KEGG MEDICUS Search Result

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Entry Name Description Category Pathway Drug
H00001 B lymphoblastic leukemia/lymphoma Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic ... Cancer hsa05202 Transcriptional misregulation in cancers Vincristine [DG:DG00690]
Prednisone [DG:DG00094]
Daunorubicin [DG:DG00697]
Asparaginase [DR:D02997]
Methotrexate [DG:DG00681]
Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Dexamethasone [DG:DG00011]
Cytarabine [DG:DG00686]
6-mercaptopurine [DG:DG00683]
H00002 T lymphoblastic leukemia/lymphoma Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic ... Cancer hsa05202 Transcriptional misregulation in cancers Vincristine [DG:DG00690]
Prednisone [DG:DG00094]
Daunorubicin [DG:DG00697]
Asparaginase [DR:D02997]
Methotrexate [DG:DG00681]
Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Dexamethasone [DG:DG00011]
Cytarabine [DG:DG00686]
6-mercaptopurine [DG:DG00683]
H00003 Acute myeloid leukemia (AML) Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program ... Cancer hsa05221 Acute myeloid leukemia
hsa05202 Transcriptional misregulation in cancers
Cytarabine [DG:DG00686]
Daunorubicin [DG:DG00697]
Idarubicin [DG:DG00700]
Tretinoin [DR:D00094]
H00004 Chronic myeloid leukemia (CML) Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (CP) ... Cancer hsa05220 Chronic myeloid leukemia Imatinib mesylate (Gleevec) [DG:DG00710]
Nilotinib [DG:DG00716]
Dasatinib [DG:DG00714]
H00005 Chronic lymphocytic leukemia (CLL) B-cell chronic lymphocytic leukemia (CLL) is caused by the abnormal progressive accumulation of functionally incompetent monoclonal B-lymphocytes in blood, bone marrow, lymph nodes and spleen. It is the ... Cancer Fludarabine [DG:DG00685]
Cyclophosphamide [DG:DG00675]
Rituximab [DR:D02994]
Bendamustine [DG:DG00678]
Chlorambucil [DR:D00266]
H00006 Hairy-cell leukemia Hairy cell Leukemia (HCL) is a chronic lymphoproliferative disorder that is defined, according to the WHO classification, as a mature (peripheral) B-cell neoplasm. HCL accounts for between 2-3% of all ... Cancer hsa05202 Transcriptional misregulation in cancers Cladribine (2-chlorodeoxyadeosine; CdA) [DR:D01370]
H00007 Hodgkin lymphoma Hodgkin's lymphoma (HL) is one of the most frequent lymphomas in the Western world and often affects young adults. HL is subdivided into classical and nodular lymphocyte-predominant forms. About 95% of ... Cancer hsa05202 Transcriptional misregulation in cancers
hsa05203 Viral carcinogenesis
Doxorubicin (Adriamycin) [DG:DG00696]
Bleomycin [DG:DG00705]
Vinblastine [DG:DG00689]
Dacarbazine (ABVD) [DG:DG00680]
Mechlorethamine [DR:D07671]
Etoposide [DG:DG00693]
Vincristine [DG:DG00690]
Prednisone [DG:DG00094]
Cyclophosphamide [DG:DG00675]
Procarbazine [DG:DG00706]
Prednisone [DG:DG00094]
H00008 Burkitt lymphoma Burkitt lymphoma (BL) is a highly aggressive mature B-cell non-Hodgkin's lymphoma consisting of endemic, sporadic, and immunodeficiency-associated variants. Endemic BL (eBL) affects children and young ... Cancer hsa05203 Viral carcinogenesis Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Prednisone (CHOP) [DG:DG00094]
Rituximab [DR:D02994]
H00009 Adult T-cell leukemia Adult T-cell leukemia (ATL) is one of the most aggressive hematologic malignancies and is caused by human T-cell leukemia virus type I (HTLV-I). The HTLV-I Tax protein has been demonstrated to be the oncogenic ... Cancer hsa05166 HTLV-I infection
hsa05203 Viral carcinogenesis
Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Prednisone (CHOP) [DG:DG00094]
Rituximab [DR:D02994]
