Entry |
|
Name |
aromatic 2-oxoacid reductase;
(R)-aromatic lactate dehydrogenase;
(R)-4-hydroxyphenyllactate dehydrogenase;
indolelactate:NAD+ oxidoreductase;
indolelactate dehydrogenase;
fldH (gene name);
(indol-3-yl)lactate:NAD+ oxidoreductase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
aromatic 2-oxoacid:NAD+ oxidoreductase
|
Reaction(IUBMB) |
(1) (R)-3-(phenyl)lactate + NAD+ = 3-phenylpyruvate + NADH + H+ [RN: R01370];
(2) (R)-3-(4-hydroxyphenyl)lactate + NAD+ = 3-(4-hydroxyphenyl)pyruvate + NADH + H+ [RN: R03337];
(3) (R)-(indol-3-yl)lactate + NAD+ = (indol-3-yl)pyruvate + NADH + H+ [RN: R12256]
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Reaction(KEGG) |
|
Substrate |
(R)-3-(phenyl)lactate [CPD: C05607];
NAD+ [CPD: C00003];
(R)-3-(4-hydroxyphenyl)lactate [CPD: C03964];
(R)-(indol-3-yl)lactate [CPD: C22006]
|
Product |
3-phenylpyruvate;
NADH [CPD: C00004];
H+ [CPD: C00080];
3-(4-hydroxyphenyl)pyruvate [CPD: C01179];
(indol-3-yl)pyruvate [CPD: C00331]
|
Comment |
The enzymes from anaerobic bacteria such as Clostridium sporogenes participate in the fermentation pathways of L-phenylalanine, L-tyrosine and L-tryptophan. The enzyme from the yeast Candida maltosa has similar activity, but, unlike the bacterial enzyme, requires Mn2+ and can also use NADPH with lower activity.
|
History |
EC 1.1.1.110 created 1972 (EC 1.1.1.222 created 2000, incorporated 2018), modified 2018
|
Pathway |
ec00960 | Tropane, piperidine and pyridine alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K23109 | aromatic 2-oxoacid reductase |
|
Genes |
» show all
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Reference |
|
Authors |
Jean M, DeMoss RD. |
Title |
Indolelactate dehydrogenase from Clostridium sporogenes. |
Journal |
|
Reference |
|
Authors |
Giesel H, Simon H |
Title |
On the occurrence of enoate reductase and 2-oxo-carboxylate reductase in clostridia and some observations on the amino acid fermentation by Peptostreptococcus anaerobius. |
Journal |
|
Reference |
3 |
Authors |
Bode, R., Lippoldt, A. and Birnbaum, D. |
Title |
Purification and properties of D-aromatic lactate dehydrogenase an enzyme involved in the catabolism of the aromatic amino acids of Candida maltosa. |
Journal |
Biochem Physiol Pflanzen 181:189-198 (1986) |
Reference |
|
Authors |
Dickert S, Pierik AJ, Linder D, Buckel W |
Title |
The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes. |
Journal |
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Sequence |
|
Reference |
|
Authors |
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL |
Title |
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.110 |
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LinkDB |
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