The KEGG pathway maps for 14 cancers are drawn in a stage-dependent manner; how different signaling pathways and cancer-related genes are involved at different stages of oncogenesis. This is summarized in the following BRITE hierarchy file:

Cancer stages

together with links to the snapshots of involved pathways in the signaling overview map and the individual maps.

The KEGG pathway maps for 14 cancers contain oncogenes and tumor suppressor genes with genetic alterations summarized in the gray box and also marked in red in the pathway. This is based on literature data. In contrast, the COSMIC database contains actual observations of genetic alterations in cancer genomes. Here the COSMIC data for 17 cancers (see detail of selecting COSMIC site and histology) are mapped against KEGG pathway using the Color Pathway tool of KEGG Mapper. The result is shown as static png files in the following cosmic links.


Alternatively, a preliminary version of the 3D map viewer may be used. This tool is based on WebGL and runs on Firefox, Chrome, and WebGL-enabled Safari browsers.

Pathways in cancer with 3D map viewer New!