KEGG    Network variation - Calcium signaling
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ENTRYnt06528
NameCalcium signaling
CategoryPathway view; Signal transduction
Pathwayhsa04020 Calcium signaling pathway
DiseaseH00720 Long QT syndrome
H00728 Brugada syndrome
H01019 Catecholaminergic polymorphic ventricular tachycardia
H00293 Arrhythmogenic right ventricular cardiomyopathy
H00606 Early infantile epileptic encephalopathy
H00063 Spinocerebellar ataxia
Display drug-target relation   disease type
N01638            CAV1.1(RYR1+TRDN+JCN+CAS..Ca2+(cyto)
    HOKPP1         CACNA1S*
    CMYP1B           RYR1*
    VMCQA           CASQ1*
N01282          STAC3CAV1.1
    CMYP13       STAC3*
N01639        Ca2+(extracellular..CAV1.2Ca2+(cyto)(RYR2+TRDN+JCN+CAS..Ca2+(cyto)
    LQT8       CACNA1C*
    BRGDA3/NEDHLSS       CACNA1C*
    CPVT1           RYR2*
    ARVD2           RYR2*
    CPVT5           TRDN*
    CPVT2           CASQ2*
 
N01637            Ca2+(extracellular..CAVCa2+(cyto)
    SCA6/FHM1/SHM1           CACNA1A*
    PASNA           CACNA1D*
    DEE69           CACNA1E*
    SCA42           CACNA1G*
    HALD4/EIG6           CACNA1H*
    NEDSIS           CACNA1I*
    DEE42/EA2           CACNA1A*
    NEDNEH           CACNA1B*
    SANDD           CACNA1D*
    CSNB2A/CORDX3/AIED           CACNA1F*
 
N01642            Ca2+(extracellular..LGCCCa2+(cyto)
    DEE46           GRIN2D*
    LKS           GRIN2A*
    DEE27/MRD6           GRIN2B*
    DEE101/MRD8/NDHMSR           GRIN1*
    DFNA41           P2RX2*
 
N01643          Ca2+(er/sr)STIMORAICa2+(cyto)
    TAM1/STRMK         STIM1*
    IMD10         STIM1*
    TAM2           ORAI1*
    IMD9           ORAI1*
 
N01640      GPCRGNAQPLCBIP3ITPRCa2+(cyto)
    SCA44/SCAR13   GRM1*
    DEE58   NTRK2*
    DEE12       PLCB1*
    SCA29           ITPR1*
    SCA15           ITPR1*
N01641      GFRTKPLCGIP3ITPRCa2+(cyto)
    HCC   GF*
    Glioma/NSCLC     RTK*
    DFNB97     MET*
    DFNB39     HGF*
    ANHD           ITPR2*
N01655        Ca2+(cyto)PLCDIP3ITPRCa2+(cyto)
    NDNC3       PLCD1*
 
N01644            PI(3.5)P2MCOLN1Ca2+(cyto)CALM=CNTFEB
    MLIV           MCOLN1*
 
N01645                Ca2+(cyto)ATP2ACa2+(er/sr)
    BROD               ATP2A1*
    DAR/AKV               ATP2A2*
N01646                (PLN,SLN,MLN,ELN,A..ATP2A
    CMH18             PLN*
    CMD1P             PLN*
 
N01429                Ca2+(cyto)ATP2BCa2+(extracellular..
    DFNA82/DFNB12               ATP2B2*
    SCAX1               ATP2B3*
 
N01647                Ca2+(cyto)CALM=CNNFAT
    ACCIID                 PPP3CA*
    DEE91/IECEE1                 PPP3CA*
 
N01648                Ca2+(cyto)CALM=CAMK
    MRD53               CAMK2A*
    MRD54               CAMK2B*
    MRD59               CAMK2G*
    MRT63               CAMK2A*
    AAT7/MMIHS1               MYLK*
    CMH1               MYLK2*
 
N01649                Ca2+(cyto)=CALM=(CAV,RYR)
    LQT14/CPVT4               CALM1*
    LQT15               CALM2*
    LQT16/CPVT6               CALM3*
 
N01741                Ca2+(cyto)PKCTRPC3Ca2+(cyto)
    SCA14               PRKCG*
    SCA41                 TRPC3*
 
N00953    GlutamateGRM1GNAQPLCBIP3ITPRCa2+PKCTRPC3Ca2+
N00984    GlutamateGRM5GNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS=APAF1CASP9(CASP3,CASP7)
N01000    AChmAChRGNAQPLCBIP3ITPRCa2+MCUCa2+(mito)MPTPCYCS

