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Functional Hierarchies

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KEGG BRITE is a collection of manually created hierarchical text (htext) files capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships.

Some BRITE hierarchy files are computationally expanded, adding a hierarchy level or a tab-delimited column, by incorporating additional information. This is accomplished by the Join Brite operation of KEGG Mapper, which combines a BRITE hierarchy file (such as ATC drug classification) and a binary relation file (such as D number to target relationships extracted from KEGG DRUG).

Some other BRITE hierarchy files contain tab-delimited attributes that are manually added. Recently introduced BRITE table files are essentailly the same as such multi-column BRITE hierarchy files. Because the table representation is often easier to understand, certain hierarchy files for disease and drug information have been converted to table files.

Brite Mapping

KEGG BRITE mapping is the process to map molecular datasets, especially large-scale datasets in genomics, transcriptomics, proteomics, and metabolomics, to the BRITE functional hierarchies for biological interpretation of higher-level systemic functions.

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green Pathways and Ontologies
KEGG パスウェイマップ
BRITE 階層ファイル (英語ファイル)
BRITE 階層ファイル (日本語ファイル)
BRITE テーブルファイル (英語ファイル)
BRITE テーブルファイル (日本語ファイル)
red Genes and Proteins

Orthologs and modules
KEGG Orthology (KO) (K numbers)
KEGG modules (M/K numbers)
KEGG reaction modules
Protein families (K numbers)
Enzymes
Protein kinases
Protein phosphatases
Peptidases
Glycosyltransferases
LPS biosynthesis proteins
Lipid biosynthesis proteins
Polyketide biosynthesis proteins
Prenyltransferases
Amino acid related enzymes
Cytochrome P450
Photosynthesis proteins
Transcription factors
Transcription machinery
Messenger RNA biogenesis
Spliceosome
Ribosome
Ribosome biogenesis
Transfer RNA biogenesis
Translation factors
Chaperones and folding catalysts
Membrane trafficking Major update!
Ubiquitin system
Proteasome
DNA replication proteins
Chromosome
DNA repair and recombination proteins
Mitochondrial biogenesis
Transporters
Secretion system
Bacterial toxins
Two-component system
Bacterial motility proteins
Cytoskeleton proteins
Exosome
Prokaryotic defense system
G protein-coupled receptors
Enzyme-linked receptors
Cytokine receptors
Nuclear receptors
Ion channels
GTP-binding proteins
Cytokines
CAMs and their ligands
CD molecules
Proteoglycans
Glycosaminoglycan binding proteins
GPI-anchored proteins
Lectins
Antimicrobial resistance genes
RNA family (K numbers)
Non-coding RNAs
Annotation guide
Enzymes of 2-oxoacid metabolism (table)
Dioxygenases (table)
Ribosomal proteins (table)
RNA polymerases (table)
Photo/chemosynthetic capacities (table)
Signaling modules (table)
See: KEGG Annotation
blue Compounds and Reactions

Compounds (C numbers)
生体物質
Lipids
Phytochemical compounds
Bioactive peptides
内分泌攪乱物質
農薬
発がん物質
自然毒
Target-based classification of compouonds
Reactions (R/RC numbers)
Enzymatic reactions
IUBMB reaction hierarchy
Reaction class
Glycosyltransferase reactions
purple Drugs

Drug classifications (D/C numbers)
医療用医薬品の薬効分類   [+ 商品]
医療用医薬品のATC分類   [+ ターゲット]
医療用医薬品のUSP分類
一般用医薬品の分類   [+ 商品]
一般用医薬品のリスク区分   [+ 商品]
医薬品添加物
ターゲットに基づく医薬品分類
抗感染症薬
チトクロームP450の相互作用
抗悪性腫瘍薬 (table)
その他の医薬品クラス: KEGG DRUG 参照
Other drug information (D/E/C numbers)
米国の新薬 (table)
日本の新薬 (table)
米国のゲノムバイオマーカー (table)
日本のゲノムバイオマーカー (table)
日本のスイッチOTC薬 (table)
日本薬局方収載医薬品
漢方方剤と生薬
生薬
精油
メディカルハーブ
天然物の主要成分
Phytochemicals used as drugs
動物用医薬品分類
purple Diseases

Human diseases (H numbers)
ヒト疾患   [+ 遺伝子]
感染症疾患   [+ ゲノム]
ICD-10 による疾患分類
感染症法による感染症分類 (table)
特定疾患 (難病) (table)
Disease genes and markers
Cancer stages
Tumor markers (table)
Cancer-associated carbohydrates (table)
Carbohydrates in infections (table)
Drug resistance
AMR: KEGG signatures (table)
AMR: KEGG organisms (table)
AMR: beta-Lactamases (table)
その他の遺伝子: KEGG Pathogen 参照
red Organisms and Cells

Organisms
KEGG 生物種   [+ キーワード]
KEGG organisms in NCBI taxonomy
KEGG viruses in NCBI taxonomy New!
動物分類
植物分類
Photosynthetic organisms
Endosymbionts
植物病原体
Cells, tissues, and organs
ヒトの器官系
ヒトの細胞

Binary Relationships

The following binary relation files may be used in the KEGG Mapper tool Join Brite to computationally extend the Brite hierarchy file.
K number to:    EC number    Reaction    GO    COG    TC    CAZy
D number to:    Target    Enzyme    Transporter    Marker    Map number   
H number to:    Human gene    Pathogen genome   
KEGG organism code to:    Keywords   

Codes and Abbreviations


Last updated: September 1, 2016
KEGG GenomeNet Kanehisa Laboratories