| Entry |
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| Name |
4-hydroxyphenylacetate 1-monooxygenase;
4-hydroxyphenylacetate 1-hydroxylase;
4-hydroxyphenylacetic 1-hydroxylase;
4-HPA 1-hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)
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| Reaction(IUBMB) |
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 = homogentisate + NAD(P)+ + H2O [RN: R02514 R02516]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). Also acts on 4-hydroxyhydratropate (forming 2-methylhomogentisate) and on 4-hydroxyphenoxyacetate (forming hydroquinone and glycolate).
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| History |
EC 1.14.13.18 created 1976
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Reference |
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| Authors |
Hareland WA, Crawford RL, Chapman PJ, Dagley S. |
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| Title |
Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans. |
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| Journal |
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| Other DBs |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.14.13.18 |
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| LinkDB |
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