KEGG image  Pharmacogenomic Biomarkers

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Somatic variations in targeted cancer therapies

Drug KEGG ATC Product Target Biomarker KEGG
VARIANT
KEGG
NETWORK
Tegafur, gimeracil and oteracil potassium D06399 L01BC53 Ts-1 ESR1 positive
HER2 negative
2099v1
Imatinib D01441 L01EA01 Gleevec BCR-ABL
FIP1L1-PDGFRA
KIT
PDGFR
Philadelphia chromosome (BCR-ABL fusion gene)
FIP1L1-PDGFRA fusion gene
KIT mutation D816V negative
PDGFR rearrangement
25v1



nt06276
Dasatinib D06414 L01EA02 Sprycel BCR-ABL Philadelphia chromosome, BCR-ABL T315I mutation 25v2 nt06276
Nilotinib D06413 L01EA03 Tasigna BCR-ABL Philadelphia chromosome (BCR-ABL fusion gene)
UGT1A1*28 allele homozygotes
25v2
54658v1
nt06276
Bosutinib D09728 L01EA04 Bosulif BCR-ABL Philadelphia chromosome (BCR-ABL fusion gene) 25v2 nt06276
Ponatinib D09951 L01EA05 Iclusig BCR-ABL Philadelphia chromosome, (BCR-ABL fusion gene) T315I mutation 25v2 nt06276
Asciminib D11404 L01EA06 Scemblix BCR-ABL Philadelphia chromosome, (BCR-ABL fusion gene) T315I mutation 25v1
25v2
nt06276
Gefitinib D01977 L01EB01 Iressa EGFR EGFR exon 19 deletion or exon 21 L858R mutation 1956v2 nt06266
Erlotinib D04023 L01EB02 Tarceva EGFR EGFR exon 19 deletion or exon 21 L858R mutation 1956v2 nt06266
Afatinib D09733 L01EB03 Giotrif EGFR EGFR exon 19 deletion or exon 21 L858R mutation 1956v2 nt06266
Osimertinib D10766 L01EB04 Tagrisso EGFR EGFR T790M mutation 1956v3 nt06266
Dacomitinib D10514 L01EB07 Vizimpro EGFR EGFR exon 19 deletion or exon 21 L858R mutation 1956v2 nt06266
Mobocertinib D11969 L01EB10 Exkivity EGFR EGFR exon 20 insertion mutation 1956v2
Vemurafenib D09996 L01EC01 Zelboraf BRAF BRAF V600E mutation
NRAS mutation
673v1 nt06268
Dabrafenib D10104 L01EC02 Tafinlar BRAF BRAF V600E mutation
G6PD deficiency
673v1 nt06268
Encorafenib D11053 L01EC03 Braftovi BRAF BRAF V600E/K mutation 673v1 nt06268
Crizotinib D09731 L01ED01 Xalkori EML4-ALK
ROS1
EML4-ALK fusion gene
ROS1 fusion gene
238v1
6098v1
nt06266
Ceritinib D10551 L01ED02 Zykadia EML4-ALK ALK gene rearrangement 238v2 nt06266
Alectinib D10450 L01ED03 Alecensa EML4-ALK ALK gene rearrangement 238v2 nt06266
Brigatinib D10866 L01ED04 Alunbrig EML4-ALK ALK gene rearrangement 238v2 nt06266
Lorlatinib D11012 L01ED05 Lorbrena EML4-ALK ALK gene rearrangement 238v2 nt06266
Trametinib D10176 L01EE01 Mekinist MEK BRAF V600E/K mutation 673v1 nt06268
Cobimetinib D10615 L01EE02 Cotellic MEK BRAF V600E/K mutation 673v1 nt06268
Binimetinib D10604 L01EE03 Mektovi MEK BRAF V600E/K mutation 673v1 nt06268
Palbociclib D10372 L01EF01 Ibrance CDK4/6 ESR1 positive
HER2 negative
2099v1
Ribociclib D10979 L01EF02 Kisqali CDK4/6 ESR1 positive
HER2 negative
2099v1
Abemaciclib D10688 L01EF03 Verzenio CDK4/6 ESR1 positive
HER2 negative
MKI67 score
Everolimus D02714 L01EG02
L04AH02
Afinitor
Zortress
MTOR ESR1 positive
HER2 negative
2099v1
Lapatinib D04024 L01EH01 Tykerb EGFR
HER2
HER2 positive
ESR1, PGR positive
HLA-DQA1*0201 or HLA-DRB1*0701 allele carrier
2064v1 nt06270
Neratinib D10898 L01EH02 Nerlynx EGFR
HER2
HER4
HER2 positive 2064v1
2064v3
nt06270
Tucatinib D11141 L01EH03 Tukysa HER2
HER3
HER2 positive
