| Entry |
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| Name |
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| Class |
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxygenases
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| Sysname |
L-tyrosine:hydrogen-peroxide oxidoreductase (L-dopa-forming)
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| Reaction(IUBMB) |
L-tyrosine + H2O2 = L-dopa + H2O [RN: R12611]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme from the bacterium Streptomyces lincolnensis participates in the biosynthesis of the antibiotic lincomycin A, while that from Streptomyces refuineus is involved in anthramycin biosynthesis. The enzyme, which contains a heme b cofactor, is rapidly inactivated in the presence of hydrogen peroxide, but the presence of L-tyrosine protects it. cf. EC 1.11.2.5, 3-methyl-L-tyrosine peroxygenase.
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| History |
EC 1.11.2.6 created 2020
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K24287 | L-tyrosine peroxygenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W |
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| Title |
The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A. |
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| Journal |
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| Reference |
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| Authors |
Connor KL, Colabroy KL, Gerratana B |
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| Title |
A heme peroxidase with a functional role as an L-tyrosine hydroxylase in the biosynthesis of anthramycin. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.11.2.6 |
| ExPASy - ENZYME nomenclature database: | 1.11.2.6 |
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| LinkDB |
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