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Items : 1 - 9 of 9

Entry Thumbnail Image Name Description Object Legend
hsa03050 Proteasome The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such... 3458 (IFNG) 5709 (PSMD3) 5718 (PSMD12) 5717 (PSMD11) 9861 (PSMD6) 5713 (PSMD7) 5719 (PSMD13) 10213 (... IFNγ Rpn1 Rpn2 Rpn10 Rpn11 Lid Base 20S Core Particle Regulatory Particle 19S 26S proteasome (PA700)...
hsa05010 Alzheimer disease Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 sAPP...
hsa05012 Parkinson disease Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae...
hsa05014 Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell...
hsa05016 Huntington disease Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN...
hsa05017 Spinocerebellar ataxia The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk...
hsa05020 Prion disease Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... PrP PRION DISEASE DNA Endoplasmic reticulum (ER) Neuron Endocytosis Proteasome Golgi Early endosome...
hsa05022 Pathways of neurodegeneration - multiple diseases Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... ...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP...
hsa05169 Epstein-Barr virus infection Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... ...710 (PSMD4), 5713 (PSMD7), 5714 (PSMD8), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... gp350 gH/gL gp42 CD21 MHC-II EBNA2 EPSTEIN-BARR VIRUS INFECTION B cell RBP-Jκ SKIP SMRT EBNA3C Vir...

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