KEGG image  Enzymes of 2-oxocarboxylic acid metabolism

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2-Oxoacid chain elongation

MT OT RM Module Pathway Synthase
2.3.3
Hydratase
4.2.1
Dehydrogenase
1.1.1
MT OT RM001 M00010 oxaloacetate => 2-oxoglutarate K01647
CS, gltA
K01681
ACO, acnA
K01682
acnB
K00031
IDH1, icd
K00030
IDH3
OT RM001 M00433 2-oxoglutarate => 2-oxoadipate (yeast) K01655
LYS21
K17450
ACO2
K01705
LYS4
K05824
LYS12
OT RM001 M00433 2-oxoglutarate => 2-oxoadipate (bacteria) K01655
LYS21
K16792
aksD
K16793
aksE
K05824
LYS12
OT RM001 M00608 2-oxoglutarate => 2-oxoadipate (archaea)
2-oxoadipate => 2-oxopimelate
2-oxopimelate => 2-oxosuberate
K10977
aksA
K16792
aksD
K16793
aksE
K10978
aksF
OT RM001 M00535 pyruvate => 2-oxobutanoate K09011
cimA
K01703
leuC
K01704
leuD
K00052
leuB
OT RM001 M00432 2-oxoisovalerate => 2-oxoisocaproate K01649
leuA
K01703
leuC
K01704
leuD
K00052
leuB
K01702
LEU1

Reaction module

RM001 2-Oxocarboxylic acid chain extension by tricarboxylic acid pathway
2.3.3
RC00067
4.2.1
RC00497
1.1.1
RC00114
C00161
2-oxocarboxylic acid (n)
+ C00024
acetyl-CoA
C00161a C00161b C00161c
2-oxocarboxylic acid (n+1)


2-Oxoacid oxidizing enzymes

OT Module Enzyme EC E1 E2 E3 Acceptor
OT M00307 pyruvate dehydrogenase
(acetyl-transferring)
1.2.4.1/2.3.1.12/
1.8.1.4 (1.2.1.51)
K00161
pdhA
K00162
pdhB
K00627
pdhC
K00382
lpd
NAD(P)+
K00163
aceE
M00011 2-oxoglutarate dehydrogenase
(succinyl-transferring)
1.2.4.2/2.3.1.61/
1.8.1.4 (1.2.1.52)
K00164
sucA
K00658
sucB
NAD(P)+
M00036 2-oxoisovalerate dehydrogenase
(2-methylpropanoyl-transferring)
1.2.4.4/2.3.1.168/
1.8.1.4 (1.2.1.25)
K00166
bkdA1
K00167
bkdA2
K09699
bkdB
NAD+
K11381
bkdA

OT Module Enzyme EC alpha beta delta gamma epsilon Acceptor
OT M00307 pyruvate:ferredoxin
oxidoreductase
1.2.7.1 K00169
porA
K00170
porB
K00171
porD
K00172
porC
ferredoxin
K03737
por
M00011 2-oxoglutarate:ferredoxin
oxidoreductase
1.2.7.3 K00174
korA
K00175
korB
K00176
korD
K00177
korC
ferredoxin
2-oxoacid:ferredoxin oxidoreductase 1.2.7.11 K00174
oforA
K00175
oforB
ferredoxin
2-oxoisovalerate:ferredoxin
oxidoreductase
1.2.7.7 K00186
vorA
K00187
vorB
K00188
vorD
K00189
vorC
ferredoxin
OT indolepyruvate:ferredoxin
oxidoreductase
1.2.7.8 K00179
iorA
K00180
iorB
ferredoxin
K04090
OT phenylglyoxylate:NAD+
oxidoreductase
1.2.1.58 K18355
padG
K18356
padI
K18357
padE
K18358
padF
K18359
padH
NAD+

Reaction class similarity group

RG003 Oxidative decarboxylation of 2-oxoacid to form its CoA derivative
C00022
pyruvate
RC02742
C00024
acetyl-CoA


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Last updated: November 25, 2015