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Name |
Description |
Object |
Legend |
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hsa05322
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Systemic lupus erythematosus |
...macrophage activation. Activation of complement (C5) leads to injury both through formation of the m... |
...H) 102723407 (IGH) 1991 (ELANE) 1511 (CTSG) 727 (C5) 720 (C4A), 721 (C4B) 718 (C3) 717 (C2) 716 (C1S... |
...l tolerance Autoantibodies Chemotaxis Neutrophil C5b C5a Membrane attack complex Defective clearance... |
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hsa00900
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Terpenoid backbone biosynthesis |
...lass of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the... |
C05859 (ditrans,polycis-Polyprenyl diphosphate) C06081 (Polyprenol) C00022 (Pyruvate) C00024 (Acetyl... |
MEP/DOXP pathway Mevalonate pathway Dehydro dolichol-PP ditrans,polycis-Polyprenol Glycolysis TERPEN... |
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hsa05130
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Pathogenic Escherichia coli infection |
Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic ... |
...(TUBB2A), 81027 (TUBB1), 84617 (TUBB6) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
Golgi Regulation of actin cytoskeleton Flagellar assembly Tight junction Toll-like receptor signalin... |
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hsa01100
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Metabolic pathways |
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...) C01100 (L-Histidinol phosphate) G13124 G13123 (C50-P-P-GlcNAc-Rha-linked galactan polymer) G13122 ... |
...s Glucosinolate biosynthesis Lysine biosynthesis C5-Branched dibasic acid metabolism Nitrotoluene de... |
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hsa04141
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Protein processing in endoplasmic reticulum |
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of... |
...E2D2), 7323 (UBE2D3) 10294 (DNAJA2), 285126 (DNAJC5G), 3300 (DNAJB2), 3301 (DNAJA1), 3337 (DNAJB1), ... |
...otein folding enzymes dislocon channel VIP36 ERGIC53 Lectin associated Folding intermediate N-glyco... |
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hsa04360
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Axon guidance |
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a var... |
...1) 25791 (NGEF) 5921 (RASA1) 25 (ABL1) 137970 (UNC5D), 219699 (UNC5B), 8633 (UNC5C), 90249 (UNC5A) 7... |
Par6 Par3 CXCR4 ERK Rac Rac Rac DCC NFAT CaN Netrin-G1 Netrin-4 Slit3 Slit2 Slit1 FAK Cdc42 ROCK PAK... |
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hsa05135
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Yersinia infection |
Pathogenic Yersinia injects virulent Yersinia outer proteins (Yops) into the host cell through a typ... |
...e) 3688 (ITGB1) 6714 (SRC) 8976 (WASL) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
ITGB1 Src N-WASP Arp2/3 Fibronectin p130Cas Crk DOCK180 PIP(5)KIα Actin PI(4,5)P PIP -binding protei... |
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hsa04613
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Neutrophil extracellular trap formation |
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action... |
... 2244 (FGB), 2266 (FGG) 10013 (HDAC6), 10014 (HDAC5), 3065 (HDAC1), 3066 (HDAC2), 51564 (HDAC7), 558... |
...hromatin Vesicles filled with NETs MPO LL37 iC3b C5aR CR1 C3b C5a Opsonised pathogen Activated plate... |
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hsa04144
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Endocytosis |
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins... |
...WASHC2A) 51019 (WASHC3) 23325 (WASHC4) 9897 (WASHC5) 829 (CAPZA1), 830 (CAPZA2), 93661 (CAPZA3) 2311... |
...MP7 Arf Arf GDP GTP protrudin KIF5 WASH FAM21 CCDC53 SWIP Strump CAPZA Spartin CAPZB Rab35 Rab10 Snx... |
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hsa04810
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Regulation of actin cytoskeleton |
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...2147 (F2) 7114 (TMSB4X), 9087 (TMSB4Y) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