H00010 Multiple myeloma Multiple myeloma is a disorder in which malignant plasma cells accumulate, generally derived from one clone in the bone marrow. Intricate interactions occur between the bone-marrow microenvironment and ... Cancer hsa05202 Transcriptional misregulation in cancers Bortezomib [DR:D03150]
Dexamethasone [DG:DG00011]
Thalidomide [DR:D00754]
Lenalidomide [DG:DG00744]
Melphalan [DG:DG00676]
Prednisone [DG:DG00094]
H00011 Lymphoplasmacytic lymphoma Lymphoplasmacytic lymphoma (LPL)/Waldenstrom's macroglobulinemia (WM) is a non-Hodgkin lymphoma (NHL) subtype characterized by small B-lymphocytes, plasmacytoid lymphocytes, and plasma cells, usually involving ... Cancer hsa05202 Transcriptional misregulation in cancers Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Prednisone (CHOP) [DG:DG00094]
Rituximab [DR:D02994]
H00012 Polycythemia vera Polycythemia vera (PV) is a clonal myeloproliferative disease characterized by an erythroid dominant trilineage proliferation of hematopoietic precursor cells. PV belongs to the family of chronic myeloproliferative ... Cancer Hydroxyurea [DR:D00341]
H00013 Small cell lung cancer Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of ... Cancer hsa05222 Small cell lung cancer
hsa05206 MicroRNAs in cancer
Cisplatin [DR:D00275]
Etoposide [DG:DG00693]
Carboplatin [DR:D01363]
H00014 Non-small cell lung cancer Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heterogeneous ... Cancer hsa05223 Non-small cell lung cancer
hsa05206 MicroRNAs in cancer
Cisplatin [DR:D00275]
Vinorelbine [DG:DG00692]
Etoposide [DG:DG00693]
Paclitaxel [DG:DG01430]
Carboplatin [DR:D01363]
Gemcitabine [DG:DG00688]
Pemetrexed [DR:D07472]
Bevacizumab [DR:D06409]
H00015 Malignant pleural mesothelioma Malignant mesothelioma (MM) is a rare but very aggressive tumor that arises from mesothelial cells lining the pleural, peritoneal and pericardial cavities. Malignant pleural mesothelioma (MPM) is the most ... Cancer Cisplatin [DR:D00275]
Pemetrexed [DG:DG00682]
Carboplatin [DR:D01363]
Gemcitabine [DG:DG00688]
H00016 Oral cancer Oral cancer refers to a subgroup of head and neck malignancies that develop at the lips, tongue, salivary glands, gingiva, floor of the mouth, oropharynx, buccal surfaces and other intra-oral locations ... Cancer Cisplatin [DR:D00275]
Fluorouracil [DG:DG00687]
Paclitaxel [DG:DG01430]
Carboplatin [DR:D01363]
Docetaxel [DG:DG00694]
Cetuximab [DR:D03455]
H00017 Esophageal cancer Esophageal cancer represents the 9th leading cancer in the world and is associated with a 5-year survival rate under 25%. The two main forms are squamous-cell carcinoma (ECSC) and adenocarcinoma (EAC) ... Cancer hsa05206 MicroRNAs in cancer Cisplatin [DR:D00275]
Fluorouracil [DG:DG00687]
Paclitaxel [DG:DG01430]
Carboplatin [DR:D01363]
H00018 Gastric cancer Gastric cancer is the second most common cause of cancer-related death worldwide. There is substantial international variation in gastric cancer incidence with the highest rates reported from Korea, Japan ... Cancer Epirubicin [DG:DG00698]
Cisplatin [DR:D00275]
Fluorouracil [DG:DG00687]
Docetaxel [DG:DG00694]
Leucovorin [DR:D01211]
Oxaliplatin [DR:D01790]
Trastuzumab [DG:DG01358]
H00019 Pancreatic cancer Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). ... Cancer hsa05212 Pancreatic cancer Gemcitabine [DG:DG00688]
Cisplatin [DR:D00275]
Paclitaxel [DG:DG01430]
Erlotinib [DG:DG00711]
Fluorouracil [DG:DG00687]
Leucovorin (FOLFOX4) [DR:D01211 D04715]
Irinotecan [DG:DG00726]
Oxaliplatin [DR:D01790]
