Pathway Text Search

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Entry Thumbnail Image Name Description Object Legend
hsa04066 HIF-1 signaling pathway Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of... ...(TF) 7037 (TFRC) 2321 (FLT1) 1950 (EGF) 5054 (SERPINE1) 284 (ANGPT1), 285 (ANGPT2), 51378 (ANGPT4) 7... CUL2 Rbx1 ElonginB ElonginC VEGF PHD VHL HIF-1β p300/CBP HIF-1α Glut1 HIF-1 SIGNALING PATHWAY mTOR...
hsa04115 p53 signaling pathway p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and ... ... 7057 (THBS1) 3486 (IGFBP3) 3479 (IGF1) 5054 (SERPINE1) 575 (ADGRB1) 1029 (CDKN2A) 1026 (CDKN1A) 643... Siah-1 IGF-BP3 Gadd45 MDM-X CHK1 ATR CHK2 ATM Reprimo 14-3-3-σ CDK2 Cyclin E Cell cycle Apoptosis TS...
hsa04218 Cellular senescence Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of f... ...6 (TGFBR1), 7048 (TGFBR2) 3486 (IGFBP3) 5054 (SERPINE1) 3805 (KIR2DL4) 3105 (HLA-A), 3106 (HLA-B), 3... CELLULAR SENESCENCE NORE1A PP1A C-Myc HIPK2 ARF MDM2 p53 P53 signaling pathway PI3K AKT TSC1/2 RHEB...
hsa04371 Apelin signaling pathway Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally d... ...71 (PRKAG1) 56848 (SPHK2), 8877 (SPHK1) 5054 (SERPINE1) 10681 (GNB5), 2770 (GNAI1), 2771 (GNAI2), 27... APELIN SIGNALING PATHWAY APJ AMPK Sphk1 PAI-1 PI3K Akt MEK1/2 ERK1/2 P70S6K PLCβ IP3 IP3R RyR mTOR...
hsa04390 Hippo signaling pathway Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies... ... 4089 (SMAD4) 4089 (SMAD4) 4092 (SMAD7) 5054 (SERPINE1) 1490 (CCN2) 51384 (WNT16), 54361 (WNT4), 747... HIPPO SIGNALING PATHWAY KIBRA Mer FRMD SAV1 Mst1/2 YAP/TAZ Lats1/2 Crb α-Catenin RASSF1A CTGF Bir...
hsa04610 Complement and coagulation cascades The complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a ... ... 1361 (CPB2) 2151 (F2RL2), 9002 (F2RL3) 5054 (SERPINE1), 5055 (SERPINB2), 5104 (SERPINA5), 5270 (SER... COMPLEMENT AND COAGULATION CASCADES Plasmin Coagulation cascade Extrinsic pathway Tissue damage F...
hsa04933 AGE-RAGE signaling pathway in diabetic complications Advanced glycation end products (AGEs) are a complex group of compounds produced through the non-enz... ... 7423 (VEGFB), 7424 (VEGFC) 6347 (CCL2) 5054 (SERPINE1) 4313 (MMP2) 177 (AGER) 6401 (SELE) 1277 (COL... AGE-RAGE SIGNALING PATHWAY IN DIABETIC COMPLICATIONS High glucose Aging Inflammation Oxidative...
hsa05142 Chagas disease Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease, also called Ame... ...046 (TGFBR1) 7048 (TGFBR2) 4087 (SMAD2) 5054 (SERPINE1) 2770 (GNAI1), 2771 (GNAI2), 2773 (GNAI3), 27... TLR2 TLR4 IFNγ gp160 TcCRT C3b C1q Complement pathway Toll-like receptor signaling pathway TLR9 ...

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