Tetrahydropalmatine; (S)-Tetrahydropalmatine

Palmatine; 5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium

S-Adenosyl-L-methionine:columbamine O-methyltransferase; S-Adenosyl-L-methionine + Columbamine <=> S-Adenosyl-L-homocysteine + Palmatine

S-Adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase; S-Adenosyl-L-methionine + Isocorypalmine <=> S-Adenosyl-L-homocysteine + Tetrahydropalmatine

S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase; S-Adenosyl-L-methionine + Palmatine + 2 NADPH <=> S-Adenosyl-L-homocysteine + Corydaline + 2 NADP+

tetrahydropalmatine:oxygen oxidoreductase; Tetrahydropalmatine + 2 Oxygen + H+ <=> Palmatine + 2 Hydrogen peroxide