Join Brite is a third type of BRITE mapping (ontology enrichment) tool, which may be viewed as adding a new column (instead of adding color) to the existing BRITE functional hierarchy file.
This is done by combining a BRITE file with a binary (or higher) relation file consisting of objects (such as drugs) and attributes (such as their targets), which is is similar to the JOIN operation in relational database except that the BRITE file contains an additional column specifying the level of hierarchy.
The objects are specified by the following KEGG identifiers followed by tab-delimited attributes in a relation file.
| Prefix |
Category |
KEGG identifier |
| ko |
Genes and proteins |
K number |
| br |
Organisms and cells |
KEGG organism code |
| br |
Diseases and drugs |
H/D/E numbers |
| br |
Compounds and reactions |
C/G/R numbers |
When the binary relation file consists of one-to-one relationships, the result may be convieniently shown by an additional column to the existing BRITE file.
However if it consists of one-to-many relationships, the result may better be viewed and manipulated by showning the relationship in an additional hierarchy to the exisiting BRITE file. See example files for this distinction.
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Last updated: June 1, 2011
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