| Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
|
hsa05207
|
|
Chemical carcinogenesis - receptor activation |
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stage... |
...S), 3845 (KRAS), 4893 (NRAS) 5894 (RAF1) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 209... |
CHEMICAL CARCINOGENESIS - RECEPTOR ACTIVATION EGFR DNA Ras Raf MEK ERK1/2 DNA PKA pCREB MAPK sig... |
|
hsa05224
|
|
Breast cancer |
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breas... |
...RAS) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 257... |
BREAST CANCER EGFR CoR Ras Raf MEK ERK1/2 Shc Grb2 SOS Estrogen signaling pathway Jagged Notch mTOR... |
|
hsa05235
|
|
PD-L1 expression and PD-1 checkpoint pathway in cancer |
Programmed cell death 1 (PD1) and its ligand (PDL1) are key regulatory physiological immune checkpoi... |
...5777 (PTPN6), 5781 (PTPN11) 5133 (PDCD1) 5604 (MAP2K1), 5605 (MAP2K2) 5894 (RAF1) 5594 (MAPK1), 5595... |
PIP IκB NFκB IKK AKT PI3K RasGRP1 Ras AP1 NFAT CaN PLC-γ1 ZAP70 CD3ε CD3δ TCRβ TCRα CD3ζ CD3ζ CD3γ C... |
|
hsa04550
|
|
Signaling pathways regulating pluripotency of stem cells |
Pluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the poten... |
...S), 3845 (KRAS), 4893 (NRAS) 5894 (RAF1) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 529... |
Wnt APC Axin Dvl Frizzled SIGNALING PATHWAYS REGULATING PLURIPOTENCY OF STEM CELLS β-catenin G... |
|
hsa04915
|
|
Estrogen signaling pathway |
Estrogens are steroid hormones that regulate a plethora of physiological processes in mammals, inclu... |
...S), 3845 (KRAS), 4893 (NRAS) 5894 (RAF1) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 104... |
ESTROGEN SIGNALING PATHWAY GPER c-Src MMP HB-EGF EGFR HB-EGF DNA DNA cAMP PKA Ras Raf MEK ERK1/2 p... |
|
hsa04926
|
|
Relaxin signaling pathway |
Human relaxin-2 ("relaxin"), originally identified as a peptidic hormone of pregnancy, is now known ... |
...S), 3845 (KRAS), 4893 (NRAS) 5894 (RAF1) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 232... |
PIP AKT RELAXIN SIGNALING PATHWAY RXFP1 IκB NF κB NFκB signaling pathway eNOS Vasodilation VEGF si... |
|
hsa05034
|
|
Alcoholism |
Alcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is pro... |
...RAS) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1) 5594 (MAPK1), 5595 (MAPK3) 2354 (FOSB) 8520 (... |
ALCOHOLISM Neuron (Presynaptic terminal) Neuron (Postsynaptic cell) VMAT Control Dopaminergic synaps... |
|
hsa05161
|
|
Hepatitis B |
Hepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circu... |
...KCG) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 235... |
Mitochondria VDAC3 CytC CASP9 Apaf-1 CASP12 CASP3 Apoptosis Bax Survivin Ca release PKC Raf MEK E... |
|
hsa05210
|
|
Colorectal cancer |
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. C... |
...MYC) 595 (CCND1) 10297 (APC2), 324 (APC) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 372... |
DCC CASP3 TGFβ PI3K CASP9 APPL CASP3 APC Smad2 TGFβRI Smad4 hMLH1 hMSH2 K-Ras Raf JNK Axin Axin RalG... |
|
hsa05214
|
|
Glioma |
Gliomas are the most common of the primary brain tumors and account for more than 40% of all central... |
...OS2) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 529... |
EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR EGF TGFα PDGF IGF-1 EGFR PDGFR IGFR CAM CAMK PKC Shc Grb2 Sos Ra... |
|
hsa05216
|
|
Thyroid cancer |
Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine ca... |
...F) 673 (BRAF) 5594 (MAPK1), 5595 (MAPK3) 5604 (MAP2K1), 5605 (MAP2K2) 5468 (PPARG), 7849 (PAX8) 6256... |
Ras PPARγ BRAF BRAF ERK MEK PPFP RXR β-catenin c-Myc ECAD THYROID CANCER ERK CyclinD1 MEK BRAF Ras ... |
|
hsa05225
|
|
Hepatocellular carcinoma |
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neo... |
...RAS) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 257... |
HEPATOCELLULAR CARCINOMA EGFR Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K IGF-II IGF1R PI3K-Akt signal... |
|
hsa05226
|
|
Gastric cancer |
Gastric cancer (GC) is one of the world's most common cancers. According to Lauren's histological cl... |
...RAS) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 257... |
GASTRIC CANCER Ras Raf MEK ERK1/2 Shc Grb2 SOS mTOR S6K PI3K-Akt signaling pathway Ras Raf MEK ERK1... |
|
hsa01521
|
|
EGFR tyrosine kinase inhibitor resistance |
EGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also ser... |
...R) 1950 (EGF) 5594 (MAPK1), 5595 (MAPK3) 5604 (MAP2K1), 5605 (MAP2K2) 369 (ARAF), 5894 (RAF1), 673 (... |
Non-small cell lung cancer Her3 Her2 EGFR Pancreatic cancer mTOR signaling pathway GSK-3 eI... |
|
hsa01522
|
|
Endocrine resistance |
Endocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast canc... |
...RAS) 369 (ARAF), 5894 (RAF1), 673 (BRAF) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 285... |
ENDOCRINE RESISTANCE GPR30 Src MMP HB-EGF EGFR HB-EGF CoA DNA DNA cAMP PKA Ras Raf MEK ERK1/2 GPR30... |
|
hsa04010
|
|
MAPK signaling pathway |
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in... |
...595 (MAPK3) 8649 (LAMTOR3) 5605 (MAP2K2) 5604 (MAP2K1) 5894 (RAF1) 673 (BRAF) 5921 (RASA1) 4763 (NF1... |
LPS RasGRF MKP PTP PP2CB FASL DAG cAMP HGK cPLA2 STMN1 Tau NFκB IKK NIK ERK MP1 MEK2 MEK1 Raf1 RafB ... |
|
hsa04012
|
|
ErbB signaling pathway |
The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor l... |
...G) 1950 (EGF) 5594 (MAPK1), 5595 (MAPK3) 5604 (MAP2K1), 5605 (MAP2K2) 369 (ARAF), 5894 (RAF1), 673 (... |
Non-small cell lung cancer Grb2 Elk ErbB-4 ErbB-4 ErbB-3 ErbB-3 STAT5 ErbB-2 ErbB-2 ErbB-2 ErbB-2... |
|
hsa04014
|
|
Ras signaling pathway |
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating c... |
...'-Cyclic AMP) 5594 (MAPK1), 5595 (MAPK3) 5604 (MAP2K1), 5605 (MAP2K2) 5894 (RAF1) 22800 (RRAS2), 228... |
MAPK signaling pathway RAS SIGNALING PATHWAY ERK MEK Raf-1 Ras PI3K-Akt signaling pathway Grb2 SOS... |
|
hsa04015
|
|
Rap1 signaling pathway |
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction fo... |
...lcium cation) 5594 (MAPK1), 5595 (MAPK3) 5604 (MAP2K1), 5605 (MAP2K2) 5894 (RAF1) 5906 (RAP1A), 5908... |
MAPK signaling pathway RAP1 SIGNALING PATHWAY ERK MEK Raf-1 Rap1 RIAM RTK RalGDS Rac RapL MEK3,6 p... |
|
hsa04022
|
|
cGMP-PKG signaling pathway |
Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO... |
...2A3) 5350 (PLN) 3764 (KCNJ8) 5894 (RAF1) 5604 (MAP2K1), 5605 (MAP2K2) 5594 (MAPK1), 5595 (MAPK3) 572... |
cGMP-PKG SIGNALING PATHWAY MLCP MLC NPR-A cGMP PKG s-GC Sarcoplasmic reticulum (SR) Kca NPR-B Myosi... |