H00020 Colorectal cancer Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined ... Cancer hsa05210 Colorectal cancer
hsa05206 MicroRNAs in cancer
hsa00512 Mucin type O-glycan biosynthesis
5-Fluorouracil (5-FU) [DG:DG00687]
Leucovorin (FOLFOX4) [DR:D01211 D04715]
Oxaliplatin [DR:D01790]
Capecitabine [DR:D01223]
Irinotecan [DG:DG00726]
Bevacizumab [DR:D06409]
H00021 Renal cell carcinoma Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer ... Cancer hsa05211 Renal cell carcinoma
hsa05202 Transcriptional misregulation in cancers
Sunitinib [DG:DG00712]
Temsirolimus [DR:D06068]
Bevacizumab [DR:D06409]
Sorafenib [DG:DG00713]
Pazopanib [DR:D05380]
Interleukin-2 [DR:D00748]
Interferon-alpha [DR:D02745]
Axitinib [DR:D03218]
H00022 Bladder cancer The urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carcinoma ... Cancer hsa05219 Bladder cancer
hsa05206 MicroRNAs in cancer
Gemcitabine [DG:DG00688]
Cisplatin (M-VAC) [DR:D00275]
Methotrexate [DG:DG00681]
Vinblastine [DG:DG00689]
Doxorubicin (adriamycin) [DG:DG00696]
H00023 Testicular cancer Testicular germ cell tumor (TGCT) comprises about 98% of all testicular neoplasms and is thereby the most common malignancy among young males. Overall, three different entities of TGCT can be distinguished: ... Cancer Cisplatin [DR:D00275]
Etoposide [DG:DG00693]
Bleomycin [DG:DG00705]
Mesna [DR:D01459]
Ifosfamide [DR:D00343]
H00024 Prostate cancer Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key ... Cancer hsa05215 Prostate cancer
hsa05202 Transcriptional misregulation in cancers
hsa05206 MicroRNAs in cancer
Leuprolide [DR:D00989]
Goserelin [DG:DG00731]
Triptorelin [DG:DG00732]
Degarelix [DG:DG00736]
Flutamide [DR:D00586]
Bicalutamide [DR:D00961]
Nilutamide [DR:D00965]
H00025 Penile cancer Penile cancer is a disease with a high morbidity and mortality. Its prevalence is relatively rare in developed countries but more common in South America and East Africa. Squamous cell carcinoma (SCC) ... Cancer hsa05203 Viral carcinogenesis Bleomycin [DG:DG00705]
Cisplatin [DR:D00275]
Methotrexate [DG:DG00681]
Fluorouracil [DG:DG00687]
H00026 Endometrial Cancer Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial ... Cancer hsa05213 Endometrial cancer Progestin
Tamoxifen [DG:DG00734]
Aromatase inhibitors
Cisplatin [DR:D00275]
Doxorubicin [DR:D03899]
Carboplatin [DR:D01363]
Paclitaxel [DG:DG01430]
H00027 Ovarian cancer Ovarian cancer is the sixth most common cancer and the fifth leading cause of cancer-related death among women in developed countries. Approximately 90% of human ovarian cancer arises within the ovarian ... Cancer hsa05206 MicroRNAs in cancer Paclitaxel [DG:DG01430]
Carboplatin [DR:D01363]
Docetaxel [DG:DG00694]
Cisplatin [DR:D00275]
Gemcitabine [DR:D02368]
Doxorubicin [DR:D01275]
Topotecan [DR:D08618]
Cyclophosphamide [DR:D07760]
Etoposide [DR:D00125]
Bevacizumab [DR:D06409]
H00028 Choriocarcinoma Gestational choriocarcinoma is a highly malignant epithelial tumor that can be associated with any type of gestational event, most often a complete hydatidiform mole (CM). CM occur in about one per 1000 ... Cancer Methotrexate [DG:DG00681]
Dactinomycin [DR:D00214]
Etoposide [DG:DG00693]
Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
H00029 Vulvar cancer Vulvar cancer is a relatively uncommon malignancy, occurring at a rate of 2.2 per 100,000 women per year. Squamous cell carcinoma (SCC) is the most common type of vulvar cancer and is observed in 80% to ... Cancer Cisplatin [DR:D00275]
Bleomycin [DG:DG00705]
Fluorouracil [DG:DG00687]
Methotrexate [DG:DG00681]
Mitomycin [DR:D00208]
Doxorubicin [DG:DG00696]