RAS wild type
2064v1
2064v3
nt06270
Momelotinib D10889 L01EJ04 Ojjaara JAK1
JAK2
ACVR1
JAK2 mutation 3717v1
Fruquintinib D11977 L01EK04 Fruzaqla VEGFR1
VEGFR2
VEGFR3
RAS wild type
Ibrutinib D10223 L01EL01 Imbruvica BTK Chromosome 17p deletion
Chromosome 11q deletion
Alpelisib D11011 L01EM03 Piqray PIK3CA PIK3CA mutation
ESR1 positive
HER2 negative
5290v1
2099v1
nt06270
Erdafitinib D10927 L01EN01 Balversa FGFR3
FGFR2
FGFR3,2 genetic alterations 2261v2
2263v2
nt06265
Pemigatinib D11417 L01EN02 Pemazyre FGFR2 FGFR2 fusion gene 2263v2
Infigratinib D11611 L01EN03 Truseltiq FGFR2
FGFR1
FGFR3
FGFR2 mutation 2263v2
2263v1
Futibatinib D11725 L01EN04 Lytgobi FGFR2 FGFR2 fusion gene 2263v2
Midostaurin D05029 L01EX10 Rydapt FLT3 (CD135) FLT3 mutation 2322v1
2322v2
Quizartinib D09956 L01EX11 Vanflyta FLT3 (CD135) FLT3 mutation 2322v2
Larotrectinib D11138 L01EX12 Vitrakvi TRKA TRK positive
Gilteritinib D10800 L01EX13 Xospata FLT3 (CD135) FLT3 mutation 2322v1
2322v2
Entrectinib D10926 L01EX14 Rozlytrek NTRK1
ROS1
NTRK1 fusion gene
ROS1 fusion gene
4914v1
6098v1
Capmatinib D10891 L01EX17 Tabrecta MET MET exon 14 skipping 4233v4 nt06266
Avapritinib D11279 L01EX18 Ayvakit KIT
PDGFRA
KIT mutation
PDGFRA mutation
3815v1
5156v2
Tepotinib D11073 L01EX21 Tepmetko MET MET exon 14 skipping 4233v4 nt06266
Selpercatinib D11713 L01EX22 Retevmo RET RET fusion positive 5979v1
5979v2
nt06274
nt06266
Pralsetinib D11712 L01EX23 Gavreto RET RET fusion positive 5979v1 nt06266
Capivasertib D11371 L01EX27 Truqap AKT HER2 negative
ESR1 positive
PIK3CA/AKT1/PTEN mutations
207v1
2099v1
nt06530
Repotrectinib D11454 L01EX28 Augtyro ROS1
NTRK1
NTRK2
NTRK3
ROS1 fusion gene 6098v1
Rituximab D02994 L01FA01 Rituxan CD20 CD20 positive
Ofatumumab D09314 L01FA02 Arzerra CD20 CD20 positive
Obinutuzumab D09321 L01FA03 Gazyva CD20 CD20 positive
Inotuzumab ozogamicin D08933 L01FB01 Besponsa CD22 CD22 positive
Trastuzumab D03257 L01FD01 Herceptin HER2 HER2 overexpression 2064v1 nt06270
nt06261
Pertuzumab D05446 L01FD02 Perjeta HER2 HER2 positive 2064v1
2064v3
nt06270
Trastuzumab emtansine D09980 L01FD03 Kadcyla HER2 HER2 positive 2064v1
2064v3
nt06270
Trastuzumab deruxtecan D11529 L01FD04 Enhertu HER2 HER2 positive 2064v1
2064v3
nt06270
Margetuximab D10446 L01FD06 Margenza HER2 HER2 positive 2064v1
2064v3
Cetuximab D03455 L01FE01 Erbitux EGFR EGFR expression
KRAS wild type
BRAF V600E mutation
673v1
Panitumumab D05350 L01FE02 Vectibix EGFR EGFR expression, KRAS wild type nt06270
Nivolumab D10316 L01FF01 Opdivo PD1 PDL1 positive
BRAF V600 mutation
Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Pembrolizumab D10574 L01FF02 Keytruda PD1 PDL1 positive
Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
HER2 negative
ESR1, PGR negative
Durvalumab D10808 L01FF03 Imfinzi PDL1 PDL1 positive
Avelumab D10817 L01FF04 Bavencio PDL1 PDL1 positive
Atezolizumab D10773 L01FF05 Tecentriq PDL1 PDL1 positive
HER2 negative
ESR1, PGR negative
BRAF V600E/K mutation
Cemiplimab D11108 L01FF06 Libtayo PD1 PDL1 positive
Dostarlimab D11366 L01FF07 Jemperli PDCD1 Mismatch repair deficiency (dMMR)
Ramucirumab D09371 L01FG02 Cyramza VEGFR2 EGFR exon 19 deletion or exon 21 L858R mutation 1956v2
