PI3K signaling |
N00220 |
|
PTEN | ⊣ | PIP3 | → | AKT |
N00051 |
|
PTEN* | ⌿ | PIP3 | → | AKT |
N00052 |
|
PTEN* | ⌿ | PIP3 | → | AKT |
Cell cycle |
N00090 |
|
| | (MYC+MAX) | ⊣ | ZBTB17 | ⇒ | CDKN2B | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00088 |
|
| | (MYC*+MAX) | ⊣ | ZBTB17 | ⇒ | CDKN2B | ⊣ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00089 |
|
| | | | | | (MYC*+MAX) | ⇒ | (CCND+CDK4/6) | → | RB1 | ⌿ | E2F |
N00091 |
|
| | | | (SCF+SKP2) | ⊣ | CDKN1B | ⊣ | ((CCNA,CCNE)+CDK2) | → | RB1 | ⌿ | E2F |
N00092 |
|
(MYC*+MAX) | ⇒ | CKS1B | → | (SCF+SKP2) | ⊣ | CDKN1B | ⊣ | (CCNE+CDK2) | → | RB1 | ⌿ | E2F |
N00074 |
|
| | | | | | | | | | RB1* | ⌿ | E2F |
N00075 |
|
| | | | | | | | | | RB1* | ⌿ | E2F |
Apoptosis |
N00098 |
|
(PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
N00100 |
|
| | BCL2* | ⊣ | BAX | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
Transcription |
N00115 |
|
TP53* | ⌿ | (CDKN1A,GADD45,BAX.. |
|