Disease nameDisease category
HOKPP1H00215Periodic paralysisNervous system disease
CMYP1BH01810Congenital myopathyNervous system disease
VMCQAH02320Vacuolar myopathy with CASQ1 aggregatesMusculoskeletal disease
CMYP13H01810Congenital myopathyNervous system disease
LQT8H00720Long QT syndromeCardiovascular disease
BRGDA3/NEDHLSSH00728Brugada syndromeCardiovascular disease
H02397Neurodevelopmental disorder with movement abnormalities or hypotoniaCongenital malformation
CPVT1H01019Catecholaminergic polymorphic ventricular tachycardiaCardiovascular disease
ARVD2H00293Arrhythmogenic right ventricular cardiomyopathyCardiovascular disease
CPVT5H01019Catecholaminergic polymorphic ventricular tachycardiaCardiovascular disease
CPVT2H01019Catecholaminergic polymorphic ventricular tachycardiaCardiovascular disease
SCA6/FHM1/SHM1H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
H00775Hemiplegic migraineNervous system disease
PASNAH01603Primary aldosteronismEndocrine and metabolic disease
DEE69H00606Early infantile epileptic encephalopathyNervous system disease
SCA42H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
HALD4/EIG6H01603Primary aldosteronismEndocrine and metabolic disease
H00808Idiopathic generalized epilepsiesNervous system disease
NEDSISH02397Neurodevelopmental disorder with movement abnormalities or hypotoniaCongenital malformation
DEE42/EA2H00606Early infantile epileptic encephalopathyNervous system disease
H00749Episodic ataxiasNervous system disease
NEDNEHH02397Neurodevelopmental disorder with movement abnormalities or hypotoniaCongenital malformation
SANDDH02636Sinoatrial node dysfunction and deafnessCardiovascular disease
CSNB2A/CORDX3/AIEDH00787Congenital stationary night blindnessNervous system disease
H00481Cone-rod dystrophy and cone dystrophyNervous system disease
H00690Aland Island eye diseaseNervous system disease
DEE46H00606Early infantile epileptic encephalopathyNervous system disease
LKSH01514Landau-Kleffner syndromeNervous system disease
DEE27/MRD6H00606Early infantile epileptic encephalopathyNervous system disease
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
DEE101/MRD8/NDHMSRH00606Early infantile epileptic encephalopathyNervous system disease
H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
H02705Neurodevelopmental disorder with glutamatergic synapse dysfunctionNervous system disease
DFNA41H00604Deafness, autosomal dominantNervous system disease
TAM1/STRMKH02258Tubular aggregate myopathyMusculoskeletal disease
H02259Stormorken syndromeHematologic disease
IMD10H00093Combined immunodeficiencyPrimary immunodeficiency
TAM2H02258Tubular aggregate myopathyMusculoskeletal disease
IMD9H00093Combined immunodeficiencyPrimary immunodeficiency
SCA44/SCAR13H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
H01891Autosomal recessive spinocerebellar ataxiasNeurodegenerative disease
DEE58H00606Early infantile epileptic encephalopathyNervous system disease
DEE12H00606Early infantile epileptic encephalopathyNervous system disease
SCA29H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
SCA15H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
HCCH00048Hepatocellular carcinomaCancer
Glioma/NSCLCH00042GliomaCancer
H00014Non-small cell lung cancerCancer
DFNB97H00605Deafness, autosomal recessiveNervous system disease
DFNB39H00605Deafness, autosomal recessiveNervous system disease
ANHDH02281Isolated anhidrosis with normal sweat glandsSkin disease
NDNC3H01307Nonsyndromic congenital nail disorderSkin disease
MLIVH00144Mucolipidosis IVInherited metabolic disorder, Lysosomal disease
BRODH01129Brody myopathyNervous system disease
DAR/AKVH00715Darier diseaseCongenital malformation
H00755Acrokeratosis verruciformisCongenital malformation
CMH18H00292Hypertrophic cardiomyopathyCardiovascular disease
CMD1PH00294Dilated cardiomyopathyCardiovascular disease
DFNA82/DFNB12H00604Deafness, autosomal dominantNervous system disease
H00605Deafness, autosomal recessiveNervous system disease
SCAX1H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
ACCIIDH02641Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual developmentCongenital malformation
DEE91/IECEE1H00606Early infantile epileptic encephalopathyNervous system disease
H02150Infantile or early childhood epileptic encephalopathyNervous system disease
MRD53H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRD54H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRD59H00773Autosomal dominant intellectual developmental disorderMental and behavioural disorder
MRT63H00768Autosomal recessive intellectual developmental disorderMental and behavioural disorder
AAT7/MMIHS1H00801Familial thoracic aortic aneurysm and dissectionCardiovascular disease
H01869Megacystis microcolon intestinal hypoperistalsis syndromeCongenital malformation
CMH1H00292Hypertrophic cardiomyopathyCardiovascular disease
LQT14/CPVT4H00720Long QT syndromeCardiovascular disease
H01019Catecholaminergic polymorphic ventricular tachycardiaCardiovascular disease
LQT15H00720Long QT syndromeCardiovascular disease
LQT16/CPVT6H00720Long QT syndromeCardiovascular disease
H01019Catecholaminergic polymorphic ventricular tachycardiaCardiovascular disease
SCA14H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease
SCA41H00063Spinocerebellar ataxia (SCA)Neurodegenerative disease