Polyketide biosynthesis

Building blocks

  Carboxylic acids (R-COOH)
Starter units Extension units
Acetyl-CoA
Propionyl-CoA
Malonyl-CoA
Butyryl-CoA
Isobutyryl-CoA
Acetoacetyl-CoA
Methylmalonyl-CoA
Pentanoyl-CoA
2-Methylbutyryl-CoA
3-Methylbutyryl-CoA
Ethylmalonyl-CoA
Hexanoyl-CoA

Chain elongation

Acyl transferase (AT) Ketoacyl synthase (KS)

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Functional group modifications

Keto reductase (KR) Dehydratase (DH) Enoyl reductase (ER)