KEGG   ENZYME: 1.13.11.30
Entry
EC 1.13.11.30               Enzyme                                 

Name
stizolobinate synthase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
3,4-dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
Reaction(IUBMB)
L-dopa + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [RN:R02076]
Reaction(KEGG)
R02076;
(other) R04600 R04601
Substrate
L-dopa [CPD:C00355];
O2 [CPD:C00007]
Product
5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde [CPD:C04797]
Comment
The intermediate product undergoes ring closure and oxidation, with NAD(P)+ as acceptor, to stizolobinic acid. The enzyme requires Zn2+.
History
EC 1.13.11.30 created 1978
Pathway
ec00350  Tyrosine metabolism
Reference
1  [PMID:9285]
  Authors
Saito K, Komamine A.
  Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants. An enzyme system(s) catalyzing the conversion of dihydroxyphenylalanine into stizolobinic acid and stizolobic acid from etiolated seedlings of Stizolobium hassjoo.
  Journal
Eur J Biochem 68:237-43 (1976)
DOI:10.1111/j.1432-1033.1976.tb10783.x
Reference
2  [PMID:624278]
  Authors
Saito K, Komamine A.
  Title
Biosynthesis of stizolobinic acid and stizolobic acid in higher plants.
  Journal
Eur J Biochem 82:385-92 (1978)
DOI:10.1111/j.1432-1033.1978.tb12033.x
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.30
IUBMB Enzyme Nomenclature: 1.13.11.30
ExPASy - ENZYME nomenclature database: 1.13.11.30
BRENDA, the Enzyme Database: 1.13.11.30
CAS: 65979-38-6
LinkDB

KEGG   REACTION: R02076
Entry
R02076                      Reaction                               

Name
3,4-Dihydroxy-L-phenylalanine:oxygen 2,3-oxidoreductase (recyclizing)
Definition
3,4-Dihydroxy-L-phenylalanine + Oxygen <=> 5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
Equation
Comment
subsequently R04600 or R04601
Reaction class
RC00643  C00355_C04797
Enzyme
Pathway
rn00350  Tyrosine metabolism
Other DBs
RHEA: 18468
LinkDB

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