KEGG    Network variation - Human papillomavirus (HPV)
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ENTRYnt06166
NameHuman papillomavirus (HPV)
CategoryDisease view; Viral infection
Pathwayhsa05165 Human papillomavirus infection
GenomeT40087 T40088
DiseaseH00030 Cervical cancer
Display drug-target relation   disease type
ERK signaling
N00001      EGFEGFRGRB2SOSRASRAFMEKERKCCND1
N00367    E5V-ATPaseEGFRGRB2SOSRASRAFMEKERK
N00015      PDGFPDGFRGRB2SOSRASRAFMEKERK
N00369      E5PDGFRB
 
PI3K signaling
N00033      EGFEGFRPI3KPIP3AKTBAD
N00366    E5V-ATPaseEGFR
N00039      PDGFPDGFRPI3KPIP3AKTMTORS6K
N00368      E5PDGFRB
N00582      IGF1IGF1RPI3KPIP3AKT(TSC1+TSC2)RHEBMTOREIF4EBP1
N00357              (E6+UBE3A)(TSC1+TSC2)
N00220          PTENPIP3AKT
N00353      E6SLC9A3R1PTEN
N00354        E6PTEN
N00355            PP2AAKT
N00356          E7PP2A
 
NOTCH signaling
N00086      (DLL,JAG)NOTCH(NICD+RBPJ)(HES1,HEY1)
N00380    E6JAG1NOTCH(NICD+RBPJ+MAML)(HES1,HEY1)
N00381    E6MFNGNOTCH(NICD+RBPJ+MAML)(HES1,HEY1)
N00382    E6(NFX1+PSEN1)NOTCH(NICD+RBPJ+MAML)(HES1,HEY1)
 
TLR signaling
N00149    TLR3TICAM1TRAF3(IKBKE+TBK1)IRF3(CREBBP,EP300)IFNB1
N00346          E6IRF3
 
IFN signaling
N00150    (IFNA,IFNB1)(IFNAR1+IFNAR2)(JAK1,TYK2)(STAT1+STAT2+IRF9)(IRF7,EIF2AK2)
N00377      E6TYK2
N00378        E6(STAT1+STAT2+IRF9)
N00379        E7(STAT1+STAT2+IRF9)
 
TNF signaling
N00374    TNFTNFRSF1BIRF1IFNB1
N00375      (E7+HDAC+CHD4)IRF1
 
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00364        E5(MHCI+BCAP31)
 
Cell cycle
N00347      (ATM,ATR)TADA3EP300TP53CDKN1A(CCND+CDK4/6)RB1E2F
N00372    E7ATM
N00349      E6TADA3
N00348        E6EP300
N00358          (E6+UBE3A)TP53
N00362            E5(CDKN1A,CDKN1B)
N00091            (SCF+SKP2)CDKN1B((CCNA,CCNE)+CDK2)RB1E2F
N00359            E7(CDKN1A,CDKN1B)
N00360              E7(CCNE+CDK2)RB1E2F
N00361                E7(RB1,RBL1,RBL2)E2F
N00365              E7PSMC1RB1
 
TNF signaling
N00145    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..FADDCASP8(CASP3,CASP7)
N00350    E6TNFRSF1A
N00351        E6FADD
N00352          E6CASP8
N00098      (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00384    E6BAD
N00383        (E6+UBE3A)BAK1
 
Cytoskeletal regulation
N00340    LLGL=SCRIB=DLG1
N00341      (E6+UBE3A)(DLG1+SCRIB)
N00342      MAGIPTENPIP3AKT
N00343    (E6+UBE3A)MAGI1
N00344    CRB3=MPP5=PATJ
N00345      (E6+UBE3A)PATJ
 
Pyruvate kinase regulation
N00370    PEPPKMPyruvate
N00371    E7PKM
 
Transcription
N00373    (E6+UBE3A)NFX1TERT
N00376    E7TBP