Gemtuzumab ozogamicin D03259 L01FX02 Mylotarg CD33 CD33 positive
Ipilimumab D04603 L01FX04 Yervoy CTLA4 Microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR)
Brentuximab vedotin D09587 L01FX05 Adcetris CD30 CD30 positive
Dinutuximab D10559 L01FX06 Unituxin GD2 MYCN amplification
Blinatumomab D09325 L01FX07 Blincyto CD19 Philadelphia chromosome (BCR-ABL fusion gene) negative
Mogamulizumab D09761 L01FX09 Poteligeo CCR4 CCR4 positive
Tafasitamab D11601 L01FX12 Monjuvi CD19 CD19 positive
Sacituzumab govitecan D10985 L01FX17 Trodelvy TOP1
TACSTD2
HER2 negative
ESR1 positive
2099v1
Amivantamab D11894 L01FX18 Rybrevant EGFR
MET
EGFR exon 20 insertion mutation 1956v2
Olaparib D09730 L01XK01 Lynparza PARP1 BRCA1,2 mutation
HER2 negative
672v1
675v1
Niraparib D11895 L01XK02 Zejula PARP1 BRCA1,2 mutation or wild type 672v1
675v1
Rucaparib D10982 L01XK03 Rubraca PARP1 BRCA1,2 mutation 672v1
675v1
Talazoparib D10733 L01XK04 Talzenna PARP1/2 BRCA1,2 mutation
HER2 negative
Homologous recombination repair gene (HRR) mutations
672v1
675v1
Tisagenlecleucel-T D11386 L01XL04 Kymriah CD19 CD19 positive
Omacetaxine D08956 L01XX40 Synribo CCND1 Philadelphia chromosome (BCR-ABL fusion gene) negative
Venetoclax D10679 L01XX52 Venclexta BCL2 Chromosome 17p deletion
Enasidenib D11044 L01XX59 Idhifa IDH2 IDH2 mutation 3418v1
Ivosidenib D11090 L01XX62 Tibsovo IDH1 IDH1 mutation 3417v1
Olutasidenib D12483 (L01XM03) Rezlidhia IDH1 IDH1 mutation 3417v1
Tazemetostat D11485 L01XX72 Tazverik EZH2 EZH2 mutation positive 2146v1
Sotorasib D12055 L01XX73 Lumakras KRAS KRAS mutation 3845v1 nt06266
Tebentafusp D12296 L01XX75 Kimmtrak CD3D
CD3E
CD3G
HLA-A*0201 positive
Adagrasib D12301 L01XX77 Krazati KRAS KRAS mutation 3845v1
Mirvetuximab soravtansine D10954 L01FX26 Elahere FOLR1
TUBB
FOLR1 positive
Tamoxifen D00966 L02BA01 Nolvadex NR3A (ESR) ESR1, PGR positive
Factor V Leiden negative
Prothrombin G20210A negative
2099v1
2153v1
2147v1
Fulvestrant D01161 L02BA03 Faslodex NR3A (ESR) ESR1, PGR positive
HER2 negative
Elacestrant D11672 L02BA04 Orserdu NR3A1 (ESR1) ER positive
ESR1 mutation
HER2 negative
2099v1
2099v2
Anastrozole D00960 L02BG03 Arimidex CYP19A1 (ARO) ESR1, PGR positive 2099v1
Letrozole D00964 L02BG04 Femara CYP19A1 (ARO) ESR1, PGR positive 2099v1
Exemestane D00963 L02BG06 Aromasin CYP19A1 (ARO) ESR1, PGR positive 2099v1
Satralizumab D11079 L04AC19 Enspryng IL6R anti-AQP4 antibody positive
Inebilizumab D11757 L04AG10 Uplizna CD19 anti-AQP4 antibody positive
Rozanolixizumab D12182 L04AG16 Rystiggo FCGRT anti-ACHR antibody positive
anti-MUSK antibody positive
Eculizumab D03940 L04AJ01 Soliris C5 anti-ACHR antibody positive
anti-AQP4 antibody positive
Ravulizumab D11054 L04AJ02 Ultomiris C5 anti-ACHR antibody positive
Zilucoplan D12356 L04AJ06 Zilbrysq C5 anti-ACHR antibody positive
Ibritumomab tiuxetan D04489 V10XX02 Zevalin CD20 CD20 positive
Lutetium (177Lu) dotatate D11033 V10XX04 Lutathera SSTR2 somatostatin receptor (SSTR) positive
Lutetium Lu 177 vipivotide tetraxetan D12335 V10XX05 Pluvicto FOLH1 PSMA positive
Letrozole and ribociclib D11068 Kisqali femara ESR1, PGR positive
HER2 negative
2099v1

