Entry |
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Name |
Description |
Object |
Legend |
hsa04066
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HIF-1 signaling pathway |
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... |
...(TF) 7037 (TFRC) 2321 (FLT1) 1950 (EGF) 5054 (SERPINE1) 284 (ANGPT1), 285 (ANGPT2), 51378 (ANGPT4) 7... |
CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mTOR... |
hsa04115
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p53 signaling pathway |
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... |
... 7057 (THBS1) 3486 (IGFBP3) 3479 (IGF1) 5054 (SERPINE1) 575 (ADGRB1) 1029 (CDKN2A) 1026 (CDKN1A) 643... |
Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS... |
hsa04218
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Cellular senescence |
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... |
...6 (TGFBR1), 7048 (TGFBR2) 3486 (IGFBP3) 5054 (SERPINE1) 3805 (KIR2DL4) 3105 (HLA-A), 3106 (HLA-B), 3... |
CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB... |
hsa04371
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Apelin signaling pathway |
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally d... |
...71 (PRKAG1) 56848 (SPHK2), 8877 (SPHK1) 5054 (SERPINE1) 10681 (GNB5), 2770 (GNAI1), 2771 (GNAI2), 27... |
APELIN SIGNALING PATHWAY APJ AMPK Sphk1 PAI-1 PI3K Akt MEK1/2 ERK1/2 P70S6K PLCβ IP3 IP3R RyR mTOR... |
hsa04390
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Hippo signaling pathway |
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies... |
... 4089 (SMAD4) 4089 (SMAD4) 4092 (SMAD7) 5054 (SERPINE1) 1490 (CCN2) 51384 (WNT16), 54361 (WNT4), 747... |
HIPPO SIGNALING PATHWAY KIBRA Mer FRMD SAV1 Mst1/2 YAP/TAZ Lats1/2 Crb α-Catenin RASSF1A CTGF Bir... |
hsa04610
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Complement and coagulation cascades |
The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a ... |
... 1361 (CPB2) 2151 (F2RL2), 9002 (F2RL3) 5054 (SERPINE1), 5055 (SERPINB2), 5104 (SERPINA5), 5270 (SER... |
COMPLEMENT AND COAGULATION CASCADES Plasmin Coagulation cascade Extrinsic pathway Tissue damage F... |
hsa04933
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AGE-RAGE signaling pathway in diabetic complications |
Advanced glycation end products (AGEs) are a complex group of compounds produced through the non-enz... |
... 7423 (VEGFB), 7424 (VEGFC) 6347 (CCL2) 5054 (SERPINE1) 4313 (MMP2) 177 (AGER) 6401 (SELE) 1277 (COL... |
AGE-RAGE SIGNALING PATHWAY IN DIABETIC COMPLICATIONS High glucose Aging Inflammation Oxidative... |
hsa05142
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Chagas disease |
Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease, also called Ame... |
...046 (TGFBR1) 7048 (TGFBR2) 4087 (SMAD2) 5054 (SERPINE1) 2770 (GNAI1), 2771 (GNAI2), 2773 (GNAI3), 27... |
TLR2 TLR4 IFNγ gp160 TcCRT C3b C1q Complement pathway Toll-like receptor signaling pathway TLR9 ... |