H00030 Cervical cancer Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus ... Cancer hsa05203 Viral carcinogenesis Cisplatin [DR:D00275]
Paclitaxel [DG:DG01430]
Topotecan [DG:DG00725]
Carboplatin [DR:D01363]
Gemcitabine [DG:DG00688]
H00031 Breast cancer Breast cancer remains the most common malignancy in women worldwide and is the leading cause of cancer-related mortality. More than 1-2 million cases are diagnosed every year, affecting 10-12% of the female ... Cancer hsa05224 Breast cancer
hsa05206 MicroRNAs in cancer
Tamoxifen [DG:DG00734]
Anastrozole [DR:D00960]
Letrozole [DR:D00964]
Exemestane [DR:D00963]
Doxorubicin [DG:DG00696]
Cyclophosphamide [DG:DG00675]
Docetaxel [DG:DG00694]
Paclitaxel [DG:DG01430]
Trastuzumab [DG:DG01358]
Carboplatin [DR:D01363]
H00032 Thyroid cancer Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cells ... Cancer hsa05216 Thyroid cancer
hsa05202 Transcriptional misregulation in cancers
Sodium iodide I 131 [DR:D02259]
Sorafenib [DG:DG00713]
Sunitinib [DG:DG00712]
Pazopanib [DR:D05380]
Vandetanib [DR:D06407]
H00033 Adrenal carcinoma Adrenocortical carcinoma (ACC) is a rare endocrine malignancy defined by a heterogeneous clinical presentation, dismal prognosis, and lack of effective therapeutic regimens. The incidence of ACC ranges ... Cancer Mitotane [DR:D00420]
H00034 Carcinoid Carcinoid tumors are relatively uncommon neoplasms that nonetheless comprise up to 85% of neuroendocrine gastrointestinal neoplasms. They most frequently occur in the midgut and develop from neuroendocrine ... Cancer hsa05202 Transcriptional misregulation in cancers Streptozocin [DR:D05932]
Fluorouracil [DG:DG00687]
Bevacizumab [DR:D06409]
Sorafenib [DG:DG00713]
Sunitinib [DG:DG00712]
H00035 Ewing's sarcoma Ewing's sarcoma is the second most common malignant bone tumor occurring in children and young adults, and accounts for 10-15% of all primary bone tumors. The annual incidence is approximately 0.6/million ... Cancer hsa05202 Transcriptional misregulation in cancers Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Doxorubicin [DG:DG00696]
Dacarbazine [DG:DG00680]
Dactinomycin [DR:D00214]
Ifosfamide [DR:D00343]
Etoposide [DG:DG00693]
H00036 Osteosarcoma Osteosarcoma is the most common type of primary bone cancer. Approximately 900 new cases of osteosarcoma are diagnosed each year in the United States. The presentation of this disease is bimodal, with ... Cancer Doxorubicin [DG:DG00696]
Cisplatin [DR:D00275]
Ifosfamide [DR:D00343]
Methotrexate [DG:DG00681]
H00037 Alveolar rhabdomyosarcoma Rhabdomyosarcomas (RMSs) are soft tissue sarcomas that are one of the most common neoplasms in children and adolescents. RMSs are presumed to be associated with the skeletal muscle lineage, although those ... Cancer hsa05202 Transcriptional misregulation in cancers Doxorubicin [DG:DG00696]
Dacarbazine [DG:DG00680]
Ifosfamide [DR:D00343]
Mesna [DR:D01459]
Imatinib [DG:DG00710]
Sunitinib [DG:DG00712]
H00038 Malignant melanoma Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes. ... Cancer hsa05218 Melanoma Ipilimumab [DR:D04603]
Vemurafenib [DR:D09996]
Interleukin-2
H00039 Basal cell carcinoma Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial ... Cancer hsa05217 Basal cell carcinoma Cisplatin [DR:D00275]
Doxorubicin [DG:DG00696]
H00040 Squamous cell carcinoma Non-melanoma skin cancer, i.e. basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most frequent tumors and their number is still increasing world- wide. Approximately 200000 cases of ... Cancer Cisplatin [DR:D00275]
Doxorubicin [DG:DG00696]
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