Germline mutations in genetic disorder treatments

Drug KEGG ATC Product KEGG
DISEASE
Biomarker KEGG
VARIANT
KEGG
NETWORK
Setmelanotide D11928 A08AA12 Imcivree H02106
H02060
H02105
LEPR, PCSK1, POMC deficiency
Carglumic acid D07130 A16AA05 Carbaglu H01032 NAGS deficiency (CPS1 activator) 162417v1 nt06010
Imiglucerase D03020 A16AB02 Cerezyme H00126 GBA deficiency (enzyme replacement) 2629v1 nt06014
Agalsidase alpha D02784 A16AB03 Replagal H00125 GLA deficiency (enzyme replacement) 2717v1 nt06014
Agalsidase beta D03228 A16AB04 Fabrazyme H00125 GLA deficiency (enzyme replacement) 2717v1 nt06014
Laronidase D04670 A16AB05 Aldurazyme H00128 IDUA deficiency (enzyme replacement) 3425v1 nt06012
Sacrosidase D05782 A16AB06 Sucraid H00115 SI deficiency (enzyme replacement) 6476v1
Alglucosidase alfa D03207 A16AB07 Lumizyme H01940 GAA deficiency (enzyme replacement) 2548v1 nt06017
Galsulfase D06565 A16AB08 Naglazyme H00131 ARSB deficiency (enzyme replacement) 411v1 nt06012
Idursulfase D04499 A16AB09 Elaprase H00129 IDS deficiency (enzyme replacement) 3423v1 nt06012
Velaglucerase alfa D09029 A16AB10 Vpriv H00126 GBA deficiency (enzyme replacement) 2629v1 nt06014
Taliglucerase alfa D09675 A16AB11 Elelyso H00126 GBA deficiency (enzyme replacement) 2629v1 nt06014
Elosulfase D10333 A16AB12 Vimizim H00123 GALNS deficiency (enzyme replacement) 2588v1 nt06012
Asfotase alfa D10595 A16AB13 Strensiq H00213 ALPL deficiency (enzyme replacement) 249v1
Sebelipase alfa D10377 A16AB14 Kanuma H00148 LIPA deficiency (enzyme replacement) 3988v1
Velmanase alfa D11024 A16AB15 Lamzede H00139 MAN2B1 deficiency (enzyme replacement) 4125v1
Idursulfase beta D11025 A16AB16 Hunterase H00129 IDS deficiency (enzyme replacement) 3423v1 nt06012
Cerliponase alfa D10813 A16AB17 Brineura H00149 TPP1 deficiency (enzyme replacement) 1200v1
Vestronidase alfa D11004 A16AB18 MepseVII H00132 GUSB deficiency (enzyme replacement) 2990v1 nt06012
Pegvaliase D11077 A16AB19 Palynziq H00167 PAH deficiency (substitution by PAL activity) 5053v1
Pegunigalsidase alfa D11685 A16AB20 Elfabrio H00125 GLA deficiency (enzyme replacement) 2717v1
Avalglucosidase alfa D11744 A16AB22 Nexviazyme H01940 GAA deficiency (enzyme replacement) 2548v1 nt06017
Cipaglucosidase alfa D11798 A16AB23 Pombiliti H01940 GAA deficiency (enzyme replacement) 2548v1 nt06017
Olipudase alfa D10820 A16AB25 Xenpozyme H00137 SMPD1 deficiency (enzyme replacement) 6609v1
Eladocagene exuparvovec D12407 A16AB26 Upstaza H01161 DDC deficiency (gene therapy) 1644v1 nt06028
Sodium phenylbutyrate D05868 A16AX03 Buphenyl H01398 ASS1, CPS1, OTC deficiency 445v1
1373v1
5009v1
Nitisinone D05177 A16AX04 Orfadin H00165 FAH deficiency (HPD inhibitor) 2184v1 nt06016
