ERK signaling |
N00001 |
| | EGF | → | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK | → | CCND1 |
N00367 |
E5 | ⊣ | V-ATPase | ⊣ | EGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00015 |
| | PDGF | → | PDGFR | → | GRB2 | → | SOS | → | RAS | → | RAF | → | MEK | → | ERK |
N00369 |
| | E5 | → | PDGFRB |
| | |
PI3K signaling |
N00033 |
| | EGF | → | EGFR | → | PI3K | → | PIP3 | → | AKT | ⊣ | BAD |
N00366 |
E5 | ⊣ | V-ATPase | ⊣ | EGFR |
N00039 |
| | PDGF | → | PDGFR | → | PI3K | → | PIP3 | → | AKT | → | MTOR | → | S6K |
N00368 |
| | E5 | → | PDGFRB |
N00582 |
| | IGF1 | → | IGF1R | → | PI3K | → | PIP3 | → | AKT | ⊣ | (TSC1+TSC2) | ⊣ | RHEB | → | MTOR | ⊣ | EIF4EBP1 |
N00357 |
| | | | | | | | | | (E6+UBE3A) | ⊣ | (TSC1+TSC2) |
N00220 |
| | | | | | PTEN | ⊣ | PIP3 | → | AKT |
N00353 |
| | E6 | ⊣ | SLC9A3R1 | → | PTEN |
N00354 |
| | | | E6 | ⊣ | PTEN |
N00355 |
| | | | | | | | PP2A | ⊣ | AKT |
N00356 |
| | | | | | E7 | ⊣ | PP2A |
| | |
NOTCH signaling |
N00086 |
| | (DLL,JAG) | → | NOTCH | → | (NICD+RBPJ) | ⇒ | (HES1,HEY1) |
N00380 |
E6 | → | JAG1 | → | NOTCH | → | (NICD+RBPJ+MAML) | ⇒ | (HES1,HEY1) |
N00381 |
E6 | ⊣ | MFNG | ⊣ | NOTCH | → | (NICD+RBPJ+MAML) | ⇒ | (HES1,HEY1) |
N00382 |
E6 | → | (NFX1+PSEN1) | → | NOTCH | → | (NICD+RBPJ+MAML) | ⇒ | (HES1,HEY1) |
| | |
TLR signaling |
N00149 |
TLR3 | → | TICAM1 | → | TRAF3 | → | (IKBKE+TBK1) | → | IRF3 | → | (CREBBP,EP300) | ⇒ | IFNB1 |
N00346 |
| | | | | | E6 | ⊣ | IRF3 |
| | |
IFN signaling |
N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
N00377 |
| | E6 | ⊣ | TYK2 |
N00378 |
| | | | E6 | ⊣ | (STAT1+STAT2+IRF9) |
N00379 |
| | | | E7 | ⊣ | (STAT1+STAT2+IRF9) |
| | |
TNF signaling |
N00374 |
TNF | → | TNFRSF1B | → | IRF1 | ⇒ | IFNB1 |
N00375 |
| | (E7+HDAC+CHD4) | ⊣ | IRF1 |
| | |
MHC presentation |
N00363 |
TAP1/2 | = | TAPBP | = | (PDIA3+CALR) | → | (MHCI+B2M) |
N00364 |
| | | | E5 | ⊣ | (MHCI+BCAP31) |
| | |
Cell cycle |
N00347 |
| | (ATM,ATR) | → | TADA3 | → | EP300 | → | TP53 | ⇒ | CDKN1A | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00372 |
E7 | → | ATM |
N00349 |
| | E6 | ⊣ | TADA3 |
N00348 |
| | | | E6 | ⊣ | EP300 |
N00358 |
| | | | | | (E6+UBE3A) | ⊣ | TP53 |
N00362 |
| | | | | | | | E5 | ⊣ | (CDKN1A,CDKN1B) |
N00091 |
| | | | | | | | (SCF+SKP2) | ⊣ | CDKN1B | ⊣ | ((CCNA,CCNE)+CDK2) | → | RB1 | ⌿ | E2F |
N00359 |
| | | | | | | | E7 | ⊣ | (CDKN1A,CDKN1B) |
N00360 |
| | | | | | | | | | E7 | → | (CCNE+CDK2) | → | RB1 | ⌿ | E2F |
N00361 |
| | | | | | | | | | | | E7 | → | (RB1,RBL1,RBL2) | ⌿ | E2F |
N00365 |
| | | | | | | | | | E7 | → | PSMC1 | → | RB1 |
| | |
TNF signaling |
N00145 |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | FADD | → | CASP8 | → | (CASP3,CASP7) |
N00350 |
E6 | ⊣ | TNFRSF1A |
N00351 |
| | | | E6 | ⊣ | FADD |
N00352 |
| | | | | | E6 | ⊣ | CASP8 |
N00098 |
| | (PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00384 |
E6 | ⊣ | BAD |
N00383 |
| | | | (E6+UBE3A) | ⊣ | BAK1 |
| | |
Cytoskeletal regulation |
N00340 |
LLGL | = | SCRIB | = | DLG1 |
N00341 |
| | (E6+UBE3A) | ⊣ | (DLG1+SCRIB) |
N00342 |
| | MAGI | → | PTEN | ⊣ | PIP3 | → | AKT |
N00343 |
(E6+UBE3A) | ⊣ | MAGI1 |
N00344 |
CRB3 | = | MPP5 | = | PATJ |
N00345 |
| | (E6+UBE3A) | ⊣ | PATJ |
| | |
Pyruvate kinase regulation |
N00370 |
PEP | − | PKM | → | Pyruvate |
N00371 |
E7 | ⊣ | PKM |
| | |
Transcription |
N00373 |
(E6+UBE3A) | ⊣ | NFX1 | ⫤ | TERT |
N00376 |
E7 | ⊣ | TBP |
|