Entry |
Thumbnail Image |
Name |
Description |
Object |
Legend |
hsa03050
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Proteasome |
The proteasome is a protein-destroying apparatus involved in many essential cellular functions, such... |
3458 (IFNG) 5709 (PSMD3) 5718 (PSMD12) 5717 (PSMD11) 9861 (PSMD6) 5713 (PSMD7) 5719 (PSMD13) 10213 (... |
IFNγ Rpn1 Rpn2 Rpn10 Rpn11 Lid Base 20S Core Particle Regulatory Particle 19S 26S proteasome (PA700)... |
hsa05010
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Alzheimer disease |
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cogniti... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
PEN2 PSEN NCSTN APH-1 γ-Secretase BACE ADAM10/17 β-Secretase α-Secretase TNF Microglia AICD C99 sAPP... |
hsa05012
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Parkinson disease |
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily f... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
LRRK2 Ubiquitin mediated proteolysis Proteasome Apoptosis UBA1 UbcH7/8 Parkin CDCrel1 synphilin1 Pae... |
hsa05014
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Amyotrophic lateral sclerosis |
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive d... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
SOD1 EAAT2 AMYOTROPHIC LATERAL SCLEROSIS Motor neuron Astrocyte Presynaptic neuron Microglial cell... |
hsa05016
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Huntington disease |
Huntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects m... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
HUNTINGTON DISEASE Cx I Cx II Cx III Cx IV Cx V Htt Htt Htt Htt Htt REST REST coREST Sin3A HDACs DN... |
hsa05017
|
|
Spinocerebellar ataxia |
The autosomal dominant spinocerebellar ataxias (SCAs) are a group of progressive neurodegenerative d... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
Parallel fiber PLC PKC DAG AMPAR mGluR1 Glutamate SPINOCEREBELLAR ATAXIA Glutamatergic synapse Purk... |
hsa05020
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Prion disease |
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal n... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
PrP PRION DISEASE DNA Endoplasmic reticulum (ER) Neuron Endocytosis Proteasome Golgi Early endosome... |
hsa05022
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Pathways of neurodegeneration - multiple diseases |
Neurodegeneration is generally defined as progressive, irreversible loss of neurons, which may affec... |
...713 (PSMD7), 5714 (PSMD8), 5715 (PSMD9), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
PATHWAYS OF NEURODEGENERATION - MULTIPLE DISEASES Endoplasmic reticulum (ER) PrP ER stress CASP... |
hsa05169
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Epstein-Barr virus infection |
Epstein-Barr virus (EBV) is a gamma-herpes virus that widely infects human populations predominantly... |
...710 (PSMD4), 5713 (PSMD7), 5714 (PSMD8), 5717 (PSMD11), 5718 (PSMD12), 5719 (PSMD13), 7979 (SEM1), 9... |
gp350 gH/gL gp42 CD21 MHC-II EBNA2 EPSTEIN-BARR VIRUS INFECTION B cell RBP-Jκ SKIP SMRT EBNA3C Vir... |