Miglustat D05032 A16AX06 Zavesca H00126 GBA deficiency (UGCG inhibitor) 2629v1 nt06014
Sapropterin D01798 A16AX07 Kuvan H00167 QDPR deficiency (cofactor replacement) 5860v1 nt06016
Glycerol phenylbutyrate D10127 A16AX09 Ravicti H01398 ASS1, CPS1, OTC deficiency 445v1
1373v1
5009v1
Eliglustat D09894 A16AX10 Cerdelga H00126 GBA deficiency (UGCG inhibitor)
CYP2D6 polymorphism
2629v1 nt06014
Migalastat D05031 A16AX14 Galafold H00125 GLA variant (migalastat amenable) 2717v2 nt06014
Triheptanoin D11465 A16AX17 Dojolvi ACADVL, CPT2, HADHA, HADHB mutation (fatty acid supplement)
Lumasiran D11926 A16AX18 Oxlumo H00117 AGXT mutation
Fosdenopterin D11780 A16AX19 Nulibry H02311 MOCS1 deficiency (cofactor replacement) 4337v1 nt06025
Lonafarnib D04768 A16AX20 Zokinvy H00601 LMNA mutation
ZMPSTE24 mutation
Elapegademase D11017 L03AX21 Revcovi H02309 ADA deficiency (enzyme replacement) 100v1
Efgartigimod alfa D11876 L04AA58 Vyvgart H01594 anti-ACHR antibody positive
Eteplirsen D09900 M09AX06 Exondys 51 H01963 DMD mutation (exon 51 skipping amenable) 1756v1
Golodirsen D11707 M09AX08 Vyondys 53 H01963 DMD mutation (exon 53 skipping amenable) 1756v1
Onasemnogene abeparvovec D11559 M09AX09 Zolgensma H00455 bi-allelic SMN1 mutations
Viltolarsen D11528 M09AX12 Viltepso H01963 DMD mutation (exon 53 skipping amenable) 1756v1
Casimersen D11988 M09AX13 Amondys 45 H01963 DMD mutation (exon 45 skipping amenable) 1756v1
Ganaxolone D04300 N03AX27 Ztalmy H01819 CDKL5 mutation
Tofersen D11811 N07XX22 Qalsody H00058 SOD1 mutation 6647v1
Ivacaftor D09916 R07AX02 Kalydeco H00218 CFTR mutation 1080v1
Lumacaftor and ivacaftor D10685 R07AX30 Orkambi H00218 CFTR mutation 1080v1
Tezacaftor and ivacaftor D11042 R07AX31 Symdeko H00218 CFTR mutation 1080v1
Elexacaftor, ivacaftor and tezacaftor D11700 R07AX32 Trikafta H00218 CFTR mutation 1080v1
Apadamtase alfa and cinaxadamtase alfa D12835 Adzynma H00225 ADAMTS13 mutation (enzyme replacement)

Pathogen genome variants in infectious disease treatments

Drug KEGG ATC Product Target Biomarker
Maraviroc D06670 J05AX09 Selzentry CCR5 CCR5-tropic HIV-1 (R5 variant)

Polymorphisms and mutations affecting drug response

Drug KEGG ATC Biomarker KEGG
VARIANT
Omeprazole D00455
D05259
A02BC01 CYP2C19 polymorphism 1557v1
Pantoprazole D02593 A02BC02 CYP2C19 polymorphism 1557v1
Lansoprazole D00355 A02BC03 CYP2C19 polymorphism 1557v1
Rabeprazole D00724 A02BC04 CYP2C19 polymorphism 1557v1
Esomeprazole D01984
D04056
D10120
A02BC05 CYP2C19 polymorphism 1557v1
Dexlansoprazole D08903 A02BC06 CYP2C19 polymorphism 1557v1
Metoclopramide D05008 A03FA01 CYB5R deficiency
G6PD deficiency

