DG00305]
|
Quinidine [DG:DG00192]
|
Quinine [DG:DG01019]
|
Quinupristin/dalfopristin
|
Quazepam
|
Quetiapine
|
Rabeprazole [DG:DG00022]
|
Ramelteon
|
Rifabutin
|
Rifampicin [DG:DG00639]
|
Risperidone
|
Ritonavir
|
Rivaroxaban
|
Roxithromycin
|
Salmeterol [DG:DG01051]
|
Salmeterol - fluticasone
|
Saquinavir [DG:DG00653]
|
Sarpogrelate
|
Selegiline [DG:DG00864]
|
Sevoflurane
|
Sertraline [DG:DG00945]
|
Sildenafil [DG:DG00484]
|
Simvastatin
|
Solifenacin
|
Sorafenib [DG:DG00713]
|
Stiripentol
|
Sunitinib
|
Tacrolimus
|
Tadalafil
|
Tamibarotene
|
Tamoxifen [DG:DG00734]
|
Tandospirone
|
Temazepam
|
Telithromycin
|
Telmisartan and amlodipine
|
Temsirolimus
|
Teniposide
|
Terbinafine [DG:DG00375]
|
Terfenadine
|
Testosterone [DG:DG00460]
|
Tofisopam
|
Tolterodine [DG:DG00480]
|
Topiramate
|
Toremifene [DG:DG00735]
|
Tramadol [DG:DG00824]
|
Trazodone [DG:DG00952]
|
Triazolam
|
Trimethadione
|
Troleandomycin
|
Valproic acid [DG:DG00849]
|
Valsartan and amlodipine
|
Verapamil [DG:DG00329]
|
Vinblastine [DG:DG00689]
|
Vincristine [DG:DG00690]
|
Vindesine [DG:DG00691]
|
Vinorelbine [DG:DG00692]
|
Voriconazole
|
Zonisamide
|
Zaleplon
|
Ziprasidone [DG:DG00892]
|
Zolpidem [DG:DG00922]
|
Zopiclone
|
Zotepine
|
CYP3A5 [HSA:1577]
|
CYP3A7 [HSA:1551]
|
CYP3A [HSA:1576 1577 1551]
|
CYP4B1 [HSA:1580]
|
|
|
Transporter inhibitors
|
ABCB1 [HSA:5243]
|
ABCB4 [HSA:5244]
|
ABCB11 [HSA:8647]
|
ABCC1 [HSA:4363]
|
ABCC2 [HSA:1244]
|
ABCC3 [HSA:8714]
|
ABCC4 [HSA:10257]
|
ABCG2 [HSA:9429]
|
SLC15A2 [HSA:6565]
|
SLCO1A2 [HSA:6579]
|
SLCO1B1 [HSA:10599]
|
SLCO1B3 [HSA:28234]
|
SLCO2B1 [HSA:11309]
|
SLC22A1 [HSA:6580]
|
SLC22A2 [HSA:6582]
|
Cetirizine [DG:DG01107]
|
Cimetidine [DG:DG00017]
|
FDA |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Diphenhydramine [DG:DG00390]
|
Famotidine
|
Pilsicainide [DG:DG01257]
|
Quinidine [DG:DG00192]
|
FDA |
Ranitidine [DG:DG00018]
|
Testosterone [DG:DG00460]
|
SLC22A3 [HSA:6581]
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Famotidine
|
Prazosin [DG:DG00253]
|
Verapamil [DG:DG00329]
|
SLC22A8 [HSA:9376]
|
OAT1 [HSA:9356]
|
OAT2 [HSA:10864]
|
OAT3 [HSA:9376]
|
Benzylpenicillin [DG:DG00534]
|
Cimetidine [DG:DG00017]
|
FDA |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Diclofenac [DG:DG00441]
|
FDA |
Probenecid
|
FDA |
URAT1 [HSA:116085]
|
MATE1 [HSA:55244]
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Procainamide [DG:DG00193]
|
Pyrimethamine
|
Quinidine [DG:DG00192]
|
MATE2 [HSA:146802]
|
Cimetidine [DG:DG00017]
|
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Pramipexole [DG:DG00863]
|
Pyrimethamine
|
Quinidine [DG:DG00192]
|
|
|
Transporter inducers
|
|
|
Transporter substrates
|
ABCB1 [HSA:5243]
|
ABCB4 [HSA:5244]
|
ABCB11 [HSA:8647]
|
ABCC2 [HSA:1244]
|
ABCC3 [HSA:8714]
|
ABCC4 [HSA:10257]
|
ABCG2 [HSA:9429]
|
OAT1 [HSA:9356]
|
OAT2 [HSA:10864]
|
OAT3 [HSA:9376]
|
SLC15A1 [HSA:6564]
|
SCL15A2 [HSA:6565]
|
SLCO1A2 [HSA:6579]
|
SLCO1B1 [HSA:10599]
|
SLCO1B3 [HSA:28234]
|
SLCO2B1 [HSA:11309]
|
SLC22A1 [HSA:6580]
|
SLC22A2 [HSA:6582]
|
Amantadine [DG:DG00860]
|
FDA |
Amiloride [DG:DG00275]
|
FDA |
Cetirizine [DG:DG01107]
|
Cimetidine [DG:DG00017]
|
FDA |
D00295 Cimetidine (JP17/USP/INN)
D03503 Cimetidine hydrochloride (USP)
|
|
Cisplatin
|
Creatinine
|
Dopamine [DG:DG00213]
|
FDA |
Famotidine
|
FDA |
Memantine [DG:DG00986]
|
FDA |
Metformin [DG:DG00113]
|
FDA |
Nafamostat
|
Oxaliplatin
|
Pindolol
|
Pramipexole [DG:DG00863]
|
Procainamide [DG:DG00193]
|
FDA |
Ranitidine [DG:DG00018]
|
FDA |
Varenicline [DG:DG00995]
|
FDA |
Ranitidine [DG:DG00018]
|
Quinine [DG:DG01019]
|
Varenicline [DG:DG00995]
|
SLC22A3 [HSA:6581]
|
SLC28A2 [HSA:9153]
|
SLC28A3 [HSA:64078]
|
SLC29A1 [HSA:2030]
|
SLC29A2 [HSA:3177]
|
MATE1 [HSA:55244]
|
MATE2 [HSA:146802]
|
Drug interactions with metabolizing enzymes and transporters