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Thumbnail Image |
Name |
Description |
Object |
Legend |
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hsa04916
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Melanogenesis |
...binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimu... |
...(DVL3) 1638 (DCT) 7306 (TYRP1) 7299 (TYR) 4286 (MITF) 1638 (DCT) 7306 (TYRP1) 7299 (TYR) 5566 (PRKAC... |
Dvl DCT TYRP1 TYR MITF DCT TYRP1 TYR PKA CAMK CAM Gi/o ETB-R c-Kit MITF Melanin Tyrosine SCF Frizzle... |
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hsa05218
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Melanoma |
...53 (p14ARF/HMD2/p53) tumor suppressor pathways. MITF and TP53 are implicated in further melanoma pro... |
...CDH1) 4893 (NRAS) 1019 (CDK4) 595 (CCND1) 4286 (MITF) 5728 (PTEN) 1956 (EGFR), 2260 (FGFR1), 3480 (I... |
... BRAF ECAD Adherens junction NRAS CDK4 CyclinD1 MITF PTEN RTK Bad p14 ARF p21 PIP MDM2 p53 E2F CDK4 ... |
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hsa04137
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Mitophagy - animal |
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to gro... |
...285973 (ATG9B), 79065 (ATG9A) 7942 (TFEB) 4286 (MITF) 7030 (TFE3) 55626 (AMBRA1) 441925 (BECN2), 867... |
...somal degradation USP30 USP15 LC3 LC3 ATG9 TFEB MITF TFE3 DNA Lysosome biogenesis Autophagy AMBRA1 F... |
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hsa04380
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Osteoclast differentiation |
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage... |
...CP5) 799 (CALCR) 3690 (ITGB3) 6688 (SPI1) 4286 (MITF) 7124 (TNF) 7132 (TNFRSF1A) 4773 (NFATC2) 8651 ... |
...V CREB c-Fos DNA CTSK TRAP CTR β3 integrin PU.1 MITF Osteoclast-specific genes Bone marrow-derived m... |
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hsa05200
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Pathways in cancer |
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...EBPA) 861 (RUNX1) 7157 (TP53) 4193 (MDM2) 4286 (MITF) 4609 (MYC) 4149 (MAX) 7709 (ZBTB17) 595 (CCND1... |
... AML1-ETO PU.1 PU.1 C/EBPα C/EBPα AML1 p53 MDM2 MITF c-Myc Max Miz1 CyclinD p21 CDK4/6 E2F CDK2 Cycl... |
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hsa05202
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Transcriptional misregulation in cancer |
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged ... |
...AK1) 1643 (DDB2) 51426 (POLK) 894 (CCND2) 4286 (MITF) |
...nomic instability Increased survival DNA CCND2 MITF Survival, proliferation (TF) |