2539v1
Palonosetron D05343 A04AA05 CYP2D6 polymorphism 1565v1
Dronabinol D00306 A04AD10 CYP2C9 polymorphism 1559v1
Odevixibat D11716 A05AX05 ABCB11 mutation 8647v1
Sulfasalazine D00448 A07EC01 G6PD deficiency 2539v1
Glibenclamide (Glyburide) D00336 A10BB01 G6PD deficiency 2539v1
Chlorpropamide D00271 A10BB02 G6PD deficiency 2539v1
Glipizide D00335 A10BB07 G6PD deficiency 2539v1
Glimepiride D00593 A10BB12 G6PD deficiency 2539v1
Nateglinide D01111 A10BX03 CYP2C9 polymorphism 1559v1
Warfarin D00564 B01AA03 VKORC1 rs9923231
CYP2C9 polymorphism
PROC deficiency
PROS deficiency
79001v1
1559v1

 
Clopidogrel D00769 B01AC04 CYP2C19 polymorphism 1557v1
Ticagrelor D09017 B01AC24 CYP2C19 polymorphism 1557v1
Eltrombopag D03978 B02BX05 Factor V Leiden
ATIII deficiency
2153v1
 
Lusutrombopag D10476 B02BX07 Factor V Leiden
Prothrombin 20210A
ATIII deficiency
PROC deficiency
PROS deficiency
2153v1
2147v1


 
Avatrombopag D10307 B02BX08 Factor V Leiden
Prothrombin 20210A
ATIII deficiency
PROC deficiency
PROS deficiency
2153v1
2147v1