...in MyosinII F-Actin Arp2/3 CXCR4 LPAR CXCL12 LPA C5b-9 AKT1 RGC32 |
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hsa04976
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Bile secretion |
Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins i... |
... 10257 (ABCC4) 5244 (ABCB4) 5243 (ABCB1) 6523 (SLC5A1) 6513 (SLC2A1) 343 (AQP8) 6548 (SLC9A1) 8431 (... |
AQP9 BILE SECRETION Tight junction Hepatocyte NHE1 HCO Cholangiocyte AE2 ATP CFTR HCO cAMP NBC1 2HC... |
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hsa05171
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Coronavirus disease - COVID-19 |
Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused b... |
...(TNF) 3627 (CXCL10) 1437 (CSF2) 1440 (CSF3) 728 (C5AR1) 719 (C3AR1) 2212 (FCGR2A) 1536 (CYBB) 102723... |
...k1 IL-1β IL-2 IL-8 MCP-1 TNFα IP-10 GM-CSF G-CSF C5AR1 Acute lung injury (ALI) Tissue injury C3AR1 S... |
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hsa00100
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Steroid biosynthesis |
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...-8,24-dien-3beta-ol) C22136 (Zymosterone) 6309 (SC5D) 10682 (EBP) 1717 (DHCR7) 6309 (SC5D) 10682 (EB... |
STE1 5.3.3.5 1.3.1.21 1.14.19.20 5.3.3.5 ERG4 ERG5 ERG3 ERG2 Brassinosteroid biosynthesis Calcitriol... |
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hsa04530
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Tight junction |
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion th... |
...90 (TUBA1C) 123720 (WHAMM), 7454 (WAS) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
PAR6 PATJ Cdc42 TIGHT JUNCTION Inside Paracellular space LKB1 Cingulin Tiam1 Decreased paracellul... |
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hsa04740
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Olfactory transduction |
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity tr... |
...14), 135946 (OR6B1), 135948 (OR2F2), 138799 (OR13C5), 138802 (OR13C8), 138803 (OR13C3), 138804 (OR13... |
OLFACTORY TRANSDUCTION cAMP Golf ACⅢ CNG CaCC Olfactory receptor neuron (ORN) Depolarization ODOR ... |
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hsa05100
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Bacterial invasion of epithelial cells |
Many pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellu... |
...059 (HCLS1) 3678 (ITGA5), 3688 (ITGB1) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
BACTERIAL INVASION OF EPITHELIAL CELLS ECM-receptor interaction Regulation of actin cytoskel... |
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hsa05131
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Shigellosis |
Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enter... |
...98 (CDC42) 10163 (WASF2), 8936 (WASF1) 10092 (ARPC5), 10093 (ARPC4), 10094 (ARPC3), 10095 (ARPC1B), ... |
SHIGELLOSIS Shigella dysenteria Shigella flexneri Shigella boydii Shigella sonnei TNF-R1 TNFα IκBα I... |
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hsa04610
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Complement and coagulation cascades |
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a ... |
...nt 2a), C22533 (Complement component 3b) C16510 (C5a anaphylatoxin) C22545 (Complement component 5b)... |
...Cell lysis C6/7/8/9 CD59 Clusterin Vitronectin (C5 convertase) (C5 convertase) C3bBb3b C4b2a3b C5a ... |
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hsa04080
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Neuroactive ligand-receptor interaction |
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...), 4158 (MC2R), 4159 (MC3R), 4160 (MC4R), 4161 (MC5R) 2693 (GHSR) 1909 (EDNRA), 1910 (EDNRB) 886 (CC... |
...SSTR OPR NTSR NPYR MCR GHSR EDNR CCKR APLNR FPRL C5R C3AR BDKRB GRPR AGTR TAR HTR HRH DRD ADR Lipoxi... |
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hsa04657
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IL-17 signaling pathway |
The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles... |
...CCL20) 100289462 (DEFB4B), 1673 (DEFB4A) 4586 (MUC5AC), 727897 (MUC5B) 4318 (MMP9) 4322 (MMP13) 3565... |
...tor IL-17D DNA CXCL1 CCL2 CCL7 CCL20 defensin MUC5 MMP9 MMP13 IL-4 IL-5 IL-13 TARC Th17 cell differ... |