 
Quinidine D00642
D02272
C01BA01 CYP2D6 polymorphism 1565v1
Procainamide D08421
D00477
C01BA02 NAT polymorphism 9v1
10v1
Propafenone D00640 C01BC03 CYP2D6 polymorphism 1565v1
Isosorbide dinitrate D00516 C01DA08 CYB5R deficiency
Isosorbide mononitrate D00630 C01DA14 CYB5R deficiency
Mavacamten D12265 C01EB24 CYP2C19 polymorphism 1557v1
Hydralazine and isosorbide D10209 NAT polymorphism 9v1
10v1
Propranolol D00483 C07AA05 CYP2D6 polymorphism 1565v1
Metoprolol D00601
D00635
C07AB02 CYP2D6 polymorphism 1565v1
Carvedilol D00255
D03415
C07AG02 CYP2D6 polymorphism 1565v1
Rosuvastatin D01915 C10AA07 SLCO1B1 polymorphism
Doxepin D00814 D04AX01
N06AA12
CYP2C19 polymorphism
CYP2D6 polymorphism
1557v1
1565v1
Amikacin D00865 D06AX12 MT-RNR1 (m.1555A>G) 4549v1
Mafenide D01166 D06BA03 G6PD deficiency 2539v1
Dapsone D00592 D10AX05
J04BA02
G6PD deficiency 2539v1
Abrocitinib D11400 D11AH08 CYP2C19 polymorphism 1557v1
Flibanserin D02577 G02CX02 CYP2C9 polymorphism
CYP2C19 polymorphism
CYP2D6 polymorphism
1559v1
1557v1
1565v1
Drospirenone and ethinylestradiol D09741 G03AA12 CYP2C19 polymorphism 1557v1
Tolterodine D01148 G04BD07 CYP2D6 polymorphism 1565v1
Darifenacin D01699 G04BD10 CYP2D6 polymorphism 1565v1
Fesoterodine D08923 G04BD11 CYP2D6 polymorphism 1565v1
Elagolix D09336 H01CC03 SLCO1B1 polymorphism
Parathyroid hormone D05364 H05AA03 CASR positive
Sulfamethoxazole and trimethoprim D00285 J01EE01 G6PD deficiency 2539v1
Tobramycin D00063 J01GB01 MT-RNR1 (m.1555A>G) 4549v1
Plazomicin D10655 J01GB14 MT-RNR1 (m.1555A>G) 4549v1
Nalidixic acid D00183 J01MB02 G6PD deficiency 2539v1
Nitrofurantoin D00439 J01XE01 G6PD deficiency 2539v1
Voriconazole D00578 J02AC03 CYP2C19 polymorphism 1557v1
Rifampin, isoniazid, and pyrazinamide D10210 J04AM05 NAT polymorphism 9v1
10v1
Abacavir D00891 J05AF06 HLA-B*5701
Efavirenz D00896 J05AG03 CYP2B6 1555v1
Dolutegravir D10113 J05AJ03 UGT1A1 polymorphism 54658v1
Sofosbuvir D10366 J05AP08 IL28B rs12979860 282617v1
Dasabuvir, ombitasvir,
paritaprevir and ritonavir
D10582 J05AP52 IL28B rs12979860 282617v1
Elbasvir and grazoprevir D10778 J05AP54 IL28B allele carrier
Mercaptopurine D00161 L01BB02 TPMT polymorphism 7172v1
Thioguanine D06109 L01BB03 TPMT polymorphism 7172v1
Fluorouracil D00584 L01BC02 DPYD deficiency
Capecitabine D01223 L01BC06 DPYD deficiency
Irinotecan D01061 L01CE02 UGT1A1 polymorphism 54658v1
Lapatinib D04024 L01EH01 HLA-DQA1*0201
HLA-DRB1*0701
Nilotinib D06413 L01EA03 UGT1A1 polymorphism 54658v1
Pazopanib D05380 L01EX03 UGT1A1 polymorphism 54658v1
Sacituzumab govitecan D10985 L01FX17 UGT1A1 polymorphism 54658v1
Cisplatin D00275 L01XA01 TPMT polymorphism 7172v1
Belinostat D08870 L01XH04 UGT1A1 polymorphism 54658v1
Belzutifan D11954 L01XX74 CYP2C19 polymorphism
UGT2B17 polymorphism
1557v1
Peginterferon alfa-2b D02748 L03AB10 IL28B rs12979860
Mycophenolic acid D00752
D05095
D05096
L04AA06 HPRT deficiency
Etrasimod D10931 L04AE05 CYP2C9 polymorphism 1559v1
Azathioprine D00238 L04AX01 TPMT polymorphism 7172v1
Lenalidomide D04687 L04AX04 Chromosome 5q deletion
Piroxicam D00127 M01AC01 CYP2C9 polymorphism 1559v1
Celecoxib D00567 L01XX33
M01AH01
CYP2C9 polymorphism 1559v1
Flurbiprofen D00330
D02290
M01AE09
M02AA19
R02AX01
S01BC04
CYP2C9 polymorphism 1559v1
Succinylcholine D00766 M03AB01 BCHE deficiency
Carisoprodol D00768 M03BA02 CYP2C19 polymorphism 1557v1
Allopurinol D07564 M04AA01 HLA-B*5801
Lesinurad D09921 M04AB05 CYP2C9 polymorphism 1559v1
Pegloticase D09316 M04AX02 G6PD deficiency
Sevoflurane D00547 N01AB08 RYR1 positive
Sodium oxybate D05866 N01AX11
N07XX04
ALDH5A1 deficiency
(Succinic semialdehyde dehydrogenase deficiency)
Prilocaine and lidocaine D02740 N01BB52
N01BB54
CYB5R deficiency
G6PD deficiency

2539v1
Tramadol and acetaminophen D09999 N02AJ13 CYP2D6 polymorphism 1565v1
Tramadol D01355 N02AX02 CYP2D6 polymorphism 1565v1
Oliceridine D11214 N02AX07 CYP2D6 polymorphism 1565v1
Phenytoin D00512
D02103
N03AB02 HLA-B*1502
Fosphenytoin D02096 N03AB05 HLA-B*1502
CYP2C9 polymorphism

1559v1
Carbamazepine D00252 N03AF01 HLA-B*1502
HLA-A*3101
Oxcarbazepine D00533 N03AF02 HLA-B*1502
Valproic acid D00399
D00304
D00710
N03AG01 POLG deficiency
CPS1,OTC,NAGS / ASS1,ASL / ARG deficiency
(Urea cycle disorders)
1373v1
5009v1
162417v1
445v1
435v1
383v1
Lacosamide D07299 N03AX18 CYP2C19 polymorphism 1557v1
Brivaracetam D08879 N03AX23 CYP2C19 polymorphism 1557v1
Perphenazine D00503 N05AB03 CYP2D6 polymorphism 1565v1
Thioridazine D00798 N05AC02 CYP2D6 polymorphism 1565v1
Pimozide D00560 N05AG02 CYP2D6 polymorphism 1565v1
Clozapine D00283 N05AH02 CYP2D6 polymorphism 1565v1
Risperidone D00426 N05AX08 CYP2D6 polymorphism 1565v1
Aripiprazole D01164
D10364
N05AX12 CYP2D6 polymorphism 1565v1
Iloperidone D02666 N05AX14 CYP2D6 polymorphism 1565v1
Brexpiprazole D10309 N05AX16 CYP2D6 polymorphism 1565v1
Diazepam D00293 N05BA01 CYP2C19 polymorphism 1557v1
Clobazam D01253 N05BA09 CYP2C19 polymorphism 1557v1
Desipramine D00812 N06AA01 CYP2D6 polymorphism 1565v1
Imipramine D00815 N06AA02 CYP2D6 polymorphism 1565v1
Clomipramine D00811 N06AA04 CYP2D6 polymorphism 1565v1
Amitriptyline D00809 N06AA09 CYP2D6 polymorphism 1565v1
Trimipramine D02408 N06AA06 CYP2D6 polymorphism 1565v1
Nortriptyline D00816 N06AA10 CYP2D6 polymorphism 1565v1
Protriptyline D00484 N06AA11 CYP2D6 polymorphism 1565v1
Fluoxetine D00823 N06AB03 CYP2D6 polymorphism 1565v1
Citalopram D00822 N06AB04 CYP2C19 polymorphism
CYP2D6 polymorphism
1557v1
1565v1
Paroxetine D02260
D05374
D05375
N06AB05 CYP2D6 polymorphism 1565v1
Fluvoxamine D00824 N06AB08 CYP2D6 polymorphism 1565v1
Escitalopram D02567 N06AB10 CYP2C19 polymorphism
CYP2D6 polymorphism
1557v1
1565v1
Nefazodone D00819 N06AX06 CYP2D6 polymorphism 1565v1
Venlafaxine D00821 N06AX16 CYP2D6 polymorphism 1565v1
Duloxetine D01179 N06AX21 CYP2D6 polymorphism 1565v1
Vortioxetine D10185 N06AX26 CYP2D6 polymorphism 1565v1
Modafinil D01832 N06BA07 CYP2D6 polymorphism 1565v1
Atomoxetine D02574 N06BA09 CYP2D6 polymorphism 1565v1
Chlordiazepoxide and amitriptyline D10207 N06CA01 CYP2D6 polymorphism 1565v1
Galantamine D02173 N06DA04 CYP2D6 polymorphism 1565v1
Lecanemab D11678 N06DX04 APOE epsilon4 homozygotes
Cevimeline D00661 N07AX03 CYP2D6 polymorphism 1565v1
Lofexidine D04765 N07BC04 CYP2D6 polymorphism 1565v1
Tetrabenazine D08575 N07XX06 CYP2D6 polymorphism 1565v1
Valbenazine D10999 N07XX13 CYP2D6 polymorphism 1565v1
Deutetrabenazine D10701 N07XX16 CYP2D6 polymorphism 1565v1
Dextromethorphan and quinidine D10208 N07XX59 CYP2D6 polymorphism 1565v1
Chloroquine D02125 P01BA01 G6PD deficiency 2539v1
Primaquine D02126 P01BA03 G6PD deficiency 2539v1
Tafenoquine D10670 P01BA07 G6PD deficiency 2539v1
Quinine sulfate D02262 P01BC01 G6PD deficiency
CYP2D6 polymorphism
2539v1
1565v1
Indacaterol D09319 R03AC18 UGT1A1 polymorphism 54658v1
Arformoterol D02981 UGT1A1 polymorphism
CYP2D6 polymorphism
54658v1
1565v1
Codeine D03580 R05DA04 CYP2D6 polymorphism 1565v1
Sodium nitrite D05865 V03AB08 G6PD deficiency 2539v1
Methylene blue D02312 V03AB17 G6PD deficiency 2539v1
Rasburicase D05704 V03AF07 G6PD deficiency
CYB5R deficiency
2539v1
Succimer D00572 G6PD deficiency 2539v1

See also: Pharmacogenomic biomarkers in drug labeling

[ DRUG | BRITE | KEGG2 | KEGG ]
Last updated: March 28, 2024